About: Characterization of HCoV-229E fusion core: Implications for structure basis of coronavirus membrane fusion

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About: Characterization of HCoV-229E fusion core: Implications for structure basis of coronavirus membrane fusion Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization of HCoV-229E fusion core: Implications for structure basis of coronavirus membrane fusion
Creator	Wang, Ming Gao, Feng Zhang, Qiangmin Feng, Youjun Liu, Cheng
Source	Elsevier; Medline; PMC
abstract	Abstract Human coronavirus 229E (HCoV-229E), a member of group I coronaviruses, has been identified as one of the major viral agents causing respiratory tract diseases in humans for nearly 40 years. However, the detailed molecular mechanism of the membrane fusion mediated by the spike (S) protein of HCoV-229E remains elusive. Here, we report, for the first time, a rationally designed fusion core of HCoV-229E (HR1-SGGRGG-HR2), which was in vitro produced in GST prokaryotic expression system. Multiple lines of experimental data including gel-filtration, chemical cross-linking, and circular diagram (CD) demonstrated that the HCoV-229E fusion core possesses the typical properties of the trimer of coiled-coil heterodimer (six α-helix bundle). 3D structure modeling presents its most-likely structure, similar to those of coronaviruses that have been well-documented. Collectively, HCoV-229E S protein belongs to the type I fusion protein, which is characterized by the existence of two heptad-repeat regions (HR1 and HR2), furthermore, the available knowledge concerning HCoV-229E fusion core may make it possible to design small molecule or polypeptide drugs targeting the membrane fusion, a crucial step of HCoV-229E infection.
has issue date	2006-07-07(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2006.04.141
bibo:pmid	16714001
has license	els-covid
sha1sum (hex)	47af7e4e43a4ba38e2828e2cd39638a36e87e851
schema:url	https://doi.org/10.1016/j.bbrc.2006.04.141
resource representing a document's title	Characterization of HCoV-229E fusion core: Implications for structure basis of coronavirus membrane fusion
has PubMed Central identifier	PMC7092883
has PubMed identifier	16714001
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:47af7e4e43a4ba38e2828e2cd39638a36e87e851#body_text
is schema:about of	named entity 'polypeptide' named entity 'experimental' named entity 'lines' named entity 'membrane fusion' named entity 'step' named entity 'protein' named entity 'MEMBRANE FUSION' named entity 'STRUCTURE' named entity 'CORE' named entity 'FUSION' named entity 'GST' named entity '3D STRUCTURE' named entity 'REGIONS' named entity 'MAJOR' named entity '28S' named entity 'EXPERIMENTAL DATA' named entity 'KNOWLEDGE' named entity 'DESIGN' named entity 'PROPERTIES' named entity 'HR2' named entity 'HCOV-229E' named entity 'PROKARYOTIC EXPRESSION' named entity 'HUMAN CORONAVIRUS 229E' named entity 'REPEAT' named entity 'HAVE' named entity 'HUMANS' named entity 'MODELING' named entity 'TRIMER' named entity 'ONE OF' named entity 'TIME' named entity 'EXPRESSION SYSTEM' named entity 'CORE' named entity 'DOCUMENTED' named entity 'IN VITRO' named entity 'FUSION PROTEIN' named entity 'BASIS' named entity 'CORONAVIRUS' named entity 'SMALL MOLECULE' named entity 'CHARACTERIZED' named entity 'CHARACTERIZATION' named entity 'STEP' named entity 'PRESENTS' named entity 'YEARS' named entity 'TYPE I' named entity 'HERE' named entity 'INCLUDING' named entity 'RESPIRATORY TRACT DISEASES' named entity 'ITS' named entity 'MEDIATED' named entity 'GEL' named entity 'DETAILED' named entity 'POLYPEPTIDE' named entity 'SIMILAR' named entity 'AVAILABLE' named entity 'LINES' named entity 'A-HELIX' named entity 'FILTRATION' named entity 'POSSESSES' named entity 'FUSION' named entity 'MOLECULAR MECHANISM' named entity 'DIAGRAM' named entity 'INFECTION' named entity 'VIRAL' named entity 'TYPICAL' named entity 'CORONAVIRUSES' named entity 'GROUP I' named entity '229E' named entity 'MAKE' named entity 'BUNDLE' named entity 'STRUCTURE' named entity 'CIRCULAR' named entity 'CAUSING' named entity 'COILED-COIL' named entity 'MEMBRANE FUSION' named entity 'S PROTEIN' named entity 'PROTEIN ' named entity 'POSSIBLE'

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