About: Relative antioxidant activities of quercetin and its structurally related substances and their effects on NF-κB/CRE/AP-1 signaling in murine macrophages

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About: Relative antioxidant activities of quercetin and its structurally related substances and their effects on NF-κB/CRE/AP-1 signaling in murine macrophages Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Relative antioxidant activities of quercetin and its structurally related substances and their effects on NF-κB/CRE/AP-1 signaling in murine macrophages
Creator	Kim, Byung-Hak Kim, Myoung-Hwan Lee, Jin-Ku Won, Cheolhee Ye, Sang-Kyu Choi, Jung Yi, Eun
source	PMC
abstract	Reactive oxygen species (ROS) and reactive nitrogen species (RNS) produced by the oxidative burst in activated macrophages and neutrophils cause oxidative stressimplicated diseases. Quercetin is flavonoid that occurs naturally in plants and is widely used as a nutritional supplement due to its antioxidant and anti-inflammatory properties. In this study, we investigated antioxidant activities and mechanisms of action in zymosan-induced macrophages of quercetin and quercetin-related flavonoids such as quercitrin, isoquercitrin, quercetin 3-O-β-(2″-galloyl)-rhamnopyranoside (QGR) and quercetin 3-O-β-(2″-galloyl)-glucopyranoside (QGG) as well as gallic acid, a building moiety of QGR and QGG. QGR and QGG exhibited stronger antioxidant activities compared with quercetin, whereas quercitrin, isoquercitrin and gallic acid exhibited weak-tono antioxidant activities, assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, superoxide production, superoxide scavenging, nitric oxide (NO) production, peroxynitrite (ONOO(−)) scavenging and myeloperoxidase (MPO) activity. Regarding mechanisms, the quercetincontaining flavonoids QGR and QGG differentially targeted compared with quercetin in the NF-κB signaling pathway that inhibited the DNA binding activity of the NF-κB complex without affecting the degradation and phosphorylation of IκBα and NF-κB phosphorylation. In addition, QGR and QGG inhibited CRE and activator protein (AP-1) transcriptional activity and JNK phosphorylation by inhibiting the cAMP/protein kinase A (PKA) and protein kinase C (PKC) signaling in a different manner than quercetin. Our results showed that although QGR and QGG exhibited stronger antioxidant activities than querce-tin in macrophages, their mechanisms of action in terms of the NF-κB, PKA and PKC signaling pathways were different.
has issue date	2013-05-01(xsd:dateTime)
bibo:doi	10.1007/s10059-013-0031-z
bibo:pmid	23649461
has license	green-oa
sha1sum (hex)	32089db17a5a717895c6732dbb0732335b43de78
schema:url	https://doi.org/10.1007/s10059-013-0031-z
resource representing a document's title	Relative antioxidant activities of quercetin and its structurally related substances and their effects on NF-κB/CRE/AP-1 signaling in murine macrophages
has PubMed Central identifier	PMC3887868
has PubMed identifier	23649461
schema:publication	Molecules and Cells
resource representing a document's body	covid:32089db17a5a717895c6732dbb0732335b43de78#body_text
is schema:about of	named entity 'plants' named entity 'phosphorylation' named entity 'production' named entity 'Reactive oxygen species (ROS)' named entity 'radical' named entity 'CRE' named entity 'Related' named entity 'Macrophages' named entity 'RELATIVE' named entity 'BAB' named entity 'PROPERTIES' named entity 'REACTIVE NITROGEN SPECIES' named entity 'DEGRADATION' named entity '282' named entity 'OXIDATIVE BURST' named entity 'MYELOPEROXIDASE' named entity 'FLAVONOID' named entity 'ACTIVITIES' named entity 'WEAK' named entity 'PEROXYNITRITE' named entity 'CRE' named entity 'BAB' named entity 'TERMS' named entity 'QUERCITRIN' named entity 'ACTION' named entity 'ADDITION' named entity 'SUBSTANCES' named entity 'ISOQUERCITRIN' named entity 'TARGETED' named entity 'INDUCED' named entity 'THEIR' named entity 'PHOSPHORYLATION' named entity 'JNK' named entity 'RADICAL' named entity 'MURINE MACROPHAGES' named entity 'RELATED' named entity 'ACTIVITIES' named entity 'ITS' named entity 'SIGNALING' named entity 'THEIR' named entity 'ANTIOXIDANT' named entity 'BUILDING' named entity 'GALLIC ACID' named entity 'ZYMOSAN' named entity 'MACROPHAGES' named entity 'ANTIOXIDANT' named entity 'STUDY' named entity 'DISEASES' named entity 'QUERCETIN' named entity 'EFFECTS' named entity 'USED' named entity 'PLANTS' named entity 'MOIETY' named entity 'DIPHENYL' named entity 'COMPARED' named entity 'DIFFERENT' named entity 'NUTRITIONAL SUPPLEMENT' named entity 'DNA BINDING ACTIVITY' named entity 'INVESTIGATED' named entity 'REACTIVE OXYGEN SPECIES' named entity 'RELATED' named entity 'FLAVONOIDS' named entity 'ITS' named entity 'DUE TO' named entity 'SUPEROXIDE' named entity 'INHIBITING' named entity 'TRANSCRIPTIONAL ACTIVITY' named entity 'COMPLEX' named entity 'ASSESSED' named entity 'SIGNALING PATHWAYS' named entity 'AFFECTING' named entity 'QUERCETIN' named entity 'PRODUCTION' named entity 'ACTIVITY' named entity 'TIN'

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