About: Characterization of coronavirus JHM variants isolated from wistar furth rats with a viral-induced demyelinating disease

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About: Characterization of coronavirus JHM variants isolated from wistar furth rats with a viral-induced demyelinating disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Characterization of coronavirus JHM variants isolated from wistar furth rats with a viral-induced demyelinating disease
Creator	Morris, Vincent Mackinnon, Joanne Percyt, Dean
source	Elsevier; Medline; PMC
abstract	Abstract Murine hepatitis virus (MHV) can cause neurological disease when inoculated intracerebrally (ic) into mice and rats. Specifically the JHM strain of MHV (MHV-JHM) generally causes an acute encephalitis when inoculated is into 2-day-old Wistar Furth rats. In contrast, JHM generally produces a chronic demyelinating disease with resulting posterior paralysis when inoculated is into 10-day-old Wistar Furth rats. In addition, while JHM readily produces a productive infection in a mouse fibroblast cell line (L-2), it does not form syncytia or replicate well in a tissue cell line of glial origin (G26-24). We have isolated and characterized three MHV-JHM viral variants from the central nervous system of two Wistar Furth rats with a MHV-JHM-induced demyelinating disease. The pattern of viral-specific mRNA for all three of these variants differed from what was observed for the wild-type parental MHV-JHM that had been passaged only in tissue culture. One of these variants, ATIIf cord virus, which induced a chronic demyelinating disease in 2- or 10-day-old intracerebrally inoculated Wistar Furth rats, had a deletion in the coding region of the peplomer glycoprotein mRNA. In addition, this variant formed massive syncytia and replicated well in G26-24 cells. We have not detected this deletion in the other two JHM variants, ATIIf brain virus and ATIIe brain virus. ATIIf brain virus and ATIIe brain virus primarily produced an acute encephalitis when reinoculated into 2-or 10-day-old Wistar Furth rats. In addition, these two variants did not form syncytia and had a reduced ability to replicate in G26-24 cells.
has issue date	1989-03-31(xsd:dateTime)
bibo:doi	10.1016/0042-6822(89)90048-2
bibo:pmid	2538027
has license	els-covid
sha1sum (hex)	49528bcccaed92a1bf66fdc108109bfe2a48e9a0
schema:url	https://doi.org/10.1016/0042-6822%2889%2990048-2
resource representing a document's title	Characterization of coronavirus JHM variants isolated from wistar furth rats with a viral-induced demyelinating disease
has PubMed Central identifier	PMC7131095
has PubMed identifier	2538027
schema:publication	Virology
resource representing a document's body	covid:49528bcccaed92a1bf66fdc108109bfe2a48e9a0#body_text
is schema:about of	named entity 'strain' named entity 'tissue culture' named entity 'virus' named entity 'Furth' named entity 'cell' named entity 'rats' named entity 'neurological disease' named entity 'RATS' named entity 'TISSUE' named entity 'VARIANT' named entity 'DEMYELINATING DISEASE' named entity 'TISSUE CULTURE' named entity 'GLYCOPROTEIN' named entity 'CONTRAST' named entity 'FORM' named entity 'PATTERN' named entity 'STRAIN' named entity 'ACUTE ENCEPHALITIS' named entity 'VIRAL' named entity 'ADDITION' named entity 'GLIAL' named entity 'MASSIVE' named entity 'CAUSE' named entity 'NEUROLOGICAL DISEASE' named entity 'CHRONIC' named entity 'ISOLATED' named entity 'RESULTING' named entity 'NOT DETECTED' named entity 'OBSERVED' named entity 'A MOUSE' named entity 'CHARACTERIZED' named entity 'HAVE' named entity 'PARENTAL' named entity 'VARIANTS' named entity 'FORMED' named entity 'WHAT' named entity 'SYNCYTIA' named entity 'DELETION' named entity 'ORIGIN' named entity 'VIRAL-' named entity 'FIBROBLAST CELL LINE' named entity 'GENERALLY' named entity 'G26' named entity 'ONE OF' named entity 'MURINE HEPATITIS VIRUS' named entity 'VIRUS' named entity 'DOES NOT' named entity 'CELLS' named entity 'DAY-OLD' named entity 'REDUCED' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'RATS' named entity 'ACUTE' named entity 'PRODUCTIVE' named entity 'INDUCED' named entity 'CORD' named entity 'ISOLATED' named entity 'WISTAR FURTH' named entity 'CORONAVIRUS' named entity 'CODING REGION' named entity 'BRAIN' named entity 'CAUSES' named entity 'THESE' named entity 'VIRAL-' named entity 'PARALYSIS' named entity 'INDUCED' named entity 'SPECIFIC' named entity 'WISTAR FURTH' named entity 'POSTERIOR' named entity 'MOUSE FIBROBLAST' named entity 'CELL LINE' named entity 'INFECTION' named entity 'MICE' named entity 'REPLICATE' named entity 'DID' named entity 'MRNA' named entity 'WILD-TYPE' named entity 'CHARACTERIZATION' named entity 'DEMYELINATING DISEASE'

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