About: In vivo gene regulation using tetracycline-regulatable systems

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About: In vivo gene regulation using tetracycline-regulatable systems Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In vivo gene regulation using tetracycline-regulatable systems
Creator	Belbellaa, Brahim Le Guiner, Caroline Moullier, Philippe Rolling, Fabienne Stieger, Knut
topic	covid:56a9bd299b9219f098f7b1f2cf1d95f7b65aa743#this
Source	Elsevier; Medline; PMC
abstract	Abstract Numerous preclinical studies have demonstrated the efficacy of viral gene delivery vectors, and recent clinical trials have shown promising results. However, the tight control of transgene expression is likely to be required for therapeutic applications and in some instances, for safety reasons. For this purpose, several ligand-dependent transcription regulatory systems have been developed. Among these, the tetracycline-regulatable system is by far the most frequently used and the most advanced towards gene therapy trials. This review will focus on this system and will describe the most recent progress in the regulation of transgene expression in various organs, including the muscle, the retina and the brain. Since the development of an immune response to the transactivator was observed following gene transfer in the muscle of nonhuman primate, focus will be therefore, given on the immune response to transgene products of the tetracycline inducible promoter.
has issue date	2009-07-02(xsd:dateTime)
bibo:doi	10.1016/j.addr.2008.12.016
bibo:pmid	19394373
has license	els-covid
sha1sum (hex)	56a9bd299b9219f098f7b1f2cf1d95f7b65aa743
schema:url	https://doi.org/10.1016/j.addr.2008.12.016
resource representing a document's title	In vivo gene regulation using tetracycline-regulatable systems
has PubMed Central identifier	PMC7103297
has PubMed identifier	19394373
schema:publication	Advanced Drug Delivery Reviews
resource representing a document's body	covid:56a9bd299b9219f098f7b1f2cf1d95f7b65aa743#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/56a9bd299b9219f098f7b1f2cf1d95f7b65aa743
is schema:about of	named entity 'Since' named entity 'frequently' named entity 'instances' named entity 'transgene' named entity 'vectors' named entity 'FOCUS' named entity 'PURPOSE' named entity 'APPLICATIONS' named entity 'GENE TRANSFER' named entity 'EFFICACY' named entity 'RESULTS' named entity 'SYSTEM' named entity 'OBSERVED' named entity 'LIKELY' named entity 'LIGAND' named entity 'THERAPEUTIC' named entity 'NUMEROUS' named entity 'IMMUNE RESPONSE' named entity 'DEPENDENT' named entity 'TRANSGENE' named entity 'TIGHT' named entity 'NONHUMAN PRIMATE' named entity 'INDUCIBLE PROMOTER' named entity 'FOLLOWING' named entity 'GIVEN' named entity 'IN VIVO' named entity 'GENE REGULATION' named entity 'USING' named entity 'RESPONSE TO' named entity 'ORGANS' named entity 'RECENT' named entity 'SYSTEMS' named entity 'TETRACYCLINE' named entity 'CLINICAL TRIALS' named entity 'TRANSGENE EXPRESSION' named entity 'SAFETY' named entity 'VIRAL GENE' named entity 'INCLUDING' named entity 'VECTORS' named entity 'RETINA' named entity 'REGULATION' named entity 'GENE THERAPY' named entity 'VARIOUS' named entity 'REGULATORY SYSTEMS' named entity 'DEVELOPMENT' named entity 'DESCRIBE' named entity 'REVIEW' named entity 'MUSCLE' named entity 'REQUIRED' named entity 'CONTROL' named entity 'HAVE' named entity 'PROGRESS' named entity 'THE BRAIN' named entity 'ADVANCED' named entity 'DEMONSTRATED' named entity 'REASONS' named entity 'THESE' named entity 'FREQUENTLY' named entity 'GENE DELIVERY' named entity 'PRECLINICAL STUDIES' named entity 'PRODUCTS' named entity 'MOST RECENT' named entity 'TRANSACTIVATOR' named entity 'TRANSCRIPTION' named entity 'TETRACYCLINE' named entity 'USED' named entity 'FAR' named entity 'focus' named entity 'immune response' named entity 'preclinical studies' named entity 'system' named entity 'brain' named entity 'expression' named entity 'tetracycline' named entity 'developed'

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