About: Potent and Selective Activity against Human Immunodeficiency Virus 1 (HIV-1) of Thymelaea hirsuta Extracts

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Potent and Selective Activity against Human Immunodeficiency Virus 1 (HIV-1) of Thymelaea hirsuta Extracts
Creator	Madeddu, Silvia Sanna, Giuseppina Galdiero, Marilena Franci, Gianluigi Begala, Michela Caboni, Pierluigi Giliberti, Gabriele Incani, Alessandra Murgia, Giuseppe Serreli, Gabriele
topic	covid:49592764bc9d8a7bee302f001ccdf29c436c6dde#this
source	Medline; PMC
abstract	Historically, natural products have been the most successful source of inspiration for the development of new drugs. Members of the Thymelaeaceae family have been of interest owing to their excellent medicinal value. Given the successful history of natural product-based drug discovery, extracts from the aerial parts of Thymelaea hirsuta were evaluated for their potential anti-human immunodeficiency virus type 1 (HIV-1) activity. Ethyl acetate extracts from leaves (71B) and branches (72B) of Thymelaea hirsuta showed potent and selective activity against HIV-1 wt (EC(50) = 0.8 µg/mL) at non-cytotoxic concentrations (CC(50) > 100 µg/mL). They proved to be active against HIV-1 variants carrying clinically relevant NNRTI and NRTI mutations at low concentration (0.3–4 µg/mL range) and against the M-tropic strain HIV-1 BaL. The 72B extract, chosen as a lead, was not able to inhibit the RT and protease enzymatic functions. Furthermore, it was not virucidal, since exposure of HIV to high concentration did not affect virus infectivity. The pre-clinical safety profile of this extract showed no adverse effect on the growth of Lactobacilli, and non-toxic concentration of the extract did not influence the Caco-2 epithelial cells monolayer integrity. Additionally, extract 72B prevented syncytia formation at low concentration (0.4 µg/mL). The potent inhibitory effect on the syncytia formation in co-cultures showed that 72B inhibits an early event in the replication cycle of HIV. All of these findings prompt us to carry on new studies on Thymelaea hirsuta extracts.
has issue date	2020-06-19(xsd:dateTime)
bibo:doi	10.3390/v12060664
bibo:pmid	32575585
has license	cc-by
sha1sum (hex)	49592764bc9d8a7bee302f001ccdf29c436c6dde
schema:url	https://doi.org/10.3390/v12060664
resource representing a document's title	Potent and Selective Activity against Human Immunodeficiency Virus 1 (HIV-1) of Thymelaea hirsuta Extracts
has PubMed Central identifier	PMC7354558
has PubMed identifier	32575585
schema:publication	Viruses
resource representing a document's body	covid:49592764bc9d8a7bee302f001ccdf29c436c6dde#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/49592764bc9d8a7bee302f001ccdf29c436c6dde
is schema:about of	named entity 'history' named entity 'HIV' named entity 'Lactobacilli' named entity 'infectivity' named entity 'HIV-1' named entity 'excellent' named entity 'Thymelaea hirsuta' named entity 'virus' named entity 'natural products' named entity 'extracts' named entity 'epithelial cells' named entity 'immunodeficiency' named entity 'Thymelaea hirsuta' named entity 'EtOAc' named entity 'co-receptor' named entity 'vaginal microflora' named entity '0.01' named entity 'high' named entity 'NRTI' named entity 'potential' named entity 'inspiration' named entity 'prevented' named entity 'non-toxic' named entity 'syncytia' named entity 'Thymelaea hirsuta' named entity 'human immunodeficiency virus type 1' named entity 'replication cycle' named entity 'Caco-2' named entity 'drug discovery' named entity 'NNRTI' named entity 'infectivity' named entity 'cytotoxic' named entity 'HIV-1' named entity 'Viruses' named entity 'inhibitory activity' named entity 'mode of action' named entity 'plant extracts' named entity 'viruses' named entity 'shrub' named entity 'HIV-1' named entity 'virus' named entity 'viruses' named entity 'co-receptor' named entity 'CD4' named entity 'acetone' named entity 'gp120' named entity 'negative-sense' named entity 'Italy' named entity 'Picornaviridae' named entity 'CD4' named entity 'HIV-1' named entity 'diterpenes' named entity 'serum' named entity 'New York' named entity 'petroleum ether' named entity 'HIV' named entity 'HIV-1 infection' named entity 'HIV' named entity 'Senorbì' named entity 'diterpenes' named entity 'Nevirapine' named entity 'Cell culture' named entity 'FBS' named entity 'World Health Organization' named entity 'RSV' named entity 'voltmeter' named entity 'phytotherapy' named entity 'Exponentially growing' named entity 'silica gel' named entity 'incubation period'

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