About: Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice

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About: Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice
Creator	Almazan, Guillermina Fragoso, Gabriela Jacomy, Hélène Talbot, Pierre Mushynski, Walter
source	Elsevier; Medline; PMC
abstract	Abstract The notion that an infectious respiratory pathogen can damage the central nervous system (CNS) and lead to neurological disease was tested using a human respiratory coronavirus, the OC43 strain of human coronavirus (HCoV-OC43). First, primary cell cultures were used to determine the susceptibility of each type of neural cells to virus infection. Neurons were the target cells, undergoing degeneration during infection, in part due to apoptosis. Second, neuropathogenicity was investigated in susceptible mice. Intracerebral inoculation of HCoV-OC43 into BALB/c mice led to an acute encephalitis with neuronal cell death by necrosis and apoptosis. Infectious virus was apparently cleared from surviving animals, whereas viral RNA persisted for several months. Some of the animals surviving to acute encephalitis presented an abnormal limb clasping reflex and a decrease in motor activity starting several months post-infection. These results suggest that viral persistence could be associated with an increased neuronal degeneration leading to neuropathology and motor deficits in susceptible individuals.
has issue date	2006-06-05(xsd:dateTime)
bibo:doi	10.1016/j.virol.2006.01.049
bibo:pmid	16527322
has license	els-covid
sha1sum (hex)	427a3e2947a3a75b52e4fdfef9a1832965e5dd82
schema:url	https://doi.org/10.1016/j.virol.2006.01.049
resource representing a document's title	Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice
has PubMed Central identifier	PMC7111850
has PubMed identifier	16527322
schema:publication	Virology
resource representing a document's body	covid:427a3e2947a3a75b52e4fdfef9a1832965e5dd82#body_text
is schema:about of	named entity 'strain' named entity 'viral' named entity 'target cells' named entity 'HCoV-OC43' named entity 'disabilities' named entity 'infection' named entity 'BALB' named entity 'ASSOCIATED WITH' named entity 'POST' named entity 'BALB' named entity 'LEADING' named entity 'ANIMALS' named entity 'DECREASE' named entity 'PRESENTED' named entity 'DUE TO' named entity 'ABNORMAL LIMB' named entity 'VIRAL PERSISTENCE' named entity 'DETERMINE' named entity 'APOPTOSIS' named entity 'VIRUS' named entity 'SUSCEPTIBILITY' named entity 'NOTION' named entity 'USED' named entity 'TESTED' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'INVESTIGATED' named entity 'CHRONIC ENCEPHALITIS' named entity 'STRAIN' named entity 'USING' named entity 'HUMAN' named entity 'INTRACEREBRAL' named entity 'INDIVIDUALS' named entity 'INCREASED' named entity 'MICE' named entity 'DISABILITIES' named entity 'OF EACH' named entity 'NEUROLOGICAL DISEASE' named entity 'MONTHS' named entity 'REFLEX' named entity 'APPARENTLY' named entity 'NECROSIS' named entity 'INFECTION' named entity 'CORONAVIRUS' named entity 'TYPE' named entity 'OC43' named entity 'NEURONAL CELL DEATH' named entity 'STARTING' named entity 'THESE' named entity 'ACUTE ENCEPHALITIS' named entity 'MOTOR DEFICITS' named entity 'TARGET CELLS' named entity 'HUMAN CORONAVIRUS OC43' named entity 'SUGGEST' named entity 'COULD BE' named entity 'RESULTS' named entity 'VIRAL RNA' named entity 'CLEARED' named entity 'SUSCEPTIBLE' named entity 'HUMAN CORONAVIRUS' named entity 'SECOND' named entity 'LEADING' named entity 'MOTOR ACTIVITY' named entity 'NEUROPATHOLOGY' named entity 'PRIMARY CELL CULTURES' named entity 'INFECTIOUS' named entity 'HCOV-OC43' named entity 'INOCULATION' named entity 'CELLS' named entity 'INFECTION' named entity 'NEURAL' named entity 'DEGENERATION' named entity 'LEAD' named entity 'VIRUS INFECTION' named entity 'LIMB CLASPING' named entity 'MICE' named entity 'NEURONS' named entity 'RESPIRATORY'

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