About: Development and Clinical Application of Phosphorus-Containing Drugs

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Development and Clinical Application of Phosphorus-Containing Drugs
Creator	Shi, Enxue Tang, Wenjun Yang, He Yu, Hanxiao
Source	Elsevier; PMC
abstract	Phosphorus-containing drugs belong to an important class of therapeutic agents and are widely applied in daily clinical practices. Structurally, the phosphorus-containing drugs can be classified into phosphotriesters, phosphonates, phosphinates, phosphine oxides, phosphoric amides, bisphosphonates, phosphoric anhydrides, and others; functionally, they are often designed as prodrugs with improved selectivity and bioavailability, reduced side effects and toxicity, or biomolecule analogues with endogenous materials and antagonistic endoenzyme supplements. This review summarized the phosphorus-containing drugs currently on the market as well as a few promising molecules at clinical studies, with particular emphasis on their structural features, biological mechanism, and indications.
has issue date	2020-08-25(xsd:dateTime)
bibo:doi	10.1016/j.medidd.2020.100063
has license	no-cc
sha1sum (hex)	3fc18cc0fe227f35556c14ae2b2da6b6b945ef1d
schema:url	https://doi.org/10.1016/j.medidd.2020.100063
resource representing a document's title	Development and Clinical Application of Phosphorus-Containing Drugs
has PubMed Central identifier	PMC7445155
schema:publication	Med Drug Discov
resource representing a document's body	covid:3fc18cc0fe227f35556c14ae2b2da6b6b945ef1d#body_text
is schema:about of	named entity 'head louse' named entity 'glycerol' named entity 'phosphorus' named entity 'tenofovir disoproxil' named entity 'ACE' named entity 'prednisolone' named entity 'Synkayvite' named entity 'tertiary alcohols' named entity 'postmenopause' named entity 'metabolism' named entity 'dichlorvos' named entity 'bisphosphonates' named entity 'miotic' named entity 'serine' named entity 'alkylating agents' named entity 'skin irritation' named entity 'alcohols' named entity 'adapalene' named entity 'menadiol' named entity 'prostatic cancer' named entity 'antiviral drugs' named entity 'organism' named entity 'HIV infection' named entity 'FAD' named entity 'hepatitis' named entity 'oral bioavailability' named entity 'sodium' named entity 'fosamprenavir' named entity 'cholinesterase' named entity 'foscarnet' named entity 'Figure 17' named entity 'neridronic acid' named entity 'RNA polymerase' named entity 'nonsteroidal anti-inflammatory' named entity 'nucleotide analog' named entity 'bacterial infections' named entity 'Didronel' named entity 'peripheral vascular disease' named entity 'phosphoryl' named entity 'metabolite' named entity 'bone resorption' named entity 'alkylating agent' named entity 'drug molecules' named entity 'triazole antifungal' named entity 'toxicity' named entity 'biosyntheses' named entity 'phosphate' named entity 'intramuscular' named entity 'platelet' named entity 'vidarabine' named entity 'aqueous' named entity 'chemical stability' named entity 'hydrate' named entity 'ATP' named entity 'bacterial cell wall' named entity 'phosphite' named entity 'clindamycin phosphate' named entity 'emtricitabine' named entity 'prodrugs' named entity 'propofol' named entity 'fosazepam' named entity 'enzyme' named entity 'triclofos' named entity 'Ridaura' named entity 'nitric oxide' named entity 'pathogens' named entity 'fosinopril' named entity 'BBB' named entity 'aqueous' named entity 'covalently binding' named entity 'Fosfomycin' named entity 'serotonin' named entity 'reverse transcriptase' named entity 'Triapten' named entity 'cardiovascular drugs' named entity 'hydroxyl' named entity 'Telzir' named entity 'coenzyme' named entity 'vitamin B12' named entity 'ATP'

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