About: Performance of a multiplex PCR pneumonia panel for the identification of respiratory pathogens and the main determinants of resistance from the lower respiratory tract specimens of adult patients in intensive care units

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About: Performance of a multiplex PCR pneumonia panel for the identification of respiratory pathogens and the main determinants of resistance from the lower respiratory tract specimens of adult patients in intensive care units Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Performance of a multiplex PCR pneumonia panel for the identification of respiratory pathogens and the main determinants of resistance from the lower respiratory tract specimens of adult patients in intensive care units
Creator	Hsueh, Po-Ren Pan, Sung-Ching Chien, Jung-Yien Lee, Tai-Fen Ruan, Sheng-Yuan Lee, Sze
Source	Elsevier; Medline; PMC
abstract	Abstract Background Timely diagnostic investigation to establish the microbial etiology of pneumonia is essential to ensure the administration of effective antibiotic therapy to individual patients. Methods We evaluated a multiplex PCR assay panel, the FilmArray® pneumonia panel (FilmArray PP, BioFire Diagnostics), for detection of 35 respiratory pathogens and resistance determinants and compared the performance of the standard-of-care test in intensive care unit patients with lower respiratory tract infections. Results Among the 59 endotracheal aspirates and bronchoalveolar lavage specimens obtained from 51 adult patients, FilmArray PP was effective in detecting respiratory bacterial pathogens with an overall positive percent agreement of 90% (95% confidence interval [CI], 73.5–97.9%) and negative percent agreement of 97.4% (95% CI, 96.0–98.4%). FilmArray PP semi-quantitative reporting demonstrated a concordance rate of 53.6% for the culture-positive specimens and 86.3% for the culture-negative specimens. FilmArray PP detected 16 viral targets, whereas the conventional viral isolation failed, except influenza A, which showed 100% concordance with PCR. Coinfections were detected in 42.3% of the specimens. Substantial discrepancies were observed in identifying antimicrobial resistance gene targets and in the susceptibility testing. However, FilmArray PP may still be useful at the early stage of pneumonia before culture and susceptibility test reports are available. Consequently, the results of FilmArray PP might alter the antibiotic prescription in 40.7% of the patients. Conclusions FilmArray PP offers a rapid and sensitive diagnostic method for lower respiratory tract infections. However, clinical correlation is advised to determine its significance in interpreting multiple pathogens and detection of genes involved in antimicrobial resistance.
has issue date	2019-12-31(xsd:dateTime)
bibo:doi	10.1016/j.jmii.2019.10.009
bibo:pmid	31806539
has license	els-covid
sha1sum (hex)	426d6775eb996f739d136d5c479e4b723b2a490b
schema:url	https://doi.org/10.1016/j.jmii.2019.10.009
resource representing a document's title	Performance of a multiplex PCR pneumonia panel for the identification of respiratory pathogens and the main determinants of resistance from the lower respiratory tract specimens of adult patients in intensive care units
has PubMed Central identifier	PMC7185395
has PubMed identifier	31806539
schema:publication	Journal of Microbiology, Immunology and Infection
resource representing a document's body	covid:426d6775eb996f739d136d5c479e4b723b2a490b#body_text
is schema:about of	named entity 'patients' named entity 'effective' named entity 'etiology' named entity 'concordance' named entity 'panel' named entity 'performance' named entity 'detecting' named entity 'ensure' named entity 'specimens' named entity 'targets' named entity 'determine' named entity 'ORIGINAL' named entity 'CONFIDENCE INTERVAL' named entity 'DIAGNOSTIC METHOD' named entity 'EFFECTIVE' named entity 'POSITIVE' named entity 'DIAGNOSTIC' named entity 'RAPID' named entity 'INFECTION' named entity 'INTENSIVE CARE UNIT' named entity 'PCR' named entity 'AVAILABLE' named entity 'TIMELY' named entity 'ETIOLOGY' named entity 'CARE' named entity 'ENDOTRACHEAL' named entity 'PNEUMONIA' named entity 'MULTIPLEX PCR' named entity 'GENES' named entity 'CULTURE' named entity 'PERFORMANCE' named entity 'REPORTING' named entity 'NEGATIVE' named entity 'SUSCEPTIBILITY TEST' named entity 'RESPIRATORY' named entity 'REPORTS' named entity 'DISCREPANCIES' named entity 'CONCLUSIONS' named entity 'OBSERVED' covid:arg/426d6775eb996f739d136d5c479e4b723b2a490b named entity 'PERCENT' named entity 'SUSCEPTIBILITY TESTING' named entity 'BACTERIAL PATHOGENS' named entity 'ESTABLISH' named entity 'DETECTED' named entity '100%' named entity 'PRESCRIPTION' named entity 'ADMINISTRATION' named entity 'JOURNAL ' named entity 'OBTAINED' named entity 'USEFUL' named entity 'PATIENTS' named entity 'DEMONSTRATED' named entity 'INVOLVED' named entity 'ITS' named entity 'COMPARED' named entity 'RATE' named entity 'METHODS' named entity 'EVALUATED' named entity 'MICROBIAL' named entity 'CONCORDANCE' named entity 'ANTIBIOTIC THERAPY' named entity 'AGREEMENT' named entity 'SENSITIVE' named entity 'PANEL' named entity 'MICROBIOLOGY' named entity 'RESISTANCE' named entity 'EARLY STAGE' named entity 'DETECTION' named entity 'ANTIBIOTIC' named entity 'RESPIRATORY PATHOGENS' named entity 'ALTER' named entity 'VIRAL' named entity 'LOWER RESPIRATORY TRACT INFECTIONS' named entity 'PCR ASSAY' named entity 'BACKGROUND'

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