About: Identification of the strain-specifically truncated nonstructural protein 10 of porcine reproductive and respiratory syndrome virus in infected cells

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About: Identification of the strain-specifically truncated nonstructural protein 10 of porcine reproductive and respiratory syndrome virus in infected cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of the strain-specifically truncated nonstructural protein 10 of porcine reproductive and respiratory syndrome virus in infected cells
Creator	Dong, Jian-Guo Lei, X Lei, Zhou Xin, Guo Xue-Xia, Wen Yang, Xin-Na Zhang, Zhi-Bang
topic	covid:45fb040cf883438ec58142c276fc3abbbf7dab55#this
Source	Elsevier; Medline; PMC
abstract	Abstract The nonstructural protein 10 (nsp10) of porcine reproductive and respiratory syndrome virus (PRRSV) encodes for helicase which plays a vital role in viral replication. In the present study, a truncated form of nsp10, termed nsp10a, was found in PRRSV-infected cells and the production of nsp10a was strain-specific. Mass spectrometric analysis and deletion mutagenesis indicated that nsp10a may be short of about 70 amino acids in the N terminus of nsp10. Further studies by rescuing recombinant viruses showed that the Glu-69 in nsp10 was the key amino acid for nsp10a production. Finally, we demonstrated that nsp10a exerted little influence on the growth kinetics of PRRSV in vitro.
has issue date	2018-05-31(xsd:dateTime)
bibo:doi	10.1016/s2095-3119(17)61896-3
bibo:pmid	32288956
has license	els-covid
sha1sum (hex)	45fb040cf883438ec58142c276fc3abbbf7dab55
schema:url	https://doi.org/10.1016/s2095-3119%2817%2961896-3
resource representing a document's title	Identification of the strain-specifically truncated nonstructural protein 10 of porcine reproductive and respiratory syndrome virus in infected cells
has PubMed Central identifier	PMC7128467
has PubMed identifier	32288956
schema:publication	Journal of Integrative Agriculture
resource representing a document's body	covid:45fb040cf883438ec58142c276fc3abbbf7dab55#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/45fb040cf883438ec58142c276fc3abbbf7dab55
is schema:about of	named entity 'CELLS' named entity 'reproductive' named entity 'respiratory' named entity 'porcine' named entity 'SHORT' named entity 'STRAIN' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'KEY' named entity 'INDICATED' named entity 'FORM' named entity 'CELLS' named entity 'MASS' named entity 'PLAYS' named entity 'STUDIES' named entity 'INFECTED' named entity 'INFLUENCE' named entity 'HELICASE' named entity 'MAY BE' named entity 'ABOUT' named entity 'ANALYSIS' named entity 'VIRAL REPLICATION' named entity 'STUDY' named entity 'LITTLE' named entity 'VITAL' named entity 'GROWTH KINETICS' named entity 'DEMONSTRATED' named entity 'PRESENT' named entity 'GLU-' named entity 'RECOMBINANT' named entity 'AMINO ACID' named entity 'AMINO ACIDS' named entity 'DELETION MUTAGENESIS' named entity 'PROTEIN ' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'TRUNCATED' named entity 'ROLE' named entity 'PRODUCTION' named entity 'SPECIFIC' named entity 'INFECTED' named entity 'PROTEIN ' named entity 'VIRUSES' named entity 'EXERTED' named entity 'TERMINUS' named entity 'IN VITRO' covid:arg/45fb040cf883438ec58142c276fc3abbbf7dab55 named entity 'encodes' named entity 'vital' named entity 'termed' named entity 'truncated' named entity 'virus' named entity 'amino acid' named entity 'Mass spectrometric analysis' named entity 'recombinant' named entity 'growth kinetics' named entity 'Glu' named entity 'ScienceDirect' named entity 'SDS-PAGE' named entity 'Western blotting' named entity '0.01' named entity 'peptides' named entity 'HEK' named entity 'proteolytic cleavage' named entity 'BSA' named entity 'cell lysates' named entity 'fetal bovine serum' named entity 'amino acid' named entity 'gene' named entity 'transfected' named entity 'peptide sequences' named entity 'viruses' named entity 'Molecular Probes' named entity 'Rockford, IL' named entity 'nsp2'

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