About: Differential Sensitivity of Bat Cells to Infection by Enveloped RNA Viruses: Coronaviruses, Paramyxoviruses, Filoviruses, and Influenza Viruses

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About: Differential Sensitivity of Bat Cells to Infection by Enveloped RNA Viruses: Coronaviruses, Paramyxoviruses, Filoviruses, and Influenza Viruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Differential Sensitivity of Bat Cells to Infection by Enveloped RNA Viruses: Coronaviruses, Paramyxoviruses, Filoviruses, and Influenza Viruses
Creator	Thiel, Volker Herrler, Georg Drosten, Christian Binger, Tabea Deng, Hongkui Erdt, Meike Esser, Karl-Heinz Hoffmann, Markus Losemann, Christoph Schwegmann-Weßels, Christel Gallen, St Hospital, Kantonal Felix Drexler, Jan Gü Tzkow, Tim Mü Ller, Marcel Rg Glende, Jö
Source	Medline; PMC
abstract	Bats (Chiroptera) host major human pathogenic viruses including corona-, paramyxo, rhabdo- and filoviruses. We analyzed six different cell lines from either Yinpterochiroptera (including African flying foxes and a rhinolophid bat) or Yangochiroptera (genera Carollia and Tadarida) for susceptibility to infection by different enveloped RNA viruses. None of the cells were sensitive to infection by transmissible gastroenteritis virus (TGEV), a porcine coronavirus, or to infection mediated by the Spike (S) protein of SARS-coronavirus (SARS-CoV) incorporated into pseudotypes based on vesicular stomatitis virus (VSV). The resistance to infection was overcome if cells were transfected to express the respective cellular receptor, porcine aminopeptidase N for TGEV or angiotensin-converting enzyme 2 for SARS-CoV. VSV pseudotypes containing the S proteins of two bat SARS-related CoV (Bg08 and Rp3) were unable to infect any of the six tested bat cell lines. By contrast, viral pseudotypes containing the surface protein GP of Marburg virus from the family Filoviridae infected all six cell lines though at different efficiency. Notably, all cells were sensitive to infection by two paramyxoviruses (Sendai virus and bovine respiratory syncytial virus) and three influenza viruses from different subtypes. These results indicate that bat cells are more resistant to infection by coronaviruses than to infection by paramyxoviruses, filoviruses and influenza viruses. Furthermore, these results show a receptor-dependent restriction of the infection of bat cells by CoV. The implications for the isolation of coronaviruses from bats are discussed.
has issue date	2013-08-30(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0072942
bibo:pmid	24023659
has license	cc-by
sha1sum (hex)	4903f4b49cff9b009f9413ae245ecb75bd97960c
schema:url	https://doi.org/10.1371/journal.pone.0072942
resource representing a document's title	Differential Sensitivity of Bat Cells to Infection by Enveloped RNA Viruses: Coronaviruses, Paramyxoviruses, Filoviruses, and Influenza Viruses
has PubMed Central identifier	PMC3758312
has PubMed identifier	24023659
schema:publication	PLoS One
resource representing a document's body	covid:4903f4b49cff9b009f9413ae245ecb75bd97960c#body_text
is schema:about of	named entity 'surface' named entity 'coronaviruses' named entity 'influenza' named entity 'Marburg virus' named entity 'respective' named entity 'vesicular stomatitis virus' named entity 'viruses' named entity 'infected' named entity 'UNABLE TO' named entity 'RESTRICTION' covid:arg/4903f4b49cff9b009f9413ae245ecb75bd97960c named entity 'SARS-COV' named entity 'RESULTS' named entity 'SURFACE PROTEIN' named entity 'FILOVIRUSES' named entity 'INFECTED' named entity 'TO EXPRESS' named entity 'CORONAVIRUSES' named entity 'SENSITIVITY' named entity 'FILOVIRUSES' named entity 'VIRAL' named entity 'SPIKE' named entity 'BAT' named entity 'CITATION' named entity 'SENSITIVE TO' named entity 'ANALYZED' named entity 'CONTAINING' named entity 'CONTRAST' named entity 'FAMILY FILOVIRIDAE' named entity 'AMINOPEPTIDASE N' named entity 'PATHOGENIC' named entity 'PARAMYXOVIRUSES' named entity 'DIFFERENTIAL' named entity 'RNA VIRUSES' named entity 'BAT' named entity 'TADARIDA' named entity 'AFRICAN' named entity 'OVERCOME' named entity 'CELLULAR' named entity 'DIFFERENT' named entity 'SENSITIVITY' named entity 'INFECTION' named entity 'RESISTANT TO' named entity 'VIRUS' named entity 'EITHER' named entity 'RECEPTOR' named entity 'HOST' named entity 'RELATED' named entity 'CORONAVIRUSES' named entity '28S' named entity 'BOVINE RESPIRATORY SYNCYTIAL VIRUS' named entity 'CORONAVIRUS' named entity 'TESTED' named entity 'VIRUSES' named entity 'VESICULAR STOMATITIS VIRUS' named entity 'CORONA' named entity 'TO INFECT' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'ISOLATION' named entity 'PARAMYXOVIRUSES' named entity 'MAJOR' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'CELL LINES' named entity 'THESE' named entity 'INFLUENZA VIRUSES' named entity 'SUBTYPES'

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