About: PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target

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About: PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target
Creator	Xiao, Shaobo Cai, Xuepeng Cao, Wanlu Chen, Sunrui Dang, Wen Pan, Qiuwei Su, Junhong Wang, Wenshi Xu, Lei Yin, Yuebang Zhou, Xinying Peppelenbosch, Maikel
Source	Medline; PMC
abstract	Rotavirus infection is a major cause of severe dehydrating diarrhea in infants younger than 5 y old and in particular cases of immunocompromised patients irrespective to the age of the patients. Although vaccines have been developed, antiviral therapy is an important complement that cannot be substituted. Because of the lack of specific approved treatment, it is urgent to facilitate the cascade of further understanding of the infection biology, identification of druggable targets and the final development of effective antiviral therapies. PI3K-Akt-mTOR signaling pathway plays a vital role in regulating the infection course of many viruses. In this study, we have dissected the effects of PI3K-Akt-mTOR signaling pathway on rotavirus infection using both conventional cell culture models and a 3D model of human primary intestinal organoids. We found that PI3K-Akt-mTOR signaling is essential in sustaining rotavirus infection. Thus, blocking the key elements of this pathway, including PI3K, mTOR and 4E-BP1, has resulted in potent anti-rotavirus activity. Importantly, a clinically used mTOR inhibitor, rapamycin, potently inhibited both experimental and patient-derived rotavirus strains. This effect involves 4E-BP1 mediated induction of autophagy, which in turn exerts anti-rotavirus effects. These results revealed new insights on rotavirus-host interactions and provided new avenues for antiviral drug development.
has issue date	2017-06-01(xsd:dateTime)
bibo:doi	10.1080/21505594.2017.1326443
bibo:pmid	28475412
has license	cc-by
sha1sum (hex)	485b745f048cbac696175c1ca05eee8fb46ba026
schema:url	https://doi.org/10.1080/21505594.2017.1326443
resource representing a document's title	PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target
has PubMed Central identifier	PMC5955461
has PubMed identifier	28475412
schema:publication	Virulence
resource representing a document's body	covid:485b745f048cbac696175c1ca05eee8fb46ba026#body_text
is schema:about of	named entity 'ANTIVIRAL' named entity 'cell culture' named entity 'infection' named entity 'strains' named entity 'models' named entity 'This' named entity 'mediated' named entity 'antiviral' named entity 'ROTAVIRUS INFECTION' named entity 'AUTOPHAGY PATHWAY' named entity 'STRAINS' named entity 'IMPORTANT' named entity 'BIOLOGY' named entity 'TARGET' named entity 'MEDIATED' named entity 'PI3K' named entity 'TURN' named entity 'INFANTS' named entity 'LACK' named entity 'INFECTION' named entity 'SPECIFIC' named entity 'CAUSE' named entity 'URGENT' named entity 'VACCINES' named entity 'COMPLEMENT' named entity 'STUDY' named entity 'MODEL OF' named entity 'IDENTIFICATION' named entity 'EFFECTIVE' named entity 'TREATMENT' named entity 'INDUCTION' named entity 'VIRUSES' named entity 'USED' named entity 'PROVIDED' named entity 'ORGANOIDS' named entity 'ESSENTIAL' named entity 'COURSE' named entity 'NEW' named entity 'PATIENT' named entity 'THESE' named entity 'MEDIATED' named entity 'REGULATING' named entity 'THERAPIES' named entity 'DISSECTED' named entity 'AUTOPHAGY' named entity '4E-BP1' named entity 'AXIS' named entity 'MTOR' named entity 'AKT' named entity 'AKT' named entity 'EFFECT' named entity 'YOUNGER' named entity 'PRIMARY' named entity 'FOUND' named entity 'INSIGHTS' named entity 'IS A' named entity 'DERIVED' named entity 'SUSTAINING' named entity 'ROLE' named entity 'HOST' named entity 'ELEMENTS' named entity 'AGE' named entity 'DIARRHEA' named entity 'EXPERIMENTAL' named entity 'PATIENTS' named entity 'UNDERSTANDING' named entity 'HAVE' named entity 'REVEALED' named entity 'EXERTS' named entity 'PI3K'

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