About: Infectious Bronchitis Virus Regulates Cellular Stress Granule Signaling

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Infectious Bronchitis Virus Regulates Cellular Stress Granule Signaling
Creator	Doyle, Nicole Locker, Nicolas Maier, Helena Brocard, Michèle Brownsword, Matthew
Source	Medline; PMC
abstract	Viruses must hijack cellular translation machinery to express viral genes. In many cases, this is impeded by cellular stress responses. These stress responses result in the global inhibition of translation and the storage of stalled mRNAs, into RNA-protein aggregates called stress granules. This results in the translational silencing of the majority of mRNAs excluding those beneficial for the cell to resolve the specific stress. For example, the expression of antiviral factors is maintained during viral infection. Here we investigated stress granule regulation by Gammacoronavirus infectious bronchitis virus (IBV), which causes the economically important poultry disease, infectious bronchitis. Interestingly, we found that IBV is able to inhibit multiple cellular stress granule signaling pathways, whilst at the same time, IBV replication also results in the induction of seemingly canonical stress granules in a proportion of infected cells. Moreover, IBV infection uncouples translational repression and stress granule formation and both processes are independent of eIF2α phosphorylation. These results provide novel insights into how IBV modulates cellular translation and antiviral stress signaling.
has issue date	2020-05-14(xsd:dateTime)
bibo:doi	10.3390/v12050536
bibo:pmid	32422883
has license	cc-by
sha1sum (hex)	31ef24e2649ed41fb2a13de4b343452022018d3a
schema:url	https://doi.org/10.3390/v12050536
resource representing a document's title	Infectious Bronchitis Virus Regulates Cellular Stress Granule Signaling
has PubMed Central identifier	PMC7291021
has PubMed identifier	32422883
schema:publication	Viruses
resource representing a document's body	covid:31ef24e2649ed41fb2a13de4b343452022018d3a#body_text
is schema:about of	named entity 'proportion' named entity 'economically' named entity 'translation' named entity 'translation' named entity 'genes' named entity 'Signaling' named entity 'GLOBAL' named entity 'BENEFICIAL' named entity 'EXPRESSION' named entity 'HERE' named entity 'PROPORTION' named entity 'STORAGE' named entity 'SILENCING' named entity 'GAMMACORONAVIRUS' named entity 'VIRAL INFECTION' named entity 'INSIGHTS' named entity 'STRESS' named entity 'SIGNALING PATHWAYS' named entity 'MAJORITY' named entity 'IBV' named entity 'translational' named entity 'infectious bronchitis' named entity 'mRNAs' named entity 'global' named entity 'processes' named entity 'express' named entity 'stress responses' named entity 'modulates' named entity 'mRNAs' named entity 'independent' named entity 'provide' named entity 'cellular' named entity 'stress granule' named entity 'mRNAs' named entity 'IBV' named entity 'protein aggregates' named entity 'viral infection' named entity 'poultry' named entity 'stress responses' named entity 'IBV' named entity 'cellular stress' named entity 'mRNAs' named entity 'Gammacoronavirus' named entity 'Viruses' named entity 'stress granules' named entity 'antiviral' named entity 'uncouples' named entity 'eIF2α' named entity 'antibodies' named entity 'virus' named entity 'phosphorylation' named entity 'sodium arsenite' named entity 'RNA' named entity 'infection' named entity 'DAPI' named entity 'G3BP1' named entity 'PBS' named entity 'stress granules' named entity 'kinase' named entity 'phosphorylation' named entity 'specific granules' named entity 'kinase' named entity 'virus' named entity 'sodium arsenite' named entity 'cycloheximide' named entity 'hpi' named entity 'phosphorylation' named entity 'Fluorescent in situ Hybridization' named entity 'antibody' named entity 'phosphorylation' named entity 'secondary antibody' named entity 'single cell' named entity 'dephosphorylation' named entity 'infection' named entity 'dsRNA' named entity 'IBV' named entity 'ribosomes'

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