About: Association between single nucleotide polymorphisms in TLR4, TLR2, TLR9, VDR, NOS2 and CCL5 genes with acute viral bronchiolitis

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About: Association between single nucleotide polymorphisms in TLR4, TLR2, TLR9, VDR, NOS2 and CCL5 genes with acute viral bronchiolitis Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Association between single nucleotide polymorphisms in TLR4, TLR2, TLR9, VDR, NOS2 and CCL5 genes with acute viral bronchiolitis
Creator	Corrêa, Ester Alvarez, Alfonso Augusto, Fernando Baracat, Elias Bastos, Santiago Cristina, Juliana Marson, Lima Ribeiro, José Weis Arns, Clarice Almeida, Bresciani Brandão, Marcelo Carlos, Emilio Conrado Dos Reis, Marcelo Cruz, Celize De Oliveira, Therezinha De Pieri, Vicente Ferreira De Miranda, Maria Romaneli, Neves Schlodtmann, Patricia Sílvia Bertuzzo, Carmen Tresoldi, Antônia Tresoldi, Mariana
Source	Elsevier; Medline; PMC
abstract	Abstract Background Acute viral bronchiolitis is the leading cause of hospitalization among infants during the first year of life. Most infants hospitalized for bronchiolitis do not present risk factors and are otherwise healthy. Our objective was to determine the genetic features associated with the risk and a severe course of bronchiolitis. Methods We prospectively evaluated 181 infants with severe bronchiolitis admitted at three hospitals over a 2-year period, who required oxygen therapy. The control group consisted of 536 healthy adults. Patients were evaluated for the presence of comorbidities (premature birth, chronic respiratory disease, and congenital heart disease), underwent nasopharyngeal aspirate testing for virus detection by multiplex-PCR, and SNPs identification in immune response genes. Patient outcomes were assessed. Results We observed association between SNP rs2107538CCL5 and bronchiolitis caused by respiratory syncytial virus(RSV) and RSV-subtype-A, and between rs1060826NOS2 and bronchiolitis caused by rhinovirus. SNPs rs4986790TLR4, rs1898830TLR2, and rs2228570VDR were associated with progression to death. SNP rs7656411TLR2 was associated with length of oxygen use; SNPs rs352162TLR9, rs187084TLR9, and rs2280788CCL5 were associated with requirement for intensive care unit admission; while SNPs rs1927911TLR4, rs352162TLR9, and rs2107538CCL5 were associated with the need for mechanical ventilation. Conclusions Our findings provide some evidence that SNPs in CCL5 and NOS2 are associated with presence of bronchiolitis and SNPs in TLR4, TLR2, TLR9, VDR and CCL5 are associated with severity of bronchiolitis.
has issue date	2018-03-01(xsd:dateTime)
bibo:doi	10.1016/j.gene.2017.12.022
bibo:pmid	29253610
has license	els-covid
sha1sum (hex)	39f4762231a3f1ef826f0ac195f5e47aeef39f3a
schema:url	https://doi.org/10.1016/j.gene.2017.12.022
resource representing a document's title	Association between single nucleotide polymorphisms in TLR4, TLR2, TLR9, VDR, NOS2 and CCL5 genes with acute viral bronchiolitis
has PubMed Central identifier	PMC7127094
has PubMed identifier	29253610
schema:publication	Gene
resource representing a document's body	covid:39f4762231a3f1ef826f0ac195f5e47aeef39f3a#body_text
is schema:about of	named entity 'ASSOCIATION' named entity 'SNPs' named entity 'leading' named entity 'presence' named entity 'infants' named entity 'NOS2' named entity 'CCL5' named entity 'detection' named entity 'bronchiolitis' named entity 'bronchiolitis' named entity 'ACUTE VIRAL BRONCHIOLITIS' named entity 'IDENTIFICATION' named entity 'NASOPHARYNGEAL ASPIRATE' named entity 'ADMISSION' named entity 'LENGTH' named entity 'WITH SEVERITY' named entity 'OUR' named entity 'MECHANICAL VENTILATION' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'CONTROL GROUP' named entity 'PRESENCE OF' named entity 'SNP' named entity 'LIFE' named entity 'SEVERE' named entity 'IMMUNE RESPONSE' named entity 'USE' named entity 'ADULTS' named entity 'RESULTS' named entity 'COMORBIDITIES' named entity 'HOSPITALIZATION' named entity 'TLR2' named entity 'VDR' named entity 'INTENSIVE CARE UNIT' named entity 'PROGRESSION' named entity 'DETERMINE' named entity 'DEATH' named entity 'RISK' named entity 'ASSOCIATION' named entity 'CAUSE' named entity 'TLR2' named entity 'TESTING' named entity 'NOT PRESENT' named entity 'CCL5' named entity 'RISK FACTORS' named entity 'METHODS' named entity 'PATIENT' named entity 'PCR' named entity 'SNPS' named entity 'VIRUS DETECTION' named entity 'GENES' named entity 'CCL5' named entity 'NEED FOR' named entity 'VDR' named entity 'TLR4' named entity 'TLR9' named entity 'SINGLE NUCLEOTIDE POLYMORPHISMS' named entity 'NOS2' named entity 'BIRTH' named entity 'RSV' named entity 'INFANTS'

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