About: Clarithromycin Suppresses Human Respiratory Syncytial Virus Infection-Induced Streptococcus pneumoniae Adhesion and Cytokine Production in a Pulmonary Epithelial Cell Line

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About: Clarithromycin Suppresses Human Respiratory Syncytial Virus Infection-Induced Streptococcus pneumoniae Adhesion and Cytokine Production in a Pulmonary Epithelial Cell Line Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clarithromycin Suppresses Human Respiratory Syncytial Virus Infection-Induced Streptococcus pneumoniae Adhesion and Cytokine Production in a Pulmonary Epithelial Cell Line
Creator	Okabayashi, Tamaki Fujii, Nobuhiro Himi, Tetsuo Hirakawa, Satoshi Tsutsumi, Hiroyuki Yokota, Shin-Ichi
Source	PMC
abstract	Human respiratory syncytial virus (RSV) sometimes causes acute and severe lower respiratory tract illness in infants and young children. RSV strongly upregulates proinflammatory cytokines and the platelet-activating factor (PAF) receptor, which is a receptor for Streptococcus pneumoniae, in the pulmonary epithelial cell line A549. Clarithromycin (CAM), which is an antimicrobial agent and is also known as an immunomodulator, significantly suppressed RSV-induced production of interleukin-6, interleukin-8, and regulated on activation, normal T-cell expressed and secreted (RANTES). CAM also suppressed RSV-induced PAF receptor expression and adhesion of fluorescein-labeled S. pneumoniae cells to A549 cells. The RSV-induced S. pneumoniae adhesion was thought to be mediated by the host cell's PAF receptor. CAM, which exhibits antimicrobial and immunomodulatory activities, was found in this study to suppress the RSV-induced adhesion of respiratory disease-causing bacteria, S. pneumoniae, to host cells. Thus, CAM might suppress immunological disorders and prevent secondary bacterial infections during RSV infection.
has issue date	2012-06-12(xsd:dateTime)
bibo:doi	10.1155/2012/528568
bibo:pmid	22761540
has license	cc-by
sha1sum (hex)	5326626cf66eb61f7f001c6557c23058b57fb2e2
schema:url	https://doi.org/10.1155/2012/528568
resource representing a document's title	Clarithromycin Suppresses Human Respiratory Syncytial Virus Infection-Induced Streptococcus pneumoniae Adhesion and Cytokine Production in a Pulmonary Epithelial Cell Line
has PubMed Central identifier	PMC3384978
has PubMed identifier	22761540
schema:publication	Mediators Inflamm
resource representing a document's body	covid:5326626cf66eb61f7f001c6557c23058b57fb2e2#body_text
is schema:about of	named entity 'mediated' named entity 'immunomodulator' named entity 'host' named entity 'cells' named entity 'bacterial infections' named entity 'cells' named entity 'expression' named entity 'acute' named entity 'INDUCED' named entity 'BACTERIA' named entity 'PRODUCTION' named entity 'EXPRESSED' named entity 'HOST CELL' named entity 'IMMUNOLOGICAL' named entity 'STUDY' named entity 'INFANTS' named entity 'IS A' named entity 'CAM' named entity 'HOST CELLS' named entity 'CELLS' named entity 'A549 CELLS' named entity 'HUMAN RESPIRATORY SYNCYTIAL VIRUS' named entity 'PAF RECEPTOR' named entity 'EPITHELIAL CELL LINE' named entity '27S' named entity 'ANTIMICROBIAL AGENT' named entity 'PROINFLAMMATORY CYTOKINES' named entity 'THOUGHT' named entity 'CAUSES' named entity 'EXHIBITS' named entity 'PULMONARY EPITHELIAL CELL' named entity 'FLUORESCEIN' named entity 'YOUNG CHILDREN' named entity 'IMMUNOMODULATOR' named entity 'RESPIRATORY DISEASE' named entity 'RSV' named entity 'SUPPRESSED' named entity 'ACUTE' named entity 'MEDIATED' named entity 'CAUSING' named entity 'CYTOKINE PRODUCTION' named entity 'EPITHELIAL CELL LINE' named entity 'ILLNESS' named entity 'NORMAL' named entity 'LOWER RESPIRATORY TRACT' named entity 'LABELED' named entity 'STREPTOCOCCUS PNEUMONIAE' named entity 'ACTIVATION' named entity 'RECEPTOR' named entity 'SECONDARY' named entity 'IMMUNOMODULATORY' named entity 'ADHESION' named entity 'KNOWN' named entity 'ADHESION' named entity 'T-CELL' named entity 'BACTERIAL INFECTIONS' named entity 'SUPPRESSES' named entity 'PULMONARY EPITHELIAL CELL' named entity 'HUMAN RESPIRATORY SYNCYTIAL VIRUS INFECTION' named entity 'SEVERE' named entity 'PREVENT' named entity 'CLARITHROMYCIN' named entity 'ACTIVITIES' named entity 'STREPTOCOCCUS PNEUMONIAE' named entity 'ANTIMICROBIAL' named entity 'RSV INFECTION' named entity 'REGULATED' named entity 'CLARITHROMYCIN' named entity 'INDUCED' named entity 'INTERLEUKIN-8' named entity 'DISORDERS' named entity 'A549' named entity 'SUPPRESS' named entity 'SECRETED' named entity 'FOUND' named entity 'RECEPTOR EXPRESSION'

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