About: Stage of Gestation at Porcine Epidemic Diarrhea Virus Infection of Pregnant Swine Impacts Maternal Immunity and Lactogenic Immune Protection of Neonatal Suckling Piglets

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Stage of Gestation at Porcine Epidemic Diarrhea Virus Infection of Pregnant Swine Impacts Maternal Immunity and Lactogenic Immune Protection of Neonatal Suckling Piglets Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Stage of Gestation at Porcine Epidemic Diarrhea Virus Infection of Pregnant Swine Impacts Maternal Immunity and Lactogenic Immune Protection of Neonatal Suckling Piglets
Creator	Steinbach, Falko Vlasova, Anastasia Lager, Kelly Saif, Linda Faldyna, Martin Buckley, Alexandra Van Geelen, Albert Alhamo, Moyasar Hernandez, Jesus Langel, Stephanie Paim, Francine
topic	covid:360ab35f1a888c57572270161254de77913951be#this
Source	Medline; PMC
abstract	During pregnancy, the maternal immune response changes dramatically over the course of gestation. This has implications for generation of lactogenic immunity and subsequent protection in suckling neonates against enteric viral infections. For example, porcine epidemic diarrhea virus (PEDV) is an alphacoronavirus that causes acute diarrhea in neonatal piglets. Due to the high virulence of PEDV and the naïve, immature immune system of neonatal suckling piglets, passive lactogenic immunity to PEDV induced during pregnancy, via the gut-mammary gland (MG)-secretory IgA (sIgA) axis, is critical for piglet protection. However, the anti-PEDV immune response during pregnancy and stage of gestation required to optimally stimulate the gut-MG-sIgA axis is undefined. We hypothesize that there is a gestational window in which non-lethal PEDV infection of pregnant gilts influences maximum lymphocyte mucosal trafficking to the MG, resulting in optimal passive lactogenic protection in suckling piglets. To understand how the stages of gestation affect maternal immune responses to PEDV, three groups of gilts were orally infected with PEDV in the first, second or third trimester. Control (mock) gilts were inoculated with medium in the third trimester. To determine if lactogenic immunity correlated with protection, all piglets were PEDV-challenged at 3–5 days postpartum. PEDV infection of gilts at different stages of gestation significantly affected multiple maternal systemic immune parameters prepartum, including cytokines, B cells, PEDV antibodies (Abs), and PEDV antibody secreting cells (ASCs). Pregnant second trimester gilts had significantly higher levels of circulating PEDV IgA and IgG Abs and ASCs and PEDV virus neutralizing (VN) Abs post PEDV infection. Coinciding with the significantly higher PEDV Ab responses in second trimester gilts, the survival rate of their PEDV-challenged piglets was 100%, compared with 87.2, 55.9, and 5.7% for first, third, and mock litters, respectively. Additionally, piglet survival positively correlated with PEDV IgA Abs and ASCs and VN Abs in milk and PEDV IgA and IgG Abs in piglet serum. Our findings have implications for gestational timing of oral attenuated PEDV maternal vaccines, whereby PEDV intestinal infection in the second trimester optimally stimulated the gut-MG-sIgA axis resulting in 100% lactogenic immune protection in suckling piglets.
has issue date	2019-04-24(xsd:dateTime)
bibo:doi	10.3389/fimmu.2019.00727
bibo:pmid	31068924
has license	cc-by
sha1sum (hex)	360ab35f1a888c57572270161254de77913951be
schema:url	https://doi.org/10.3389/fimmu.2019.00727
resource representing a document's title	Stage of Gestation at Porcine Epidemic Diarrhea Virus Infection of Pregnant Swine Impacts Maternal Immunity and Lactogenic Immune Protection of Neonatal Suckling Piglets
has PubMed Central identifier	PMC6491507
has PubMed identifier	31068924
schema:publication	Front Immunol
resource representing a document's body	covid:360ab35f1a888c57572270161254de77913951be#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/360ab35f1a888c57572270161254de77913951be
is schema:about of	named entity 'VIRUS INFECTION' named entity 'PREGNANT' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'SWINE' named entity 'CORRELATED' named entity 'SIGA' named entity 'CHANGES' named entity 'IGA' named entity 'VIRUS' named entity 'NEONATAL' named entity 'IMMUNITY' named entity 'CELLS' named entity 'IMMUNE RESPONSE' named entity 'UNDEFINED' named entity 'REQUIRED' named entity 'SECRETORY IGA' named entity 'POSITIVELY CORRELATED' named entity 'SECOND TRIMESTER' named entity 'ALPHACORONAVIRUS' named entity 'MOCK' named entity 'MULTIPLE' named entity 'DETERMINE' named entity 'ANTIBODIES' named entity 'THIRD TRIMESTER' named entity 'INDUCED' named entity 'CRITICAL' named entity 'CAUSES' named entity 'SECOND OR THIRD TRIMESTER' named entity 'COMPARED' named entity 'INFECTION' named entity 'POST' named entity 'IGG' named entity 'AFFECT' named entity 'STAGES' named entity 'COURSE' named entity 'THEIR' named entity 'HIGH' named entity 'LEVELS' named entity '5.7' named entity 'GESTATIONAL' named entity 'INCLUDING' named entity 'STAGE' named entity 'AXIS' named entity 'MEDIUM' named entity 'STIMULATE' named entity 'HOW' named entity 'PREGNANT' named entity 'GENERATION' named entity 'NEONATES' named entity 'LYMPHOCYTE' named entity 'POSTPARTUM' named entity 'VIRAL INFECTIONS' named entity 'SURVIVAL RATE' named entity 'WINDOW' named entity 'B CELLS' named entity 'VIRULENCE' named entity 'RESULTING IN' named entity 'INFECTED' named entity 'DIFFERENT' named entity 'SUBSEQUENT' covid:arg/360ab35f1a888c57572270161254de77913951be named entity 'GESTATION' named entity 'SYSTEMIC' named entity 'UNDERSTAND' named entity 'IMPACTS' named entity 'EXAMPLE' named entity 'GESTATION' named entity 'MATERNAL' named entity 'IMMUNITY'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software