About: Central nervous system recruitment of effector memory CD8(+) T lymphocytes during neuroinflammation is dependent on α4 integrin

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About: Central nervous system recruitment of effector memory CD8(+) T lymphocytes during neuroinflammation is dependent on α4 integrin Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Central nervous system recruitment of effector memory CD8(+) T lymphocytes during neuroinflammation is dependent on α4 integrin
Creator	Bernard, Monique Arbour, Nathalie Prat, Alexandre Talbot, Pierre Duquette, Pierre Ifergan, Igal Kebir, Hania Marceau, Gabriel Alvarez, Jorge Bourbonniè, Lyne Poirier, José
topic	covid:52960cbce549d2e88be69df08c2b945cb7154adf#this
Source	Medline; PMC
abstract	Clonally expanded CD8(+) T lymphocytes are present in multiple sclerosis lesions, as well as in the cerebrospinal fluid of patients with multiple sclerosis. In experimental autoimmune encephalomyelitis, CD8(+) T lymphocytes are found in spinal cord and brainstem lesions. However, the exact phenotype of central nervous system-infiltrating CD8(+) T lymphocytes and the mechanism by which these cells cross the blood–brain barrier remain largely unknown. Using cerebrospinal fluid from patients with multiple sclerosis, spinal cord from experimental autoimmune encephalomyelitis and coronavirus-induced encephalitis, we demonstrate that central nervous system-infiltrating CD8(+) T lymphocytes are mostly of the effector memory phenotype (CD62L(−) CCR7(−) granzymeB(hi)). We further show that purified human effector memory CD8(+) T lymphocytes transmigrate more readily across blood-brain barrier-endothelial cells than non-effector memory CD8(+) T lymphocytes, and that blood-brain barrier endothelium promotes the selective recruitment of effector memory CD8(+) T lymphocytes. Furthermore, we provide evidence for the recruitment of interferon-γ- and interleukin-17-secreting CD8(+) T lymphocytes by human and mouse blood-brain barrier endothelium. Finally, we show that in vitro migration of CD8(+) T lymphocytes across blood-brain barrier-endothelial cells is dependent on α4 integrin, but independent of intercellular adhesion molecule-1/leucocyte function-associated antigen-1, activated leucocyte cell adhesion molecule/CD6 and the chemokine monocyte chemotactic protein-1/CCL2. We also demonstrate that in vivo neutralization of very late antigen-4 restricts central nervous system infiltration of CD8(+) T lymphocytes in active immunization and adoptive transfer experimental autoimmune encephalomyelitis, and in coronavirus-induced encephalitis. Our study thus demonstrates an active role of the blood-brain barrier in the recruitment of effector memory CD8(+) T lymphocytes to the CNS compartment and defines α4 integrin as a major contributor of CD8(+) T lymphocyte entry into the brain.
has issue date	2011-11-04(xsd:dateTime)
bibo:doi	10.1093/brain/awr268
bibo:pmid	22058139
has license	no-cc
sha1sum (hex)	52960cbce549d2e88be69df08c2b945cb7154adf
schema:url	https://doi.org/10.1093/brain/awr268
resource representing a document's title	Central nervous system recruitment of effector memory CD8(+) T lymphocytes during neuroinflammation is dependent on α4 integrin
has PubMed Central identifier	PMC7110084
has PubMed identifier	22058139
schema:publication	Brain
resource representing a document's body	covid:52960cbce549d2e88be69df08c2b945cb7154adf#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/52960cbce549d2e88be69df08c2b945cb7154adf
is schema:about of	named entity 'DEPENDENT' named entity 'EFFECTOR' named entity 'MEMORY' named entity 'INTEGRIN' named entity 'CELL ADHESION MOLECULE' named entity 'MCP' named entity 'BUT' named entity 'LFA' named entity 'INTERCELLULAR ADHESION MOLECULE-1' named entity 'USING' named entity 'INFILTRATING' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'ENTRY' named entity 'MONOCYTE CHEMOTACTIC PROTEIN-1' named entity 'INTERCELLULAR ADHESION MOLECULE' named entity 'BBB' named entity 'CONTRIBUTOR' named entity 'EAE' named entity 'RECRUITMENT' named entity 'ACTIVE IMMUNIZATION' named entity '134' named entity 'BRAINSTEM' named entity 'ANTIGEN' named entity 'MHC' named entity 'SPINAL CORD' named entity 'ADOPTIVE TRANSFER' named entity 'LARGELY' named entity 'ASSOCIATED' named entity 'BLOOD-BRAIN BARRIER' named entity 'INTERFERON' named entity 'NEUROINFLAMMATION' named entity 'CD8' named entity 'NEUROINFLAMMATION' named entity 'RECRUITMENT' named entity 'DEPENDENT' named entity 'PATIENTS' named entity 'CORONAVIRUS' named entity 'LESIONS' named entity 'INFILTRATION' named entity 'LEUCOCYTE' named entity 'RESTRICTS' named entity 'MEMORY' named entity 'ENDOTHELIUM' named entity 'CHEMOKINE' named entity 'ALCAM' named entity 'MIGRATION' named entity 'INDEPENDENT OF' named entity 'EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS' named entity 'EXACT' named entity 'MOG' named entity 'INDUCED' named entity 'STUDY' named entity 'VERY LATE ANTIGEN-4' named entity 'LATE' named entity 'HUMAN' named entity 'VLA' named entity 'PROVIDE' named entity 'IN VITRO' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'T LYMPHOCYTES' named entity 'LEUKOCYTE' named entity 'UNKNOWN' named entity 'FUNCTION' named entity 'IN VIVO' named entity 'SELECTIVE' named entity 'MEMORY PHENOTYPE' named entity 'ACTIVATED' named entity 'ACTIVE ROLE' named entity 'THESE'

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