About: MELD–Na Is More Strongly Associated with Risk of Infection and Outcomes Than Other Characteristics of Patients with Cirrhosis

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About: MELD–Na Is More Strongly Associated with Risk of Infection and Outcomes Than Other Characteristics of Patients with Cirrhosis Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	MELD–Na Is More Strongly Associated with Risk of Infection and Outcomes Than Other Characteristics of Patients with Cirrhosis
Creator	Chalasani, Naga Akinyeye, Samuel Attar, M Balakrishnan, Maya Bashar, · Fricker, Zachary Ghabril, Marwan Long, Michelle Mukthinuthalapati, Kedar Pavan, · Stroger Hospital, John
Source	PMC
abstract	BACKGROUND AND AIMS: The nature and outcomes of infection among patients with cirrhosis in safety-net hospitals are not well described. We aimed to characterize the rate of and risk factors for infection, both present on admission and nosocomial, in this unique population. We hypothesized that infections would be associated with adverse outcomes such as short-term mortality. METHODS: We used descriptive statistics to characterize infections within a retrospective cohort characterized previously. We used multivariable logistic regression models to assess potential risk factors for infection and associations with key outcomes such as short-term mortality and length of stay. RESULTS: The study cohort of 1112 patients included 33% women with a mean age of 56 ± 10 years. Infections were common (20%), with respiratory and urinary tract infections the most frequent. We did not observe a difference in the incidence of infection on admission based on patient demographic factors such as race/ethnicity or estimated household income. Infections on admission were associated with greater short-term mortality (12% vs 4% in-hospital and 14% vs 7% 30-day), longer length of stay (6 vs 3 days), intensive care unit admission (28% vs 18%), and acute-on-chronic liver failure (10% vs 2%) (p < 0.01 for all). Nosocomial infections were relatively uncommon (4%), but more frequent among patients admitted to the intensive care unit. Antibiotic resistance was common (38%), but not associated with negative outcomes. CONCLUSION: We did not identify demographic risk factors for infection, but did confirm its morbid effect among patients with cirrhosis in safety-net hospitals. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10620-020-06164-y) contains supplementary material, which is available to authorized users.
has issue date	2020-02-25(xsd:dateTime)
bibo:doi	10.1007/s10620-020-06164-y
bibo:pmid	32100160
has license	no-cc
sha1sum (hex)	538a12a2db9dbfad75c9804b320f5323bc4eb8f7
schema:url	https://doi.org/10.1007/s10620-020-06164-y
resource representing a document's title	MELD–Na Is More Strongly Associated with Risk of Infection and Outcomes Than Other Characteristics of Patients with Cirrhosis
has PubMed Central identifier	PMC7222109
has PubMed identifier	32100160
schema:publication	Dig Dis Sci
resource representing a document's body	covid:538a12a2db9dbfad75c9804b320f5323bc4eb8f7#body_text
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