About: Crystal structure of the SARS-CoV-2 non-structural protein 9, Nsp9

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About: Crystal structure of the SARS-CoV-2 non-structural protein 9, Nsp9 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Crystal structure of the SARS-CoV-2 non-structural protein 9, Nsp9
Creator	Rossjohn, Jamie Colson, Rhys Gully, Benjamin Littler, Dene
Source	Elsevier; Medline; PMC
abstract	Summary Many of the SARS-CoV-2 proteins have related counterparts across the Severe Acute Respiratory Syndrome (SARS-CoV) family. One such protein is non-structural protein 9 (Nsp9), which is thought to mediate viral replication, overall virulence and viral genomic RNA reproduction. We sought to better characterise the SARS-CoV-2 Nsp9 and subsequently solved its X-ray crystal structure, in an apo-form and, unexpectedly, in a peptide-bound form with a sequence originating from a rhinoviral 3C protease sequence (LEVL). The SARS-CoV-2 Nsp9 structure revealed the high level of structural conservation within the Nsp9 family. The exogenous peptide binding site is close to the dimer interface and impacted the relative juxtapositioning of the monomers within the homodimer. We have established a protocol for the production of SARS-CoV-2 Nsp9, determined its structure and identified a peptide-binding site that warrants further study to understanding Nsp9 function.
has issue date	2020-06-09(xsd:dateTime)
bibo:doi	10.1016/j.isci.2020.101258
bibo:pmid	32592996
has license	els-covid
sha1sum (hex)	525b12c03f6df45e0a06abdfff506f88949e91fd
schema:url	https://doi.org/10.1016/j.isci.2020.101258
resource representing a document's title	Crystal structure of the SARS-CoV-2 non-structural protein 9, Nsp9
has PubMed Central identifier	PMC7282741
has PubMed identifier	32592996
schema:publication	iScience
resource representing a document's body	covid:525b12c03f6df45e0a06abdfff506f88949e91fd#body_text
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