About: West Nile virus capsid protein induces p53‐mediated apoptosis via the sequestration of HDM2 to the nucleolus

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About: West Nile virus capsid protein induces p53‐mediated apoptosis via the sequestration of HDM2 to the nucleolus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	West Nile virus capsid protein induces p53‐mediated apoptosis via the sequestration of HDM2 to the nucleolus
Creator	Song, Jaewhan Lee, Sung Oh, Wonkyung Pyo, Suhkneung Shin, Jaekyoon Joo, Yi-Seok Lee, Eun-Woo Lee, Han-Woong Nah, Jin-Ju Yang, Mi-Ran Yeh, Jung-Yong
Source	Medline; PMC
abstract	The capsid protein of the West Nile virus (WNV) functions as an apoptotic agonist via the induction of mitochondrial dysfunction and the activation of caspases‐9 and ‐3. Here, we have determined that the WNV capsid (WNVCp) is capable of binding to and sequestering HDM2 into the nucleolus. WNVCp was shown to interfere with the formation of the HDM2 and p53 complex, thereby causing the stabilization of p53 and the subsequent induction of its target apoptotic protein, Bax. Whereas WNVCp was capable of inducing the p53‐dependent apoptotic process in wild‐type mouse embryonic fibroblasts (MEF) or SH‐SY5Y cells, it exerted no significant effects on p53‐null MEF or on p53‐knockdown SH‐SY5Y cells. This suggests that WNVCp‐mediated apoptosis requires p53. Furthermore, when WNV was transfected into cells, endogenous Hdm2 and WNVCp were able to interact physically. WNVCp expressed in wild‐type MEF proved able to induce the translocation of the endogenous Hdm2 into the nucleolus. Consistently, WNV was highly pathogenic in the presence of p53, and was less so in the absence of p53. The results of these studies suggest that the apoptotic mechanism mediated by WNV might occur in accordance in a fashion similar to that of the tumour‐suppressing mechanism mediated by ARF.
has issue date	2007-07-26(xsd:dateTime)
bibo:doi	10.1111/j.1462-5822.2007.01027.x
bibo:pmid	17697133
has license	no-cc
sha1sum (hex)	3c5f5c01cac275d5bbc0a794ba358f7fdebb36c8
schema:url	https://doi.org/10.1111/j.1462-5822.2007.01027.x
resource representing a document's title	West Nile virus capsid protein induces p53‐mediated apoptosis via the sequestration of HDM2 to the nucleolus
has PubMed Central identifier	PMC7162166
has PubMed identifier	17697133
schema:publication	Cell Microbiol
resource representing a document's body	covid:3c5f5c01cac275d5bbc0a794ba358f7fdebb36c8#body_text
is schema:about of	named entity 'fibroblasts' named entity 'cells' named entity 'mitochondrial' named entity 'nucleolus' named entity 'presence' named entity 'target' named entity 'apoptosis' named entity 'ACTIVATION' named entity 'WEST NILE VIRUS' named entity 'CAPSID PROTEIN' named entity 'MEDIATED' named entity 'NUCLEOLUS' named entity 'subsequent' named entity 'induction' named entity 'apoptotic' named entity 'highly' named entity 'physically' named entity 'caspases' named entity 'inducing' named entity 'wild-type' named entity 'process' named entity 'complex' named entity 'formation' named entity 'expressed' named entity 'West Nile virus' named entity 'protein' named entity 'agonist' named entity 'WNV' named entity 'endogenous' named entity 'capsid protein' named entity 'HDM2' named entity 'p53' named entity 'WNV' named entity 'nucleolus' named entity 'HDM2' named entity 'SH-SY5Y' named entity 'Plasmids' named entity 'Hdm2' named entity 'SDS-PAGE' named entity 'apoptosis' named entity 'ARF' named entity 'antibodies' named entity 'p53' named entity 'apoptotic' named entity 'HDM2' named entity 'HDM2' named entity 'MEF' named entity 'p53' named entity 'nucleolus' named entity 'MEF' named entity 'EGFP' named entity 'p53' named entity 'nucleolus' named entity 'caspase-8' named entity 'FACS' named entity 'biochemical processes' named entity 'wildtype' named entity 'p53' named entity 'HDM2' named entity 'transfection' named entity 'Bax' named entity 'hepatitis' named entity 'HDM2' named entity 'Bax' named entity 'RNA' named entity 'apoptotic' named entity 'GFP' named entity 'WNV' named entity 'Bax' named entity 'Bax' named entity 'Hdm2'

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