About: Multisystem inflammatory syndrome in children (MIS-C): Report of the clinical and epidemiological characteristics of cases in Santiago de Chile during the SARS-CoV-2 pandemic

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About: Multisystem inflammatory syndrome in children (MIS-C): Report of the clinical and epidemiological characteristics of cases in Santiago de Chile during the SARS-CoV-2 pandemic Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Multisystem inflammatory syndrome in children (MIS-C): Report of the clinical and epidemiological characteristics of cases in Santiago de Chile during the SARS-CoV-2 pandemic
Creator	Tapia, Lorena Torres, Juan Acuña, Mirta Contardo, Verónica Fritis, Ana González, Ricardo Izquierdo, Giannina Pavez, Daniela Reyes, Felipe Ribacova, Carolina
Source	Elsevier; PMC
abstract	OBJECTIVE: To describe the clinical and epidemiological characteristics of hospitalized children with Multisystem Inflammatory Syndrome in Children (MIS-C) in Santiago, Chile. METHODS: Observational study, on children with MIS-C (May 1- June 24, 2020), in 3 pediatric hospitals in Santiago. Demographics and epidemiologic data; medical history; laboratory tests; cardiologic evaluation; treatment; and clinical outcome were analyzed. RESULTS: 27 patients (median age 6 (0-14) years) were admitted; 16/27 (59%) required intensive care admission with no deaths. 74% had no-comorbidities, and median days of symptoms before admission was 4 (2-9). Gastrointestinal symptoms were the most frequent, and inflammatory markers were increased at admission. A recent SARS-CoV-2 infection was detected in 82% of cases. The severe group showed significantly lower hemoglobin and albumin, decreased platelet counts, and higher D-dimer during evolution. Echocardiography showed abnormalities (myocardial, pericardial, or coronary) on 12 patients (46%) during hospital stay. Anti-inflammatory treatment (immune globulin and/or corticosteroids) was prescribed in 24 patients. MIS-C appeared in clusters weeks after the peak of SARS-CoV-2 cases, especially in Santiago's most vulnerable areas. CONCLUSIONS: We describe the first series, of 27 children with MIS-C, in a Latin-American countrywith favorable clinical outcomes. Education and alerts are required for clinical teams to establish an early diagnosis and prompt treatment.
has issue date	2020-08-28(xsd:dateTime)
bibo:doi	10.1016/j.ijid.2020.08.062
has license	no-cc
sha1sum (hex)	4a622dd96845564037f45ed033b05b4cf9cadc6d
schema:url	https://doi.org/10.1016/j.ijid.2020.08.062
resource representing a document's title	Multisystem inflammatory syndrome in children (MIS-C): Report of the clinical and epidemiological characteristics of cases in Santiago de Chile during the SARS-CoV-2 pandemic
has PubMed Central identifier	PMC7452906
schema:publication	Int J Infect Dis
resource representing a document's body	covid:4a622dd96845564037f45ed033b05b4cf9cadc6d#body_text
is schema:about of	named entity 'Gastrointestinal' named entity 'CLINICAL OUTCOMES' named entity 'AREAS' named entity 'CASES' named entity 'Chile' named entity 'Although' named entity 'teams' named entity 'epidemiological' named entity 'clusters' named entity 'medical history' named entity 'weeks' named entity 'diabetes' named entity 'COVID-19' named entity 'Observational study' named entity 'Santiago de Chile' named entity 'Journal' named entity 'Multisystem' named entity 'laboratory tests' named entity 'clinical outcome' named entity 'inflammatory' named entity 'Multisystem inflammatory syndrome' named entity 'SARS-CoV-2 pandemic' named entity 'epidemiological' named entity 'vulnerable' named entity 'invasive mechanical ventilation' named entity 'incidence rate' named entity 'arrhythmias' named entity 'dyspnea' named entity 'diarrhea' named entity 'Coronavirus' named entity 'MIS' named entity 'neurological' named entity 'United States' named entity 'MIS-C' named entity 'World Bank' named entity 'comorbidities' named entity 'urban area' named entity 'allergies' named entity 'echocardiogram' named entity 'coronary arteries' named entity 'chronic heart' named entity 'developing countries' named entity 'cardiac biomarkers' named entity 'fever' named entity 'Universidad de Chile' named entity 'runny nose' named entity 'lymphopenia' named entity 'immunosuppression' named entity 'epidemiological' named entity 'cough' named entity 'neurological' named entity 'electronic data capture' named entity 'Institutional Review Boards' named entity 'mechanical ventilation' named entity 'case fatality rate' named entity 'diarrhea' named entity 'CRP' named entity 'Coronavirus' named entity 'corticosteroids' named entity 'coronary arteries' named entity 'corticosteroids' named entity 'PICU' named entity 'gastrointestinal symptoms' named entity 'biomarkers' named entity 'Chile' named entity 'adverse outcome' named entity 'vital signs' named entity 'follow-up' named entity 'early diagnosis' named entity '12/26' named entity 'acute respiratory failure' named entity 'D-dimer' named entity '13.5' named entity 'interleukin-6'

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