About: The Role of the Lung’s Microbiome in the Pathogenesis and Progression of Idiopathic Pulmonary Fibrosis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Role of the Lung’s Microbiome in the Pathogenesis and Progression of Idiopathic Pulmonary Fibrosis
Creator	Balestro, Elisabetta Bernardinello, Nicol Biondini, Davide Cocconcelli, Elisabetta Fracasso, Federico Saetta, Marina Spagnolo, Paolo Tiné, Mariaenrica Molyneaux, Philip Maher, Toby
Source	Medline; PMC
abstract	Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung disease that commonly affects older adults and is associated with the histopathological and/or radiological patterns of usual interstitial pneumonia (UIP). Despite significant advances in our understanding of disease pathobiology and natural history, what causes IPF remains unknown. A potential role for infection in the disease’s pathogenesis and progression or as a trigger of acute exacerbation has long been postulated, but initial studies based on traditional culture methods have yielded inconsistent results. The recent application to IPF of culture-independent techniques for microbiological analysis has revealed previously unappreciated alterations of the lung microbiome, as well as an increased bacterial burden in the bronchoalveolar lavage (BAL) of IPF patients, although correlation does not necessarily entail causation. In addition, the lung microbiome remains only partially characterized and further research should investigate organisms other than bacteria and viruses, including fungi. The clarification of the role of the microbiome in the pathogenesis and progression of IPF may potentially allow its manipulation, providing an opportunity for targeted therapeutic intervention.
has issue date	2019-11-10(xsd:dateTime)
bibo:doi	10.3390/ijms20225618
bibo:pmid	31717661
has license	cc-by
sha1sum (hex)	4716aa61386cb52b7aa834b557cb4e2ac7ec4cad
schema:url	https://doi.org/10.3390/ijms20225618
resource representing a document's title	The Role of the Lung’s Microbiome in the Pathogenesis and Progression of Idiopathic Pulmonary Fibrosis
has PubMed Central identifier	PMC6888416
has PubMed identifier	31717661
schema:publication	Int J Mol Sci
resource representing a document's body	covid:4716aa61386cb52b7aa834b557cb4e2ac7ec4cad#body_text
is schema:about of	named entity 'IDIOPATHIC PULMONARY FIBROSIS' named entity 'ROLE' named entity 'potential' named entity 'IPF' named entity 'usual interstitial pneumonia' named entity 'infection' named entity 'IPF' named entity 'IPF' named entity 'LUNG' named entity 'TRIGGER' named entity 'PATHOGENESIS' named entity 'ADDITION' named entity 'UNKNOWN' named entity 'ALTERATIONS' named entity 'CORRELATION' named entity 'INVESTIGATE' named entity 'OUR' named entity 'ROLE' named entity 'BACTERIA ' named entity 'INITIAL' named entity 'BACTERIAL' named entity 'BURDEN' named entity 'CAUSES' named entity 'CAUSATION' named entity 'BUT' named entity 'CHRONIC' named entity 'INTERSTITIAL LUNG DISEASE' named entity 'MANIPULATION' named entity 'INCREASED' named entity 'RESULTS' named entity 'PARTIALLY' named entity 'RESEARCH' named entity 'REVIEW' named entity 'LONG' named entity 'ACUTE EXACERBATION' named entity 'OPPORTUNITY' named entity 'METHODS' named entity 'APPLICATION' named entity 'REVEALED' named entity 'PATTERNS' named entity 'CULTURE' named entity 'NATURAL HISTORY' named entity 'VIRUSES' named entity 'MICROBIOLOGICAL ANALYSIS' named entity 'BRONCHOALVEOLAR LAVAGE' named entity 'INCLUDING' named entity 'THERAPEUTIC INTERVENTION' named entity 'INFECTION' named entity 'ORGANISMS' named entity 'CONCEPTUALIZATION' named entity 'TARGETED' named entity 'INVESTIGATION' named entity 'DISEASE' named entity 'ACQUISITION' named entity 'DATA CURATION' named entity 'IDIOPATHIC PULMONARY FIBROSIS' named entity 'WRITING' named entity '27S' named entity 'WHAT' named entity 'CLARIFICATION' named entity 'PATHOBIOLOGY' named entity 'IS A' named entity 'HAVE' named entity 'ASSOCIATED WITH' named entity 'PATIENTS' named entity 'IPF' named entity 'LUNG' named entity 'FUNDING' named entity 'EDITING' named entity '27S' named entity 'PATHOGENESIS' named entity 'SIGNIFICANT'

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