About: Influence of positive end-expiratory pressure (PEEP) on histopathological and bacteriological aspects of pneumonia during low tidal volume mechanical ventilation

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About: Influence of positive end-expiratory pressure (PEEP) on histopathological and bacteriological aspects of pneumonia during low tidal volume mechanical ventilation Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Influence of positive end-expiratory pressure (PEEP) on histopathological and bacteriological aspects of pneumonia during low tidal volume mechanical ventilation
Creator	Pugin, J Charles, P Pugin, Jerome Chavanet, Pascal Chavanet, · Croisier, Etienne Croisier, · Emmanuel, Pierre Etienne, · Laurent, Charles Lequeu, Catherine Lequeu, · Manuel, Martin Martin, L Piroth, Lionel Piroth, · Portier, Henri Portier, ·
Source	PMC
abstract	OBJECTIVE: Ventilatory strategies combining low tidal volume (V(T)) with positive end-expiratory pressure (PEEP) are considered to be lung protective. The influence of the PEEP level was investigated on bacteriology and histology in a model of ventilator-associated pneumonia. SUBJECTS: Nineteen New Zealand rabbits. INTERVENTIONS: The animals were mechanically ventilated with a positive inspiratory pressure of 15 cmH(2)O and received either a zero end-expiratory pressure (ZEEP, n=6), a 5 cmH(2)O PEEP (n=5) or a 10 cmH(2)O PEEP (n=4). An inoculum of Enterobacter aerogenes was then instilled intrabronchially. The non-ventilated pneumonia group (n=4) was composed of spontaneously breathing animals which received the same inoculum. Pneumonia was assessed 24 h later. MAIN RESULTS: The lung bacterial burden was higher in mechanically ventilated animals compared with spontaneously breathing animals. All animals from the latter group had negative spleen cultures. The spleen bacterial concentration was found to be lower in the 5 cmH(2)O PEEP group when compared to the ZEEP and 10 cmH(2)O PEEP groups (3.1±1.5 vs 4.9±1.1 and 5.0±1.3 log(10) cfu/g, respectively; p<0.05). Lung weight and histological score values were lower in the spontaneously breathing animals as well as in the 5 cmH(2)O PEEP group compared with the ZEEP and 10 cmH(2)O groups. CONCLUSIONS: Mechanical ventilation substantially increased the lung bacterial burden and worsened the histological aspects of pneumonia in this rabbit model. Variations in terms of lung injury and systemic spreading of infection were noted with respect to the ventilatory strategy.
has issue date	2004-11-04(xsd:dateTime)
bibo:doi	10.1007/s00134-004-2442-y
bibo:pmid	15536527
has license	no-cc
sha1sum (hex)	5355e62fecbd6e0163f67396f9273dd2398accf9
schema:url	https://doi.org/10.1007/s00134-004-2442-y
resource representing a document's title	Influence of positive end-expiratory pressure (PEEP) on histopathological and bacteriological aspects of pneumonia during low tidal volume mechanical ventilation
has PubMed Central identifier	PMC7095170
has PubMed identifier	15536527
schema:publication	Intensive Care Med
resource representing a document's body	covid:5355e62fecbd6e0163f67396f9273dd2398accf9#body_text
is schema:about of	named entity 'Influence' named entity 'STRATEGIES' named entity 'tidal volume' named entity 'lung' named entity 'PEEP' named entity 'PEEP' named entity 'pneumonia' named entity 'emphysema' named entity 'PEEP' named entity 'infection' named entity 'inflammatory cells' named entity 'central venous catheter' named entity 'pneumonia' named entity 'anesthesia' named entity 'immunosuppressed' named entity 'alveolar' named entity 'lung injury' named entity 'inoculum' named entity 'statistical significance' named entity 'ZEEP' named entity 'pneumonia' named entity 'PEEP' named entity 'ventilator-induced lung injury' named entity 'acute lung injury' named entity 'pneumonia' named entity 'pneumonic' named entity 'pneumonia' named entity 'lung injury' named entity 'inoculation' named entity 'proinflammatory' named entity 'macroscopic' named entity 'PEEP' named entity 'alveoli' named entity 'spleen' named entity 'ZEEP' named entity 'pneumonia' named entity 'supine' named entity 'PEEP' named entity 'pneumonia' named entity 'tidal volume' named entity 'Enterobacter aerogenes' named entity 'lung injury' named entity 'histological' named entity 'Positive pressure ventilation' named entity 'lung edema' named entity 'PEEP' named entity 'histological' named entity 'PEEP' named entity 'clinical practice' named entity 'inoculum' named entity 'PEEP' named entity 'pneumonia' named entity 'antibody' named entity 'pneumonia' named entity 'Lung injury' named entity 'PEEP' named entity 'spleen' named entity 'lungs' named entity 'bronchi' named entity 'one-way analysis of variance' named entity 'pneumonia' named entity 'endotracheal tube' named entity 'hemodynamic' named entity 'lung inflammation'

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