About: Scalable In-hospital Decontamination of N95 Filtering Facepiece Respirator with a Peracetic Acid Room Disinfection System

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About: Scalable In-hospital Decontamination of N95 Filtering Facepiece Respirator with a Peracetic Acid Room Disinfection System Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Scalable In-hospital Decontamination of N95 Filtering Facepiece Respirator with a Peracetic Acid Room Disinfection System
Creator	John, Amrita Li, F Curtis, ; Cadnum, Jennifer Daniel, ; Miller, Sharon Redmond, Sarah Akkus, Ozan Braskie, Melissa Buehler, Joy Donskey, J Hoyen, Claudia Jennings, Wayne Lee, Kipum Mcclellan, Phillip Raju, Shine
Source	MedRxiv
abstract	Abstract Background: Critical shortages of personal protective equipment (PPE) especially N95 respirators, during the SARS-CoV-2 pandemic continues to be a source of great concern among health care workers (HCWs). Novel methods of N95 filtering facepiece respirator (FFR) decontamination that can be scaled-up for in-hospital use can help address this concern and keep HCWs safe. Methods: A multidisciplinary pragmatic study was conducted to evaluate the use of an ultrasonic room high-level disinfection system (HLDS) that generates aerosolized peracetic acid (PAA) and hydrogen peroxide for decontamination of large numbers of N95 respirators. A cycle duration that consistently achieved disinfection of N95 respirators (defined as >6 log10 reductions in bacteriophage MS2 and Geobacillus stearothermophilus spores inoculated onto respirators) was identified. The treated masks were then assessed for changes to their hydrophobicity, material structure, strap elasticity, and filtration efficiency (FE). Assessment of PAA off-gassing from a treated mask was also performed. Results: The PAA room HLDS was effective for disinfection of N95 respirators in a 2447 cubic feet room with deploy and dwell times of 16 and 32 minutes respectively, and a total cycle time of 1 hour and 16 minutes. After 5 treatment cycles, no adverse effects were detected on filtration efficiency, structural integrity, or strap elasticity. There was no detectable off-gassing of PAA from the treated masks. Conclusion: The PAA room disinfection system provides a rapidly scalable solution for in-hospital decontamination of large numbers of N95 respirators to meet the needs of HCWs during the SARS-CoV-2 pandemic.
has issue date	2020-04-28(xsd:dateTime)
bibo:doi	10.1101/2020.04.24.20073973
has license	medrxiv
sha1sum (hex)	3bf6f4960d5475d5aba6be0f3186df123af82d0c
schema:url	https://doi.org/10.1101/2020.04.24.20073973
resource representing a document's title	Scalable In-hospital Decontamination of N95 Filtering Facepiece Respirator with a Peracetic Acid Room Disinfection System
resource representing a document's body	covid:3bf6f4960d5475d5aba6be0f3186df123af82d0c#body_text
is schema:about of	named entity 'Peracetic Acid' named entity 'Scalable' named entity 'Respirator' named entity 'N95' named entity 'Decontamination' named entity 'preprint' named entity 'N95' named entity 'preprint' named entity 'Filtration' named entity 'ultrasonic' named entity 'cellulose' named entity 'N95' named entity 'disinfection' named entity 'viscoelasticity' named entity 'COVID-19' named entity 'N95' named entity 'Respirators' named entity 'Bacteriophage MS2' named entity 'disinfection' named entity 'disinfectant' named entity 'phosphate-buffered saline' named entity 'disinfection' named entity 'moist heat' named entity 'preprint' named entity 'preprint' named entity 'aerosol' named entity 'US Food and Drug Administration' named entity 'preprint' named entity 'disinfection' named entity 'preprint' named entity 'Schematic diagram' named entity 'respirator' named entity 'disinfection' named entity 'disinfection' named entity 'preprint' named entity 'preprint' named entity 'preprint' named entity 'preprint' named entity 'University Hospitals Cleveland Medical Center' named entity 'preprint' named entity 'N95' named entity 'RNA' named entity 'peer review' named entity 'vaporized hydrogen peroxide' named entity 'preprint' named entity 'medRxiv' named entity 'preprint' named entity 'N95' named entity 'aerosols' named entity 'medRxiv' named entity 'Pittsburgh' named entity 'Vaporized hydrogen peroxide' named entity 'PPE' named entity 'NIOSH' named entity 'viral pathogens' named entity 'CDC' named entity 'tensile testing' named entity 'Figure 8' named entity 'PPE' named entity 'N95' named entity 'ultraviolet' named entity 'polycarbonate' named entity 'preprint' named entity 'disinfection' named entity 'preprint' named entity 'FFRs' named entity 'respirator' named entity 'fresh air' named entity 'mucus' named entity 'VHP'

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