About: Dynamic changes in circulating T follicular helper cell composition predict neutralising antibody responses after yellow fever vaccination

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About: Dynamic changes in circulating T follicular helper cell composition predict neutralising antibody responses after yellow fever vaccination Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Dynamic changes in circulating T follicular helper cell composition predict neutralising antibody responses after yellow fever vaccination
Creator	Hoelscher, Michael Lehmann, Lisa Krug, Anne Barba-Spaeth, Giovanna Von Sonnenburg, Frank Ahlfeld, Julia Baumjohann, Dirk Dick, Andrea Huber, Johanna Karimzadeh, Hadi Pritsch, Michael Rothenfußer, Simon Scheck, Magdalena Witter, Klaus Zaucha, Magdalena
source	Medline; PMC
abstract	OBJECTIVES: T follicular helper (Tfh) cells are the principal T helper cell subset that provides help to B cells for potent antibody responses against various pathogens. In this study, we took advantage of the live‐attenuated yellow fever virus (YFV) vaccine strain, YF‐17D, as a model system for studying human antiviral immune responses in vivo following exposure to an acute primary virus challenge under safe and highly controlled conditions, to comprehensively analyse the dynamics of circulating Tfh (cTfh) cells. METHODS: We tracked and analysed the response of cTfh and other T and B cell subsets in peripheral blood of healthy volunteers by flow cytometry over the course of 4 weeks after YF‐17D vaccination. RESULTS: Using surface staining of cell activation markers to track YFV‐specific T cells, we found increasing cTfh cell frequencies starting at day 3 and peaking around 2 weeks after YF‐17D vaccination. This kinetic was confirmed in a subgroup of donors using MHC multimer staining for four known MHC class II epitopes of YF‐17D. The subset composition of cTfh cells changed dynamically during the course of the immune response and was dominated by the cTfh1‐polarised subpopulation. Importantly, frequencies of cTfh1 cells correlated with the strength of the neutralising antibody response, whereas frequencies of cTfh17 cells were inversely correlated. CONCLUSION: In summary, we describe detailed cTfh kinetics during YF‐17D vaccination. Our results suggest that cTfh expansion and polarisation can serve as a prognostic marker for vaccine success. These insights may be leveraged in the future to improve current vaccine design and strategies.
has issue date	2020-05-13(xsd:dateTime)
bibo:doi	10.1002/cti2.1129
bibo:pmid	32419947
has license	cc-by
sha1sum (hex)	48846f9d55798c7f5e8e893bfd54688833532f8e
schema:url	https://doi.org/10.1002/cti2.1129
resource representing a document's title	Dynamic changes in circulating T follicular helper cell composition predict neutralising antibody responses after yellow fever vaccination
has PubMed Central identifier	PMC7221214
has PubMed identifier	32419947
schema:publication	Clin Transl Immunology
resource representing a document's body	covid:48846f9d55798c7f5e8e893bfd54688833532f8e#body_text
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