About: Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors

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About: Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors
Creator	Bosch, Berend-Jan Li, Wentao Veesler, David Walls, Alexandra Park, Young-Jun Dimaio, Frank Tortorici, M Sauer, Maximillian Wang, Zhaoqian
Source	Medline; PMC
abstract	The Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe and often lethal respiratory illness in humans, and no vaccines or specific treatments are available. Infections are initiated via binding of the MERS-CoV spike (S) glycoprotein to sialosides and dipeptidyl-peptidase 4 (the attachment and entry receptors, respectively). To understand MERS-CoV engagement of sialylated receptors, we determined the cryo-EM structures of S in complex with 5-N-acetyl neuraminic acid, 5-N-glycolyl neuraminic acid, sialyl-Lewis(X), α2,3-sialyl-N-acetyl-lactosamine and α2,6-sialyl-N-acetyl-lactosamine at 2.7–3.0 Å resolution. We show that recognition occurs via a conserved groove that is essential for MERS-CoV S-mediated attachment to sialosides and entry into human airway epithelial cells. Our data illuminate MERS-CoV S sialoside specificity and suggest that selectivity for α2,3-linked over α2,6-linked receptors results from enhanced interactions with the former class of oligosaccharides. This study provides a structural framework explaining MERS-CoV attachment to sialoside receptors and identifies a site of potential vulnerability to inhibitors of viral entry.
has issue date	2019-12-02(xsd:dateTime)
bibo:doi	10.1038/s41594-019-0334-7
bibo:pmid	31792450
has license	no-cc
sha1sum (hex)	3ffe77c5024f9b8f74349a8905ef8929f5b48742
schema:url	https://doi.org/10.1038/s41594-019-0334-7
resource representing a document's title	Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors
has PubMed Central identifier	PMC7097669
has PubMed identifier	31792450
schema:publication	Nat Struct Mol Biol
resource representing a document's body	covid:3ffe77c5024f9b8f74349a8905ef8929f5b48742#body_text
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