About: Synthesis and in vitro cytostatic activity of new β-d-arabino furan[1′,2′:4,5]oxazolo- and arabino-pyrimidinone derivatives

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About: Synthesis and in vitro cytostatic activity of new β-d-arabino furan[1′,2′:4,5]oxazolo- and arabino-pyrimidinone derivatives Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Synthesis and in vitro cytostatic activity of new β-d-arabino furan[1′,2′:4,5]oxazolo- and arabino-pyrimidinone derivatives
Creator	Balzarini, Jan Bosc, Jean-Jacques Forfar, Isabelle Guillon, Jean Jarry, Christian Latxague, Laurent Lé, Jean-Michel
Source	Elsevier; Medline; PMC
abstract	Abstract A series of nucleoside derivatives was obtained via heteroatom annulation of the amino oxazoline of d-(−)-arabinose. Unequivocal proofs for the stereostructure of some new arabinosyl pyrimidinone derivatives were obtained by X-ray structure analysis. These newly synthesized compounds were then evaluated for their cytostatic activity against murine leukemia (L1210), and human T-lymphocytes (Molt 4/C8 and CEM). Of all the compounds in the series, the protected silylated tricyclic fused pyrimidinone 10 showed the most significant antitumor activity against murine leukemia L1210 (IC50 =6μM), and human T-lymphocytes cells Molt 4/C8 (IC50 =7.9μM) and CEM/0 cell lines (IC50 =7.5μM). None of the compounds exhibited significant antiviral inhibitory activities.
has issue date	2010-02-28(xsd:dateTime)
bibo:doi	10.1016/j.ejmech.2009.10.032
bibo:pmid	19910080
has license	els-covid
sha1sum (hex)	3456d77417741132134d0b3d2e2242ed3d04f3eb
schema:url	https://doi.org/10.1016/j.ejmech.2009.10.032
resource representing a document's title	Synthesis and in vitro cytostatic activity of new β-d-arabino furan[1′,2′:4,5]oxazolo- and arabino-pyrimidinone derivatives
has PubMed Central identifier	PMC7115621
has PubMed identifier	19910080
schema:publication	European Journal of Medicinal Chemistry
resource representing a document's body	covid:3456d77417741132134d0b3d2e2242ed3d04f3eb#body_text
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