About: Antibodies and Immunity During Kawasaki Disease

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antibodies and Immunity During Kawasaki Disease
Creator	Hicar, Mark Daniel Hicar, Mark Huang, Xupei Prentice, Howard Quan, Junjun
Source	Medline; PMC
abstract	The cause of Kawasaki disease (KD), the leading cause of acquired heart disease in children, is currently unknown. Epidemiology studies support that an infectious disease is involved in at least starting the inflammatory cascade set off during KD. Clues from epidemiology support that humoral immunity can have a protective effect. However, the role of the immune system, particularly of B cells and antibodies, in pathogenesis of KD is still unclear. Intravenous immunoglobulin (IVIG) and other therapies targeted at modulating inflammation can prevent development of coronary aneurysms. A number of autoantibody responses have been reported in children with KD and antibodies have been generated from aneurysmal plasma cell infiltrates. Recent reports show that children with KD have similar plasmablast responses as other children with infectious diseases, further supporting an infectious starting point. As ongoing studies are attempting to identify the etiology of KD through study of antibody responses, we sought to review the role of humoral immunity in KD pathogenesis, treatment, and recovery.
has issue date	2020-05-28(xsd:dateTime)
bibo:doi	10.3389/fcvm.2020.00094
bibo:pmid	32671098
has license	cc-by
sha1sum (hex)	382e8cab9b05bbf0a417eabca71e2c89c25e0a20
schema:url	https://doi.org/10.3389/fcvm.2020.00094
resource representing a document's title	Antibodies and Immunity During Kawasaki Disease
has PubMed Central identifier	PMC7326051
has PubMed identifier	32671098
schema:publication	Front Cardiovasc Med
resource representing a document's body	covid:382e8cab9b05bbf0a417eabca71e2c89c25e0a20#body_text
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