About: Bacterial co-infection of the respiratory tract in ventilated children with bronchiolitis; a retrospective cohort study

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About: Bacterial co-infection of the respiratory tract in ventilated children with bronchiolitis; a retrospective cohort study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bacterial co-infection of the respiratory tract in ventilated children with bronchiolitis; a retrospective cohort study
Creator	De Jong, Menno Bem, Reinout Calis, Job Van Nijen, Lisa Van Woensel, Job Wiegers, Hanke
Source	Medline; PMC
abstract	BACKGROUND: Viral bronchiolitis is the most common cause of respiratory failure requiring invasive ventilation in young children. Bacterial co-infections may complicate and prolong paediatric intensive care unit (PICU) stay. Data on prevalence, type of pathogens and its association with disease severity are limited though. These data are especially important as bacterial co-infections may be treated using antibiotics and could reduce disease severity and duration of PICU stay. We investigated prevalence of bacterial co-infection and its association with disease severity and PICU stay. METHODS: Retrospective cohort study of the prevalence and type of bacterial co-infections in ventilated children performed in a 14-bed tertiary care PICU in The Netherlands. Children less than 2 years of age admitted between December 2006 and November 2014 with a diagnosis of bronchiolitis and requiring invasive mechanical ventilation were included. Tracheal aspirates (TA) and broncho-alveolar lavages (BAL) were cultured and scored based on the quantity of bacteria colony forming units (CFU) as: co-infection (TA > 10(^5)/BAL > 10(^4) CFU), low bacterial growth (TA < 10(^5)/BAL < 10(^4) CFU), or negative (no growth). Duration of mechanical ventilation and PICU stay were collected using medical records and compared against the presence of co-infection using univariate and multivariate analysis. RESULTS: Of 167 included children 63 (37.7%) had a bacterial co-infection and 67 (40.1%) low bacterial growth. Co-infections occurred within 48 h from intubation in 52 out 63 (82.5%) co-infections. H.influenza (40.0%), S.pneumoniae (27.1%), M.catarrhalis (22.4%), and S.aureus (7.1%) were the most common pathogens. PICU stay and mechanical ventilation lasted longer in children with co-infections than children with negative cultures (9.1 vs 7.7 days, p = 0.04 and 8.1vs 6.5 days, p = 0.02). CONCLUSIONS: In this large study, bacterial co-infections occurred in more than a third of children requiring invasive ventilation for bronchiolitis and were associated with longer PICU stay and mechanical ventilation. These findings support a clinical trial of antibiotics to test whether antibiotics can reduce duration of PICU stay.
has issue date	2019-11-06(xsd:dateTime)
bibo:doi	10.1186/s12879-019-4468-3
bibo:pmid	31694565
has license	cc-by
sha1sum (hex)	478de5b88d15c414509b838ccd2690e9f96ddaa0
schema:url	https://doi.org/10.1186/s12879-019-4468-3
resource representing a document's title	Bacterial co-infection of the respiratory tract in ventilated children with bronchiolitis; a retrospective cohort study
has PubMed Central identifier	PMC6836438
has PubMed identifier	31694565
schema:publication	BMC Infect Dis
resource representing a document's body	covid:478de5b88d15c414509b838ccd2690e9f96ddaa0#body_text
is schema:about of	named entity 'units' named entity 'stay' named entity 'negative' named entity 'PICU' named entity 'colony' named entity 'mechanical ventilation' named entity 'stay' named entity 'PROLONG' named entity 'YEARS' named entity 'BACKGROUND' named entity 'CULTURED' named entity 'CHILDREN' covid:arg/478de5b88d15c414509b838ccd2690e9f96ddaa0 named entity 'CFU' named entity 'Bacterial' named entity 'mechanical ventilation' named entity 'investigated' named entity 'pathogens' named entity 'CFU' named entity 'Duration' named entity 'invasive' named entity 'univariate' named entity 'mechanical ventilation' named entity 'cultures' named entity '2014' named entity 'co-infection' named entity 'S.pneumoniae' named entity 'intubation' named entity 'Retrospective cohort study' named entity 'PICU' named entity 'PICU' named entity 'antibiotics' named entity 'retrospective cohort study' named entity 'diagnosis' named entity 'pulmonary hypertension' named entity 'S. aureus' named entity 'antibiotics' named entity 'co-infection' named entity 'CFU' named entity 'DNA extraction' named entity 'bronchiolitis' named entity 'S. pneumoniae' named entity 'coinfections' named entity 'bacterial pneumonia' named entity 'antibiotics' named entity 'bronchiolitis' named entity 'CRP' named entity 'PICU' named entity 'Viral testing' named entity 'retrospective cohort study' named entity 'viral infections' named entity 'respiratory infections' named entity 'prophylactic antibiotics' named entity 'PICU' named entity 'questionnaire' named entity 'ventilator' named entity 'chest X-ray' named entity 'bronchiolitis' named entity 'invasive ventilation' named entity 'PICU' named entity 'antibiotic' named entity 'bronchiolitis' named entity 'microbiological' named entity 'viral infection' named entity 'demographic data' named entity 'Liverpool' named entity 'viral pathogens' named entity 'S. aureus' named entity 'rhinovirus' named entity 'co-infection' named entity 'Illinois' named entity 'pathogens' named entity 'CFU' named entity 'PICU' named entity 'antibiotic' named entity 'co-infection'

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