About: Epidemiology of two human protoparvoviruses, bufavirus and tusavirus

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About: Epidemiology of two human protoparvoviruses, bufavirus and tusavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Epidemiology of two human protoparvoviruses, bufavirus and tusavirus
Creator	Kumar, Arun Söderlund-Venermo, Maria Delwart, Eric Hedman, Klaus Ahmed, Kamruddin Vesikari, Timo Paloniemi, Minna Franssila, Rauli Kuisma, Inka Lithovius, Väinö Väisänen, Elina
Source	Medline; PMC
abstract	Two human parvoviruses were recently discovered by metagenomics in Africa, bufavirus (BuV) in 2012 and tusavirus (TuV) in 2014. These viruses have been studied exclusively by PCR in stool and detected only in patients with diarrhoea, although at low prevalence. Three genotypes of BuV have been identified. We detected, by in-house EIA, BuV1-3 IgG antibodies in 7/228 children (3.1%) and 10/180 adults (5.6%), whereas TuV IgG was found in one child (0.4%). All children and 91% of the adults were Finnish, yet interestingly 3/6 adults of Indian origin were BuV-IgG positive. By competition EIA, no cross-reactivity between the BuVs was detected, indicating that the BuV genotypes represent distinct serotypes. Furthermore, we analysed by BuV qPCR stool and nasal swab samples from 955 children with gastroenteritis, respiratory illness, or both, and found BuV DNA in three stools (0.3%) and for the first time in a nasal swab (0.1%). This is the first study documenting the presence of BuV and TuV antibodies in humans. Although the seroprevalences of both viruses were low in Finland, our results indicate that BuV infections might be widespread in Asia. The BuV-specific humoral immune responses appeared to be strong and long-lasting, pointing to systemic infection in humans.
has issue date	2016-12-14(xsd:dateTime)
bibo:doi	10.1038/srep39267
bibo:pmid	27966636
has license	cc-by
sha1sum (hex)	4305b319111b221a9395cfc71e722cde5e37a61c
schema:url	https://doi.org/10.1038/srep39267
resource representing a document's title	Epidemiology of two human protoparvoviruses, bufavirus and tusavirus
has PubMed Central identifier	PMC5155296
has PubMed identifier	27966636
schema:publication	Sci Rep
resource representing a document's body	covid:4305b319111b221a9395cfc71e722cde5e37a61c#body_text
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