About: Phylogenetic characterization of rhinoviruses from infants in Sarlahi, Nepal

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Phylogenetic characterization of rhinoviruses from infants in Sarlahi, Nepal
Creator	Kuypers, Jane Englund, Janet Jerome, Keith Katz, Joanne Khatry, Subarna Tielsch, James Perchetti, Garrett Chu, Helen Newman, Kira Steven, \| Leclerq, C
Source	Medline; PMC
abstract	PROBLEM: Rhinoviruses (RVs), the most common causes of acute respiratory infections in young children and infants, are highly diverse genetically. OBJECTIVE: To characterize the RV types detected with respiratory illness episodes in infants in Nepal. STUDY METHODS: Infants born to women enrolled in a randomized trial of maternal influenza immunization in rural, southern Nepal were followed with household‐based weekly surveillance until 180 days of age. Infants with respiratory symptoms had nasal swabs tested for twelve respiratory viruses. A subset with RV alone was selected for sequencing of the VP4/2 gene to identify RV types. RESULTS: Among 547 RV‐only positive illnesses detected from December 2012 to April 2014, 285 samples (52%) were sequenced. RV‐A, B, and C species were detected in 193 (68%), 18 (6%), and 74 (26%) specimens, respectively. A total of 94 unique types were identified from the sequenced samples, including 52 RV‐A, 11 RV‐B, and 31 RV‐C. Multiple species and types circulated simultaneously throughout the study period. No seasonality was observed. The median ages at illness onset were 88, 104, and 88 days for RV‐A, B, and C, respectively. The median polymerase chain reaction cycle threshold values did not differ between RV species. No differences between RV species were observed for reported respiratory symptoms, including pneumonia, or for medical care‐seeking. CONCLUSIONS: Among very young, symptomatic infants in rural Nepal, all three species and many types of RV were identified; RV‐A was detected most frequently. There was no association between RV species and disease severity.
has issue date	2019-08-21(xsd:dateTime)
bibo:doi	10.1002/jmv.25563
bibo:pmid	31389049
has license	no-cc
sha1sum (hex)	388280d5ebdb61d0a58fc34497aa361161f7c651
schema:url	https://doi.org/10.1002/jmv.25563
resource representing a document's title	Phylogenetic characterization of rhinoviruses from infants in Sarlahi, Nepal
has PubMed Central identifier	PMC6800797
has PubMed identifier	31389049
schema:publication	J Med Virol
resource representing a document's body	covid:388280d5ebdb61d0a58fc34497aa361161f7c651#body_text
is schema:about of	named entity 'infants' named entity 'genetically' named entity 'RVs' named entity 'Nepal' named entity 'viruses' named entity 'LRT' named entity 'RV-C' named entity 'pneumonia' named entity 'RV-B' named entity 'symptom' named entity 'gene sequences' named entity 'low birth weight' named entity 'viremia' named entity 'acute respiratory infections' named entity 'respiratory symptoms' named entity 'RV-C' named entity 'NCBI' named entity 'developing countries' named entity 'DNA Analyzer' named entity 'GenBank' named entity 'pediatric' named entity 'Sarlahi District' named entity 'lower respiratory tract' named entity 'PCR' named entity 'GenBank' named entity 'immunocompromised' named entity 'PCR' named entity 'respiratory symptom' named entity 'symptom' named entity 'symptom' named entity 'running water' named entity '21 days' named entity 'RV-C' named entity 'Phylogenetic trees' named entity 'bronchiolitis' named entity 'lower respiratory tract' named entity 'RV-C' named entity 'hospital care' named entity 'Applied Biosystems' named entity 'RV-C' named entity 'fever' named entity 'Germany' named entity 'Wilcoxon rank-sum' named entity 'RV-A' named entity 'medical care' named entity 'Nepal' named entity 'young children' named entity 'LRT' named entity 'epidemiology' named entity 'urban settings' named entity 'positive swab' named entity 'Nepal' named entity 'phylogenetic trees' named entity 'respiratory symptoms' named entity 'electricity' named entity 'immunization' named entity 'pneumonia' named entity 'Nepal' named entity 'pregnant women' named entity 'PCR' named entity 'asthma' named entity 'clinical signs' named entity 'maximum likelihood' named entity 'Hilden' named entity 'LRT' named entity 'difficulty breathing' named entity 'cough' named entity 'GenBank' named entity 'Nepal' named entity 'clinical findings' named entity 'Nepal'

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