About: Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease

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About: Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease
Creator	Hao, Ke Zhu, Jun Kasarskis, Andrew Ungaro, Ryan Wang, Wenhui Corley, Michael Dubinsky, Marla Jha, Divya Mehandru, Saurabh Ndhlovu, Lishomwa Schadt, Eric Suprun, Maria Argmann, Carmen Brodmerkel, Carrie Cerf-Benssusan, Nadine Cho, Judy Colombel, Jean Cording, Sascha Curran, Mark Di'narzo, Antonio Friedman, Joshua Harpaz, Noam Houten, Sander Huang, Ruiqi Irizar, Haritz Ko, Huaibin Kosoy, Roman Levescot, Anais Livanos, Alexandra Martinez, Gustavo Perrigoue, Jacqueline Sands, Bruce Stojmirovic, Aleksandar Suárez-Fariñas, Mayte Tokuyama, Minami Wei, Gabrielle
Source	BioRxiv
abstract	Immune dysregulation and cytokine release syndrome have emerged as pathological hallmarks of severe Coronavirus Disease 2019 (COVID-19), leading to the evaluation of cytokine antagonists as therapeutic agents. A number of immune-directed therapies being considered for COVID-19 patients are already in clinical use in chronic inflammatory conditions like inflammatory bowel disease (IBD). These considerations led us to systematically examine the intersections between COVID-19 and the GI tract during health and intestinal inflammation. We have observed that IBD medications, both biologic and non-biologic, do not significantly impact ACE2 and TMPRSS2 expression in the uninflamed intestines. Additionally, by comparing SARS CoV2-induced epithelial gene signatures with IBD-associated genes, we have identified a shared molecular subnetwork between COVID-19 and IBD. These data generate a novel appreciation of the confluence of COVID-19- and IBD-associated inflammation and provide mechanistic insights supporting further investigation of specific IBD drugs in the treatment of COVID-19.
has issue date	2020-05-23(xsd:dateTime)
bibo:doi	10.1101/2020.05.21.109124
has license	biorxiv
sha1sum (hex)	567deeda3fa45bdf7b8da85fb58cacf87feb624a
schema:url	https://doi.org/10.1101/2020.05.21.109124
resource representing a document's title	Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease
schema:publication	bioRxiv
resource representing a document's body	covid:567deeda3fa45bdf7b8da85fb58cacf87feb624a#body_text
is schema:about of	named entity 'ACE2' named entity 'inflammation' named entity 'ACE2' named entity 'ACE2' named entity 'protein' named entity 'epithelial' named entity 'IBD' named entity 'cytokine release syndrome' named entity 'therapeutic agents' named entity 'inflammatory bowel disease' named entity 'ACE2' named entity 'TMPRSS2' named entity 'pathogenesis' named entity 'gene' named entity 'TNF-α' named entity 'IBD' named entity 'IBD' named entity 'pathogenesis' named entity 'Colon' named entity 'tight junction' named entity 'inflammation' named entity 'ACE2' named entity 'COVID-19 infection' named entity 'subnetwork' named entity 'crypt epithelium' named entity 'thiopurine' named entity 'sub-networks' named entity 'SARS-CoV-2' named entity 'F11R' named entity 'TMPRSS2' named entity 'ACE2' named entity 'ACE2' named entity 'IBD' named entity 'TMPRSS2' named entity 'ileum' named entity 'inflamed colon' named entity 'biopsies' named entity 'ACE2' named entity 'infection' named entity 'single cell' named entity 'ACE2' named entity 'Venn diagrams' named entity 'lung' named entity 'gene expression profiles' named entity 'p<0.05' named entity 'gene' named entity 'brush border' named entity 'TMPRSS2' named entity 'IBD'

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