About: Molecular Characterization of HE, M, and E Genes of Winter Dysentery Bovine Coronavirus Circulated in Korea During 2002

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About: Molecular Characterization of HE, M, and E Genes of Winter Dysentery Bovine Coronavirus Circulated in Korea During 2002–2003 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular Characterization of HE, M, and E Genes of Winter Dysentery Bovine Coronavirus Circulated in Korea During 2002–2003
Creator	Cho, Kyoung-Oh Kim, Ha-Hyun Kim, Sang-Ki Park, Su-Jin Ae, Jeong Ae, Kim Ae, Park Ae, Sung-Hee Ae, Yoon Cheol, A Geum, A Gye-Yeop, A Jae-Ho, A Kang, Ae Mun-Il Kim, Jung Ko, Chin-Koo Kyoung-Yoon, A Lim, Ki Park, Jong-Tae Sang-Ilk, A
Source	Medline; PMC
abstract	The different bovine coronavirus (BCoV) strains or isolates exhibited various degrees of substitutions, resulting in altered antigenicity and pathogenicity of the virus. In the previous our study, we demonstrated that the spike glycoprotein gene of Korean winter dysentery (WD) BCoV had a genetic property of both enteric (EBCV) and respiratory BCoV (RBCV) and were significantly distinct from the ancestral enteric strains. In the present study, therefore, we analyzed the other structure genes, the hemagglutinin/esterase (HE) protein, the transmembrane (M) protein and the small membrane (E) protein to characterize 10 WD BCoV circulated in Korea during 2002–2003 and compared the nucleotide and deduced amino acid sequences with the other known BCoV. Phylogenetic analysis indicated that the HE gene among BCoV could be divided into three groups. The first group included only RBCV, while the second group contained calf diarrhea BCoV, RBCV, WD and EBCV, respectively. The third group possessed only all Korean WD strains which were more homologous to each other and were sharply distinct from the other known BCoV, suggesting Korean WD strains had evolutionary distinct pathway. In contrast, the relative conservation of the M and E proteins of BCoV including Korean WD strains and the other coronaviruses suggested that structural constraints on these proteins are rigid, resulting in more limited evolution of these proteins. In addition, BCoV and human coronavirus HCV-OC43 contained four potential O-glycosylation sites in the M gene. However, the M gene sequence of both BCoV and HCV-OC43 might not contain a signal peptide, suggesting the M protein might be unlikely to be exposed to the O-glycosylation machinery in vivo.
has issue date	2006-01-01(xsd:dateTime)
bibo:doi	10.1007/s11262-005-6867-3
bibo:pmid	16604443
has license	no-cc
sha1sum (hex)	4c43a6f65de921cb08cfff344d152b99f76687eb
schema:url	https://doi.org/10.1007/s11262-005-6867-3
resource representing a document's title	Molecular Characterization of HE, M, and E Genes of Winter Dysentery Bovine Coronavirus Circulated in Korea During 2002–2003
has PubMed Central identifier	PMC7089456
has PubMed identifier	16604443
schema:publication	Virus Genes
resource representing a document's body	covid:4c43a6f65de921cb08cfff344d152b99f76687eb#body_text
is schema:about of	named entity 'MOLECULAR' named entity 'PROPERTY' named entity 'RELATIVE' named entity 'POSSESSED' named entity 'SMALL' named entity 'PROTEIN' named entity 'BOVINE CORONAVIRUS' named entity 'GROUP' named entity 'PROTEINS' named entity 'M GENE' named entity 'PREVIOUS' named entity 'MEMBRANE' named entity 'STRAINS' named entity 'WINTER' named entity 'GENETIC' named entity 'COULD BE' named entity 'CONTAINED' named entity 'SIGNAL PEPTIDE' named entity 'KOREAN' named entity 'UNLIKELY' named entity 'VARIOUS' named entity 'CALF' named entity 'ISOLATES' named entity 'ALTERED' named entity 'INCLUDED' named entity 'CORONAVIRUSES' named entity 'HUMAN CORONAVIRUS' named entity 'OUR' named entity 'ANALYZED' named entity 'PATHOGENICITY' named entity 'SITES' named entity 'DISTINCT FROM' named entity 'PATHWAY' named entity 'RESULTING IN' named entity 'INCLUDING' covid:arg/4c43a6f65de921cb08cfff344d152b99f76687eb named entity 'KOREA' named entity 'GROUPS' named entity 'STRUCTURAL' named entity 'POTENTIAL' named entity 'CIRCULATED' named entity 'EXPOSED TO' named entity 'LIMITED' named entity 'STRUCTURE' named entity 'TO CHARACTERIZE' named entity 'STUDY' named entity 'ADDITION' named entity 'VIRUS' named entity 'TRANSMEMBRANE' named entity 'CONTAIN' named entity 'MACHINERY' named entity 'PHYLOGENETIC ANALYSIS' named entity 'THESE' named entity 'RIGID' named entity 'CONTRAST' named entity 'INDICATED' named entity 'CHARACTERIZATION' named entity 'ENTERIC' named entity 'KNOWN' named entity 'CIRCULATED' named entity 'WINTER DYSENTERY BOVINE CORONAVIRUS' named entity 'CONSERVATION'

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