About: Polypeptide N-acetylgalactosaminyltransferase 2 regulates cellular metastasis-associated behavior in gastric cancer

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About: Polypeptide N-acetylgalactosaminyltransferase 2 regulates cellular metastasis-associated behavior in gastric cancer Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Polypeptide N-acetylgalactosaminyltransferase 2 regulates cellular metastasis-associated behavior in gastric cancer
Creator	Cheng, Zhihong Hua, Dong Jiang, Zhi Shen, L Wu, Shiliang Xu, Lan Yue, Aihuan Zhou, Yinghui Zou, Shitao
topic	covid:3d2fae37d61a2e45cf0dff9bc0abee361bbf9a8d#this
Source	PMC
abstract	Aberrant glycosylation of cell surface glycoprotein due to specific alterations of glycosyltransferase activity is usually associated with invasion and metastasis of cancer, particularly of gastric carcinomas. Polypeptide N-acetylgalactosaminyltransferase 2 (ppGalNAc-T2), which catalyzes initiation of mucin-type O-glycosylation, is also involved in tumor migration and invasion. However, a comprehensive understanding of how ppGalNAc-T2 correlates with the metastasic potential of human gastric cancer is not currently available. In the present study, ppGalNAc-T2 was detected in a variety of human poorly differentiated tumor cells, and expression appeared to be higher in SGC7901 gastric cancer cells. In addition, we investigated the potential effects of ppGalNAc-T2 on growth and metastasis-associated behavior in SGC7901 cells after stable transfection with ppGalNAc-T2 sense and antisense vectors. We found that cell proliferation, adhesion and invasion were decreased in ppGalNAc-T2 overexpressed cells but increased in ppGalNAc-T2 downregulated cells. Therefore, we attempted to clarify the mechanisms underlying the anti-metastatic activities of ppGalNAc-T2. Further investigation indicated that overexpression of ppGalNAc-T2 is involved in the inhibition of matrix metalloproteinase (MMP)-2 expression at both the protein and mRNA levels, which may be associated with ppGalNAc-T2 suppressing the expression of transforming growth factor (TGF)-β1. However, it did not exhibit any apparent correlation with MMP-14 expression levels. Our data show the effect of ppGalNAc-T2 on proliferation, adhesion or invasion of SGC7901 gastric cancer cells, suggesting that ppGalNAc-T2 may exert anti-proliferative and anti-metastatic activity through the decrease of MMP-2 and TGF-β1. These results indicate that ppGalNAc-T2 may be used as a novel therapeutic target for human gastric cancer treatment.
has issue date	2012-09-18(xsd:dateTime)
bibo:doi	10.3892/ijmm.2012.1130
bibo:pmid	22992780
has license	cc-by
sha1sum (hex)	3d2fae37d61a2e45cf0dff9bc0abee361bbf9a8d
schema:url	https://doi.org/10.3892/ijmm.2012.1130
resource representing a document's title	Polypeptide N-acetylgalactosaminyltransferase 2 regulates cellular metastasis-associated behavior in gastric cancer
has PubMed Central identifier	PMC4042861
has PubMed identifier	22992780
schema:publication	Int J Mol Med
resource representing a document's body	covid:3d2fae37d61a2e45cf0dff9bc0abee361bbf9a8d#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/3d2fae37d61a2e45cf0dff9bc0abee361bbf9a8d
is schema:about of	named entity 'initiation' named entity 'matrix metalloproteinase' named entity 'Therefore' named entity 'clarify' named entity 'gastric cancer' named entity 'Our' named entity 'levels' named entity 'CELL SURFACE' named entity 'STUDY' named entity 'MMP-2' named entity 'DATA' named entity 'SUPPRESSING' named entity 'BUT' named entity 'MUCIN' named entity 'COMPREHENSIVE' named entity 'MMP-14' named entity 'INITIATION' named entity 'ACTIVITIES' named entity 'RESULTS' named entity 'ADDITION' named entity 'ANTISENSE' named entity 'CELLS' named entity 'AVAILABLE' named entity 'EXPRESSION' named entity 'THESE' named entity 'GASTRIC' named entity 'STABLE TRANSFECTION' named entity 'PRESENT' named entity 'VARIETY' named entity 'ALTERATIONS' named entity 'SENSE' named entity 'DUE TO' named entity 'UNDERSTANDING' named entity 'ADHESION' named entity 'PROLIFERATIVE' named entity 'HIGHER' named entity 'THERAPEUTIC TARGET' named entity 'USUALLY' named entity 'TRANSFORMING GROWTH FACTOR' named entity 'MAY BE' named entity 'TYPE' named entity 'TUMOR CELLS' named entity 'GROWTH' named entity 'CLARIFY' named entity 'ATTEMPTED' named entity 'EFFECTS' named entity 'INHIBITION' named entity 'EFFECT' named entity 'ABERRANT' named entity 'MRNA' named entity 'HOW' named entity 'TUMOR' named entity 'PROTEIN ' named entity 'SPECIFIC' named entity 'EXHIBIT' covid:arg/3d2fae37d61a2e45cf0dff9bc0abee361bbf9a8d named entity 'METASTATIC' named entity 'VECTORS' named entity 'EXERT' named entity 'MIGRATION' named entity 'GASTRIC CANCER' named entity 'BEHAVIOR' named entity 'ASSOCIATED' named entity 'CELLULAR' named entity 'METASTASIS' named entity 'CURRENTLY' named entity 'OUR' named entity 'CELL PROLIFERATION' named entity 'CANCER TREATMENT' named entity 'CORRELATION' named entity 'UNDERLYING'

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