About: PATHOLOGICAL MANIFESTATIONS OF FELINE IMMUNODEFICIENCY VIRUS (FIV) INFECTION IN WILD AFRICAN LIONS

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	PATHOLOGICAL MANIFESTATIONS OF FELINE IMMUNODEFICIENCY VIRUS (FIV) INFECTION IN WILD AFRICAN LIONS
Creator	Pecon-Slattery, Jill Roelke, Melody Winterbach, Christiaan Winterbach, Hanlie Hemson, Graham Klein, Lin Smith, Dahlem Brown, Meredith O'brien, Stephen Roca, Alfred Troyer, Jennifer Alexander, Katherine Johnson, Randall Krishnasamu, Karthiuani Martinelli, Paulo
topic	covid:53418502dd5cdd7ae9e551ecd15398af5613b5b6#this
Source	Elsevier; Medline; PMC
abstract	Feline immunodeficiency virus (FIV) causes AIDS in the domestic cat (Felis catus) but has not been explicitly associated with AIDS pathology in any of the eight free-ranging species of Felidae that are endemic with circulating FIV strains. African lion (Panthera leo) populations are infected with lion-specific FIV strains (FIVple), yet there remains uncertainty about the degree to which FIV infection impacts their health. Reported CD4+ T-lymphocyte depletion in FIVple infected lions and anecdotal reports of lion morbidity associated with FIV sero-prevalence emphasize the concern as to whether FIVple is innocuous or pathogenic. Here we monitored clinical, biochemical, histological and serological parameters among FIVple-positive (N=47) as compared to FIVple negative (N=17) lions anesthetized and sampled on multiple occasions between 1999 and 2006 in Botswana. Relative to uninfected lions, FIVple infected lions displayed a significant elevation in the prevalence of AIDS defining conditions: lymphandenopathy, gingivitis, tongue papillomas, dehydration, and poor coat condition, as well as displaying abnormal red blood cell parameters and elevated liver enzymes and serum proteins. Spleen and lymph node laparoscopic biopsies from free-ranging FIVple infected lions (N=8) revealed evidence of lymphoid depletion, the hallmark pathology documented in immunodefieciency virus infections of humans (HIV-1), macaques, and domestic cats. We conclude that over time FIVple infections in free-ranging lions can lead to adverse clinical, immunological, and pathological outcomes in some individuals that parallel sequelae caused by lentivirus infection in humans (HIV), Asian macaques (SIV) and domestic cats (FIVfca).
has issue date	2009-07-01(xsd:dateTime)
bibo:doi	10.1016/j.virol.2009.04.011
bibo:pmid	19464039
has license	green-oa
sha1sum (hex)	53418502dd5cdd7ae9e551ecd15398af5613b5b6
schema:url	https://doi.org/10.1016/j.virol.2009.04.011
resource representing a document's title	PATHOLOGICAL MANIFESTATIONS OF FELINE IMMUNODEFICIENCY VIRUS (FIV) INFECTION IN WILD AFRICAN LIONS
has PubMed Central identifier	PMC2771374
has PubMed identifier	19464039
schema:publication	Virology
resource representing a document's body	covid:53418502dd5cdd7ae9e551ecd15398af5613b5b6#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/53418502dd5cdd7ae9e551ecd15398af5613b5b6
is schema:about of	named entity 'AFRICAN' named entity 'INFECTION' named entity 'FELINE IMMUNODEFICIENCY VIRUS' named entity 'conditions' named entity 'FIV' named entity 'defining' named entity 'infected' named entity 'documented' named entity 'dehydration' named entity 'Relative' named entity 'histological' named entity 'Public Access' named entity 'NIH' named entity 'WILD' named entity 'DOMESTIC' named entity 'DOMESTIC CAT' named entity 'RELATIVE TO' named entity 'ELEVATION' named entity 'MORBIDITY' named entity 'PATHOLOGY' named entity 'COMPARED' named entity 'T-LYMPHOCYTE' named entity 'CD4' named entity 'CONDITIONS' named entity 'BUT' named entity '3D8' named entity 'CONDITION' named entity 'SPECIES' named entity 'MACAQUES' named entity 'SPLEEN' named entity 'REVEALED' covid:arg/53418502dd5cdd7ae9e551ecd15398af5613b5b6 named entity 'REPORTED' named entity 'AFRICAN' named entity 'FIV' named entity 'PARAMETERS' named entity 'AIDS' named entity 'SEROLOGICAL' named entity 'FELIDAE' named entity 'ABOUT' named entity 'THEIR' named entity 'COAT' named entity 'DEHYDRATION' named entity 'EVIDENCE OF' named entity 'BIOCHEMICAL' named entity 'CATS' named entity 'CLINICAL' named entity 'CONCERN' named entity 'LYMPHOCYTE DEPLETION' named entity 'BOTSWANA' named entity 'PATHOGENIC' named entity 'GINGIVITIS' named entity 'SERO' named entity 'FELINE IMMUNODEFICIENCY VIRUS' named entity 'MONITORED' named entity 'HEALTH' named entity 'UNINFECTED' named entity 'ABNORMAL RED BLOOD CELL' named entity 'UNCERTAINTY' named entity 'BIOPSIES' named entity 'ASSOCIATED WITH' named entity 'NEGATIVE' named entity 'PAPILLOMAS' named entity 'POOR' named entity 'LION'

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