About: Adipogenesis in ducks interfered by small interfering ribonucleic acids of peroxisome proliferator-activated receptor γ gene

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About: Adipogenesis in ducks interfered by small interfering ribonucleic acids of peroxisome proliferator-activated receptor γ gene Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Adipogenesis in ducks interfered by small interfering ribonucleic acids of peroxisome proliferator-activated receptor γ gene
Creator	Feng, Y Gong, Y Li, S Peng, X Xin, Q Xiong, M Yu, G
Source	Elsevier; Medline; PMC
abstract	ABSTRACT Peroxisome proliferator-activated receptor γ (PPARγ) participates in adipocyte differentiation and maintenance, including the promotion of lipid storage in mammals. In the present study, 3 duck PPARγ small interfering RNA (siRNA) expression plasmids were constructed to investigate the effect of downregulating the expression of PPARγ on adipogenesis and fat accumulation in ducks. The results indicate that the 3 siRNA specific for conserved regions of PPARγ can effectively inhibit expression of PPARγ. It was demonstrated that the expression of lipoprotein lipase and adipocyte fatty acid-binding protein in duck adipose tissue is repressed when the expression of PPARγ is downregulated by siRNA. At the same time, the weight of abdominal fat at 21 and 35 d of age is decreased significantly (P < 0.05) compared with the control. However, the triglyceride levels in serum and muscle are not affected when the mRNA of PPARγ is repressed. The current study indicates that the suppression of PPARγ reduces abdominal fat deposition and regulates adipogenesis in ducks.
has issue date	2010-01-01(xsd:dateTime)
bibo:doi	10.3382/ps.2009-00289
bibo:pmid	20008806
has license	els-covid
sha1sum (hex)	50bc887859439b9448360f00fb513d3752a5eb01
schema:url	https://doi.org/10.3382/ps.2009-00289
resource representing a document's title	Adipogenesis in ducks interfered by small interfering ribonucleic acids of peroxisome proliferator-activated receptor γ gene
has PubMed Central identifier	PMC7107157
has PubMed identifier	20008806
schema:publication	Poultry Science
resource representing a document's body	covid:50bc887859439b9448360f00fb513d3752a5eb01#body_text
is schema:about of	named entity 'reduces' named entity 'expression' named entity 'fat' named entity 'conserved regions' named entity 'differentiation' named entity 'adipogenesis' named entity 'age' named entity 'PPARγ' named entity 'ADIPOGENESIS' named entity 'INTERFERING' named entity 'PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR' named entity 'SMALL' named entity 'DUCKS' named entity 'DUCKS' named entity 'DUCK' named entity 'ADIPOCYTE' named entity 'CURRENT' named entity 'SIRNA' named entity 'ADIPOGENESIS' named entity 'EXPRESSION' named entity 'DECREASED' named entity 'WEIGHT' named entity 'MAMMALS' named entity 'LIPOPROTEIN LIPASE' named entity 'PRESENT' named entity 'PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR' named entity 'TO INVESTIGATE' named entity 'REGIONS' named entity 'ADIPOSE TISSUE' named entity 'PROTEIN ' named entity '0.05' named entity 'MUSCLE' named entity 'SERUM' named entity 'CONSERVED' named entity 'TIME' named entity 'PPAR' named entity 'GENE' named entity 'REPRESSED' named entity 'INTERFERED BY' named entity 'RIBONUCLEIC ACIDS' named entity 'MRNA' named entity 'CONSTRUCTED' named entity 'STUDY' named entity 'SMALL INTERFERING RNA' named entity 'ADIPOCYTE DIFFERENTIATION' named entity 'EFFECT' named entity 'FAT DEPOSITION' named entity 'LIPID STORAGE' named entity 'FATTY ACID-BINDING PROTEIN' named entity 'INCLUDING' named entity '28P' named entity 'PROMOTION' named entity 'PLASMIDS' named entity 'SUPPRESSION' named entity 'AFFECTED' named entity 'SPECIFIC' named entity 'COMPARED' named entity 'AGE' named entity 'ABDOMINAL FAT' named entity 'FAT' named entity 'MAINTENANCE' named entity 'ACCUMULATION' named entity 'RESULTS' named entity 'TRIGLYCERIDE LEVELS' named entity 'CONTROL' named entity 'DEMONSTRATED' covid:arg/50bc887859439b9448360f00fb513d3752a5eb01 named entity 'PPARγ' named entity 'fat' named entity 'participates' named entity 'plasmids' named entity 'small interfering RNA' named entity 'constructed' named entity 'lipid' named entity 'mRNA'

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