About: Anti-radiation damage effect of polyethylenimine as a toll-like receptor 5 targeted agonist

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About: Anti-radiation damage effect of polyethylenimine as a toll-like receptor 5 targeted agonist Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Anti-radiation damage effect of polyethylenimine as a toll-like receptor 5 targeted agonist
Creator	Hu, Zhiqiang Wang, Kai Chen, Xiaojuan Chen, Zhongbin Xing, Yaling Tu, Jian Qian, Yuanyu Ren, Lening
Source	PMC
abstract	A number of agents are now available for use in protecting against ionizing radiation. These radiation-protective agents, however, have many adverse effects. Efforts have been made to develop new radiation-protective agents for medical application. Here, we investigated whether a compound, polyethylenimine (PEI), which activates Toll-like receptor 5 (TLR5)-mediated NF-kB signaling pathways, could have an anti-radiation effect on a mouse model. First, a cell-based screening model for an agonist of TLR5-mediated NF-kB pathway was established and then validated by activation of TLR5-mediated NF-kB luciferase reporter activity with a known TLR5 agonist, flagellin. We found that PEI induced dose-dependent activation of the TLR5-mediated NF-kB pathway, indicating that PEI is indeed a TLR5 agonist. Furthermore, the anti-radiation effect of polyethylenimine was assessed using a γ-ray total body irradiation (TBI) mouse model. Compared with the irradiation control, both survival time and survival rate were significantly improved in mice that received either a low dose of polyethylenimine (P= 0.019) or a high dose of polyethylenimine (P< 0.001). We also observed a positive correlation between animal body weight and survival time in mice that received a low dose of polyethylenimine, a high dose of polyethylenimine and amifostine, over a period of 30 days, r= 0.42 (P< 0.02), 0.72 (P< 0.0001) and 0.95 (P< 0.0001), respectively, while a negative correlation between animal body weight and survival time was observed in the irradiation control (r= –0.89; P< 0.0001). These results indicate that polyethylenimine is a new TLR5 agonist with potential application in offering protection for patients receiving radiotherapy or in radiation-related accidents.
has issue date	2012-10-26(xsd:dateTime)
bibo:doi	10.1093/jrr/rrs098
bibo:pmid	23104900
has license	cc-by-nc
sha1sum (hex)	4ea10ee40e0ecf02db0667f87ed9ee4e2bd6aa9c
schema:url	https://doi.org/10.1093/jrr/rrs098
resource representing a document's title	Anti-radiation damage effect of polyethylenimine as a toll-like receptor 5 targeted agonist
has PubMed Central identifier	PMC3589936
has PubMed identifier	23104900
schema:publication	J Radiat Res
resource representing a document's body	covid:4ea10ee40e0ecf02db0667f87ed9ee4e2bd6aa9c#body_text
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