About: Immunohistochemical Localization and MRNA Detection of Rab3D and/or Rab3B in rat von Ebner's Glands, Parotid Gland, Pancreas, and Liver

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About: Immunohistochemical Localization and MRNA Detection of Rab3D and/or Rab3B in rat von Ebner's Glands, Parotid Gland, Pancreas, and Liver Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunohistochemical Localization and MRNA Detection of Rab3D and/or Rab3B in rat von Ebner's Glands, Parotid Gland, Pancreas, and Liver
Creator	Field, Ruth Redman, Robert Kruse, David
Source	Medline; PMC
abstract	In examining the secretory mechanism of exocrine glands, we focused on the small GTP-binding proteins, Rab3D and Rab3B, which function in the final steps of exocytosis in non-neuronal tissues. These proteins were observed in von Ebner's glands by (32)P-GTP overlay. mRNA isolated from von Ebner's glands, the pancreas, parotid glands, and liver was subjected to reverse transcription PCR and probed with primers and nested primers for Rab3D and Rab3B. Rab3D was found in all three exocrine glands and the liver, while Rab3B was found in the liver. Utilizing immunofluorescence histochemistry, Rab3D was localized to hepatocytes of the liver and to secretory granules of the exocrine glands, and Rab3B to liver and pancreatic islets. Isoproterenol evoked decreases in α-amylase- and Rab3D-labelled parotid secretory granules, and pilocarpine stimulated decreases in secretory granules labelled for lingual lipase and Rab3D from von Ebner's glands, and amylase and Rab3D from pancreas. Neither secretagogue affected Rab3B in pancreatic islets. These observed parallel decreases in response to β-adrenergic (parotid) or cholinergic (von Ebner's and pancreas) secretagogues indicate that the function of Rab3D in exocytosis in these exocrine organs is similar and that the type of secretagogue does not determine the function.
has issue date	2001-01-01(xsd:dateTime)
bibo:doi	10.1023/a:1017992012962
bibo:pmid	11432642
has license	no-cc
sha1sum (hex)	4b057f2e94bf79f235752c084bd4ade18fb60ea2
schema:url	https://doi.org/10.1023/a:1017992012962
resource representing a document's title	Immunohistochemical Localization and MRNA Detection of Rab3D and/or Rab3B in rat von Ebner's Glands, Parotid Gland, Pancreas, and Liver
has PubMed Central identifier	PMC7088391
has PubMed identifier	11432642
schema:publication	Histochem J
resource representing a document's body	covid:4b057f2e94bf79f235752c084bd4ade18fb60ea2#body_text
is schema:about of	named entity 'Isoproterenol' named entity 'exocytosis' named entity 'parotid' named entity 'parotid glands' named entity 'liver' named entity 'glands' named entity 'liver' named entity 'labelled' named entity 'parotid gland' named entity 'EXOCRINE GLANDS' named entity 'SECRETORY' named entity 'CHOLINERGIC' named entity 'GTP' named entity 'LIPASE' covid:arg/4b057f2e94bf79f235752c084bd4ade18fb60ea2 named entity 'immunofluorescence' named entity 'tissues' named entity 'organs' named entity 'proteins' named entity 'observed' named entity 'exocrine' named entity 'function' named entity 'localized' named entity 'pancreas' named entity 'amylase' named entity 'exocrine glands' named entity 'function' named entity 'exocrine glands' named entity 'secretory granules' named entity 'amylase' named entity 'exocrine glands' named entity 'secretagogue' named entity 'liver' named entity 'primers' named entity 'primers' named entity 'von Ebner's glands' named entity 'hepatocytes' named entity 'neuronal tissues' named entity 'small GTP-binding proteins' named entity 'Immunohistochemical' named entity 'parotid glands' named entity 'histochemistry' named entity 'glycerols' named entity 'amylase' named entity 'exocytotic' named entity 'primers' named entity 'salivary amylase' named entity 'cholinergic' named entity '0.49' named entity 'pancreas' named entity 'liver' named entity 'exocrine pancreas' named entity 'liver' named entity 'SDS-PAGE' named entity 'Rab3B' named entity 'lingual lipase' named entity 'positive controls' named entity 'intraperitoneal injection' named entity 'rtPCR' named entity 'amylase' named entity 'liver' named entity 'mRNA' named entity 'phosphate buffer' named entity 'liver' named entity 'primers' named entity 'Antibodies' named entity 'non-specific' named entity 'exocrine pancreas' named entity 'cross-reaction' named entity 'minor salivary glands' named entity 'rat' named entity 'Rabs' named entity 'small GTP-binding proteins' named entity 'rat' named entity 'insulin' named entity 'pancreas' named entity 'propranolol' named entity 'intraperitoneally' named entity 'amylase'

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