About: Entry Inhibition of Influenza Viruses with High Mannose Binding Lectin ESA-2 from the Red Alga Eucheuma serra through the Recognition of Viral Hemagglutinin

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About: Entry Inhibition of Influenza Viruses with High Mannose Binding Lectin ESA-2 from the Red Alga Eucheuma serra through the Recognition of Viral Hemagglutinin Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Entry Inhibition of Influenza Viruses with High Mannose Binding Lectin ESA-2 from the Red Alga Eucheuma serra through the Recognition of Viral Hemagglutinin
Creator	Hirayama, Makoto Hori, Kanji Kubo, Takanori Morimoto, Kinjiro Nishizono, Akira Sakaguchi, Takemasa Sato, Yuichiro
Source	Medline; PMC
abstract	Lectin sensitivity of the recent pandemic influenza A virus (H1N1-2009) was screened for 12 lectins with various carbohydrate specificity by a neutral red dye uptake assay with MDCK cells. Among them, a high mannose (HM)-binding anti-HIV lectin, ESA-2 from the red alga Eucheuma serra, showed the highest inhibition against infection with an EC(50) of 12.4 nM. Moreover, ESA-2 exhibited a wide range of antiviral spectrum against various influenza strains with EC(50)s of pico molar to low nanomolar levels. Besides ESA-2, HM-binding plant lectin ConA, fucose-binding lectins such as fungal AOL from Aspergillus oryzae and AAL from Aleuria aurantia were active against H1N1-2009, but the potency of inhibition was of less magnitude compared with ESA-2. Direct interaction between ESA-2 and a viral envelope glycoprotein, hemagglutinin (HA), was demonstrated by ELISA assay. This interaction was effectively suppressed by glycoproteins bearing HM-glycans, indicating that ESA-2 binds to the HA of influenza virus through HM-glycans. Upon treatment with ESA-2, no viral antigens were detected in the host cells, indicating that ESA-2 inhibited the initial steps of virus entry into the cells. ESA-2 would thus be useful as a novel microbicide to prevent penetration of viruses such as HIV and influenza viruses to the host cells.
has issue date	2015-05-29(xsd:dateTime)
bibo:doi	10.3390/md13063454
bibo:pmid	26035023
has license	cc-by
sha1sum (hex)	4e83f87fdf5b15fb7962c1b6235b520817924a9b
schema:url	https://doi.org/10.3390/md13063454
resource representing a document's title	Entry Inhibition of Influenza Viruses with High Mannose Binding Lectin ESA-2 from the Red Alga Eucheuma serra through the Recognition of Viral Hemagglutinin
has PubMed Central identifier	PMC4483639
has PubMed identifier	26035023
schema:publication	Mar Drugs
resource representing a document's body	covid:4e83f87fdf5b15fb7962c1b6235b520817924a9b#body_text
is schema:about of	named entity 'LECTINS' named entity 'ASSAY' named entity 'ELISA ASSAY' named entity 'NANOMOLAR' named entity 'SENSITIVITY' named entity 'ALEURIA AURANTIA' named entity 'LEVELS' named entity '12.4' named entity 'VARIOUS' named entity 'HIGH' named entity 'PICO' named entity 'AAL' named entity 'SPECIFICITY' named entity 'INDICATING' named entity 'VIRAL ENVELOPE' named entity 'MOLAR' named entity 'HIGHEST' named entity 'HEMAGGLUTININ' named entity 'UPTAKE' named entity 'FUCOSE' named entity 'BINDING' named entity 'POTENCY' named entity 'COMPARED' named entity 'virus' named entity 'red alga' named entity 'interaction' named entity 'Viral' named entity 'HEMAGGLUTININ' named entity 'INHIBITION' named entity 'CARBOHYDRATE' named entity 'H1N1' named entity 'DIRECT INTERACTION' named entity 'RANGE' named entity 'INFLUENZA VIRUS' named entity 'ASPERGILLUS ORYZAE' named entity 'INHIBITION' named entity 'EC50' named entity 'ENVELOPE GLYCOPROTEIN' named entity 'LOW' named entity 'INTERACTION' named entity 'CONA' named entity 'NEUTRAL RED' named entity 'ESA' named entity 'WIDE' named entity 'VIRAL' named entity 'DRUGS' named entity 'ESA' named entity 'RED' named entity 'HIGH' named entity 'INFLUENZA VIRUSES' named entity 'RECOGNITION' named entity 'MARINE' named entity 'MANNOSE BINDING LECTIN' named entity 'EUCHEUMA SERRA' named entity 'PLANT LECTIN' named entity 'DEMONSTRATED' named entity 'MAGNITUDE' named entity 'ANTI-HIV' named entity 'SUPPRESSED' named entity 'ANTIVIRAL' named entity 'STRAINS' named entity 'LECTIN' named entity 'INFECTION' named entity 'ALGA' named entity 'ENTRY' named entity 'ALGA' named entity 'GLYCANS' named entity 'MDCK CELLS' named entity 'EUCHEUMA SERRA' named entity 'RED' named entity 'BUT' named entity 'MANNOSE' named entity 'SPECTRUM' named entity 'ACTIVE' named entity 'BEARING'

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