About: Hematological findings in coronavirus disease 2019: indications of progression of disease

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hematological findings in coronavirus disease 2019: indications of progression of disease
Creator	Liu, Xiaoqing He, Guangsheng Zhang, Run
Source	Medline; PMC
abstract	Coronavirus disease 2019 (COVID-19) is a new human infectious disease. The etiology for this outbreak is a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thus far, related research on COVID-19 is still in preliminary stage. This paper summarized the latest outcomes of corresponding study from Chinese centers and clarified the hematopoietic abnormality caused by SARS-CoV-2 and potential mechanism. Lymphopenia was common in the early stage after the onset of COVID-19. A significant decrease was observed in peripheral CD4+ and CD8+ T lymphocytes. As the illness progressed, neutrophilia emerged in several cases, and patients with severe critical pulmonary conditions showed higher neutrophils than common type. Thrombocytopenia was resulting from the consumption and/or the reduced production of platelets in damaged lungs. Anemia was not observed notably, but the decrease in hemoglobin was frequent. The activation of monocyte-macrophage system aggravates the immune damage of lung and other tissues, which leads to the increase of D-dimer, prothrombin time, and platelet consumption.
has issue date	2020-06-03(xsd:dateTime)
bibo:doi	10.1007/s00277-020-04103-5
bibo:pmid	32495027
has license	no-cc
sha1sum (hex)	42b852fec5e54b38097b41a4135a39602df90afe
schema:url	https://doi.org/10.1007/s00277-020-04103-5
resource representing a document's title	Hematological findings in coronavirus disease 2019: indications of progression of disease
has PubMed Central identifier	PMC7266734
has PubMed identifier	32495027
schema:publication	Ann Hematol
resource representing a document's body	covid:42b852fec5e54b38097b41a4135a39602df90afe#body_text
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