About: The cytoplasmic tail of hantavirus Gn glycoprotein interacts with RNA

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The cytoplasmic tail of hantavirus Gn glycoprotein interacts with RNA
Creator	Vaheri, Antti Wang, Hao Hepojoki, Jussi Lankinen, Hilkka Strandin, Tomas
Source	Elsevier; Medline; PMC
abstract	Abstract We recently characterized the interaction between the intraviral domains of envelope glycoproteins (Gn and Gc) and ribonucleoprotein (RNP) of Puumala and Tula hantaviruses (genus Hantavirus, family Bunyaviridae). Herein we report a direct interaction between spike-forming glycoprotein and nucleic acid. We show that the envelope glycoprotein Gn of hantaviruses binds genomic RNA through its cytoplasmic tail (CT). The nucleic acid binding of Gn-CT is unspecific, as demonstrated by interactions with unrelated RNA and with single-stranded DNA. Peptide scan and protein deletions of Gn-CT mapped the nucleic acid binding to regions that overlap with the previously characterized N protein binding sites and demonstrated the carboxyl-terminal part of Gn-CT to be the most potent nucleic acid-binding site. We conclude that recognition of the RNP complex by the Gn-CT could be mediated by interactions with both genomic RNA and the N protein. This would provide the required selectivity for the genome packaging of hantaviruses.
has issue date	2011-09-15(xsd:dateTime)
bibo:doi	10.1016/j.virol.2011.06.030
bibo:pmid	21807393
has license	els-covid
sha1sum (hex)	3efc5f0df74973560cd4174c7d681291fe085122
schema:url	https://doi.org/10.1016/j.virol.2011.06.030
resource representing a document's title	The cytoplasmic tail of hantavirus Gn glycoprotein interacts with RNA
has PubMed Central identifier	PMC7172371
has PubMed identifier	21807393
schema:publication	Virology
resource representing a document's body	covid:3efc5f0df74973560cd4174c7d681291fe085122#body_text
is schema:about of	named entity 'glycoprotein' named entity 'cytoplasmic' covid:arg/3efc5f0df74973560cd4174c7d681291fe085122 named entity 'Bunyaviridae' named entity 'The' named entity 'Puumala' named entity 'glycoproteins' named entity 'glycoprotein' named entity 'cytoplasmic tail' named entity 'protein' named entity '37°C' named entity 'signal sequence' named entity 'co-immunoprecipitation' named entity 'nucleic acids' named entity 'avidin' named entity 'hemagglutinin' named entity 'immunoprecipitation' named entity 'nucleocapsid' named entity 'RNA' named entity 'PUUV' named entity 'nucleic acids' named entity 'RNA' named entity 'nairovirus' named entity 'RNA' named entity 'assay' named entity 'fetal calf serum' named entity 'CTs' named entity 'metabolically' named entity 'nucleic acid' named entity 'nuclear localization signal' named entity 'PUUV' named entity 'protein' named entity 'cell culture medium' named entity 'glycoproteins' named entity 'peptide' named entity 'antisera' named entity 'CCHFV' named entity 'single-stranded' named entity 'SDS-PAGE' named entity 'single-stranded' named entity 'w/v' named entity 'PUUV' named entity 'hantavirus' named entity 'lysates' named entity 'hantaviruses' named entity 'protein' named entity 'RNase' named entity 'PAb' named entity 'genome' named entity 'antigens' named entity 'virion' named entity 'avidin' named entity 'Laemmli' named entity 'PAb' named entity 'RNA' named entity 'RNA' named entity 'PUUV' named entity 'methionine' named entity 'virion' named entity 'RNA' named entity 'glycoproteins' named entity 'PUUV' named entity 'matrix protein' named entity 'SDS-PAGE' named entity 'negative control' named entity 'PUUV' named entity 'viral envelope' named entity 'hantaviruses' named entity 'C-terminal' named entity 'genus' named entity 'antibodies' named entity 'MAb' named entity 'counts per minute' named entity 'C-terminal' named entity 'nucleic acid' named entity 'gene expression' named entity 'C-terminal'

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