About: SPAAN: a software program for prediction of adhesins and adhesin-like proteins using neural networks

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About: SPAAN: a software program for prediction of adhesins and adhesin-like proteins using neural networks Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SPAAN: a software program for prediction of adhesins and adhesin-like proteins using neural networks
Creator	Jain, Preti Kumar, Kaushal Ramachandran, Srinivasan Sachdeva, Gaurav
Source	Medline; PMC
abstract	Motivation: The adhesion of microbial pathogens to host cells is mediated by adhesins. Experimental methods used for characterizing adhesins are time-consuming and demand large resources. The availability of specialized software can rapidly aid experimenters in simplifying this problem. We have employed 105 compositional properties and artificial neural networks to develop SPAAN, which predicts the probability of a protein being an adhesin (P(ad)). Results: SPAAN had optimal sensitivity of 89% and specificity of 100% on a defined test set and could identify 97.4% of known adhesins at high P(ad) value from a wide range of bacteria. Furthermore, SPAAN facilitated improved annotation of several proteins as adhesins. Novel adhesins were identified in 17 pathogenic organisms causing diseases in humans and plants. In the severe acute respiratory syndrome (SARS) associated human corona virus, the spike glycoprotein and nsps (nsp2, nsp5, nsp6 and nsp7) were identified as having adhesin-like characteristics. These results offer new lead for rapid experimental testing. Availability: SPAAN is freely available through ftp://203.195.151.45 Contact: ramu@igib.res.in
has issue date	2005-02-15(xsd:dateTime)
bibo:doi	10.1093/bioinformatics/bti028
bibo:pmid	15374866
has license	no-cc
sha1sum (hex)	4378c791053e3e123337531d556c6680bac42b32
schema:url	https://doi.org/10.1093/bioinformatics/bti028
resource representing a document's title	SPAAN: a software program for prediction of adhesins and adhesin-like proteins using neural networks
has PubMed Central identifier	PMC7109999
has PubMed identifier	15374866
schema:publication	Bioinformatics
resource representing a document's body	covid:4378c791053e3e123337531d556c6680bac42b32#body_text
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