About: Is respiratory viral infection really an important trigger of asthma exacerbations in children?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Is respiratory viral infection really an important trigger of asthma exacerbations in children?
Creator	Lau, Yu-Lung Chan, & Kwok-Hung Chan, K.-H Chiu, S.-S Chiu, Susan Lau, Y.-L Lee, S.-L Lee, So-Lun Malik, Joseph Malik, P Peiris, & Shui-Seng, & Wong, H.-S Wong, Wilfred
Source	Medline; PMC
abstract	We performed a prospective cohort study from September 2003 to December 2004 to delineate attributing the effect of different respiratory viral infections including newly discovered ones to asthma exacerbations in children in Hong Kong. One hundred and fourteen children aged 6–14 years with chronic stable asthma and on regular inhaled steroid were monitored for respiratory symptoms over a full calendar year from recruitment. They would attend the study clinic if peak expiratory flow rate decreased to below 80% of their baselines, if they met a predefined symptom score, or if parents subjectively felt them developing a cold. Virological diagnosis using virus culture, antigen detection, and polymerase chain reaction methods on nasal swab specimens would be attempted for all these visits irrespective of triggers. Physician diagnosed outcome of each episode was documented. Three hundred and five episodes of respiratory illnesses were captured in the cohort. Nasal specimens were available in 166 episodes, 92 of which were diagnosed as asthma exacerbations, and 74 non-asthma related episodes. Respiratory viruses were detected in 61 of 166 episodes (36.7%). There was no significant difference in virus detection rate between asthma exacerbations (32 out of 97 episodes, 34.8%) and non-asthma respiratory illnesses (29 out of 79 episodes, 39.2%). Although newly discovered respiratory viruses were identified in these episodes, rhinovirus was the commonest organism associated with both asthma exacerbations and non-asthma related episodes. Plausible explanations for much lower virus detection rate than previously reported include improved personal hygiene and precautionary measures taken during respiratory tract infections in the immediate post-severe acute respiratory syndrome period together with a significant contribution of other adverse factors like environmental air pollution. We conclude that not all viral infections in children with asthma lead to an asthma exacerbation and the attributing effect of different triggers of asthma exacerbations in children vary across different time periods and across different localities.
has issue date	2011-03-30(xsd:dateTime)
bibo:doi	10.1007/s00431-011-1446-1
bibo:pmid	21448631
has license	cc-by-nc
sha1sum (hex)	3ee377ece8b8a1fb6a4468d39d410f0f33042051
schema:url	https://doi.org/10.1007/s00431-011-1446-1
resource representing a document's title	Is respiratory viral infection really an important trigger of asthma exacerbations in children?
has PubMed Central identifier	PMC3175036
has PubMed identifier	21448631
schema:publication	Eur J Pediatr
resource representing a document's body	covid:3ee377ece8b8a1fb6a4468d39d410f0f33042051#body_text
is schema:about of	named entity 'ASTHMA EXACERBATIONS' named entity 'RESPIRATORY' named entity 'COLD' named entity 'PERSONAL HYGIENE' named entity 'DELINEATE' named entity '166' named entity 'STUDY' named entity 'ENVIRONMENTAL' named entity 'THEIR' named entity 'FELT' named entity 'CONCLUDE' named entity 'EPISODES' named entity 'VISITS' named entity 'REPORTED' named entity 'MEASURES' named entity 'THREE HUNDRED AND FIVE' named entity 'RECRUITMENT' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'POST' named entity '80%' named entity 'COHORT' named entity 'BASELINES' named entity 'STABLE' named entity 'RESPIRATORY VIRUSES' named entity 'AGED' named entity 'RATE' named entity 'INCLUDE' named entity 'study' named entity 'episodes' named entity 'episodes' named entity 'Although' named entity 'identified' named entity 'symptoms' named entity 'Hong Kong' named entity 'respiratory' named entity 'air pollution' named entity 'respiratory illnesses' named entity 'cohort' named entity 'rhinovirus' named entity 'Respiratory syncytial virus' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' covid:arg/3ee377ece8b8a1fb6a4468d39d410f0f33042051 named entity 'IMPORTANT' named entity 'CHILDREN' named entity 'MONITORED' named entity 'TRIGGER' named entity 'ASTHMA EXACERBATIONS' named entity 'DIFFERENT' named entity 'TRIGGERS' named entity 'RHINOVIRUS' named entity 'ONE HUNDRED AND FOURTEEN' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'IMMEDIATE' named entity 'LIKE' named entity 'AVAILABLE' named entity 'DIFFERENCE' named entity 'SPECIMENS' named entity 'HONG KONG' named entity 'VIRUS DETECTION' named entity 'ASSOCIATED WITH' named entity 'AIR POLLUTION' named entity 'CLINIC' named entity 'PCR' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'RESPIRATORY VIRAL INFECTION' named entity 'SARS' named entity 'CHILDREN' named entity 'PARENTS'

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