About: Differential Immune Responses to Hemorrhagic Fever-Causing Arenaviruses

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Differential Immune Responses to Hemorrhagic Fever-Causing Arenaviruses
Creator	Paessler, Slobodan Huang, Cheng Mantlo, Emily
Source	Medline; PMC
abstract	The family Arenaviridae contains several pathogens of major clinical importance. The Old World (OW) arenavirus Lassa virus is endemic in West Africa and is estimated to cause up to 300,000 infections each year. The New World (NW) arenaviruses Junín and Machupo periodically cause hemorrhagic fever outbreaks in South America. While these arenaviruses are highly pathogenic in humans, recent evidence indicates that pathogenic OW and NW arenaviruses interact with the host immune system differently, which may have differential impacts on viral pathogenesis. Severe Lassa fever cases are characterized by profound immunosuppression. In contrast, pathogenic NW arenavirus infections are accompanied by elevated levels of Type I interferon and pro-inflammatory cytokines. This review aims to summarize recent findings about interactions of these pathogenic arenaviruses with the innate immune machinery and the subsequent effects on adaptive immunity, which may inform the development of vaccines and therapeutics against arenavirus infections.
has issue date	2019-10-02(xsd:dateTime)
bibo:doi	10.3390/vaccines7040138
bibo:pmid	31581720
has license	cc-by
sha1sum (hex)	424ea1927a270902bd78e27db83dd9411b4ea9a6
schema:url	https://doi.org/10.3390/vaccines7040138
resource representing a document's title	Differential Immune Responses to Hemorrhagic Fever-Causing Arenaviruses
has PubMed Central identifier	PMC6963578
has PubMed identifier	31581720
schema:publication	Vaccines (Basel)
resource representing a document's body	covid:424ea1927a270902bd78e27db83dd9411b4ea9a6#body_text
is schema:about of	named entity 'IMMUNE RESPONSES' named entity 'differential' named entity 'highly' named entity 'interactions' named entity 'PATHOGENIC' named entity 'IMMUNE SYSTEM' named entity 'EFFECTS' named entity 'ARENAVIRUS INFECTIONS' named entity 'WEST AFRICA' named entity 'ARENAVIRUS' named entity 'JUN' named entity 'REVIEW' named entity 'HOST' named entity 'OUTBREAKS' named entity 'INTERACT' named entity 'AIMS' named entity 'CHARACTERIZED' named entity 'LASSA FEVER' named entity 'ADN' named entity 'VACCINES' named entity 'DIFFERENTIAL' named entity 'HEMORRHAGIC FEVER' named entity '300' named entity 'IMMUNE' named entity 'ADAPTIVE IMMUNITY' named entity 'WORLD' named entity 'CAUSE' named entity 'EVIDENCE' named entity 'FINDINGS ABOUT' named entity 'INTERACTIONS' named entity 'CYTOKINES' named entity 'THESE' named entity 'ESTIMATED' named entity 'INFECTIONS' named entity 'OLD' named entity 'INFORM' named entity 'PRO-' named entity 'IMPACTS' named entity 'HIGHLY' named entity 'CONTRAST' named entity 'SUBSEQUENT' named entity 'ELEVATED' named entity 'DIFFERENTIAL' named entity 'SOUTH AMERICA' named entity 'MACHINERY' named entity 'UP TO' named entity 'SEVERE' named entity 'PATHOGENS' named entity 'LASSA VIRUS' named entity 'DEVELOPMENT' named entity 'MAY HAVE' named entity 'ENDEMIC' named entity 'ARENAVIRUSES' named entity 'FAMILY' named entity 'CONTAINS' named entity 'PROFOUND' named entity 'INTERFERON ' named entity 'IMMUNOSUPPRESSION' named entity 'ARENAVIRIDAE' named entity 'CAUSING' named entity 'LEVELS' named entity 'HUMANS' named entity 'CASES' named entity 'PERIODICALLY' named entity 'THERAPEUTICS' named entity 'RECENT' named entity 'INFLAMMATORY' named entity 'VIRAL PATHOGENESIS' named entity 'TYPE I INTERFERON' named entity 'CLINICAL' named entity 'NEW' named entity 'HEMORRHAGIC FEVER' named entity 'ARENAVIRUSES' named entity 'MAJOR' named entity 'YEAR' named entity 'contrast' named entity 'South America' named entity 'Lassa virus' named entity 'subsequent'

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