About: Arf Proteins and Their Regulators: At the Interface Between Membrane Lipids and the Protein Trafficking Machinery

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Arf Proteins and Their Regulators: At the Interface Between Membrane Lipids and the Protein Trafficking Machinery
Creator	Jackson, Catherine Jackson, C
Source	PMC
abstract	The Arf small GTP-binding (G) proteins regulate membrane traffic and organelle structure in eukaryotic cells through a regulated cycle of GTP binding and hydrolysis. The first function identified for Arf proteins was recruitment of cytosolic coat complexes to membranes to mediate vesicle formation. However, subsequent studies have uncovered additional functions, including roles in plasma membrane signalling pathways, cytoskeleton regulation, lipid droplet function, and non-vesicular lipid transport. In contrast to other families of G proteins, there are only a few Arf proteins in each organism, yet they function specifically at many different cellular locations. Part of this specificity is achieved by formation of complexes with their guanine nucleotide-exchange factors (GEFs) and GTPase activating proteins (GAPs) that catalyse GTP binding and hydrolysis, respectively. Because these regulators outnumber their Arf substrates by at least 3-to-1, an important aspect of understanding Arf function is elucidating the mechanisms by which a single Arf protein is incorporated into different GEF, GAP, and effector complexes. New insights into these mechanisms have come from recent studies showing GEF–effector interactions, Arf activation cascades, and positive feedback loops. A unifying theme in the function of Arf proteins, carried out in conjunction with their regulators and effectors, is sensing and modulating the properties of the lipids that make up cellular membranes.
has issue date	2014-05-22(xsd:dateTime)
bibo:doi	10.1007/978-3-319-07761-1_8
has license	no-cc
sha1sum (hex)	319eb2b655887aed733233c6c7da197486ee920b
schema:url	https://doi.org/10.1007/978-3-319-07761-1_8
resource representing a document's title	Arf Proteins and Their Regulators: At the Interface Between Membrane Lipids and the Protein Trafficking Machinery
has PubMed Central identifier	PMC7123483
schema:publication	Ras Superfamily Small G Proteins: Biology and Mechanisms 2
resource representing a document's body	covid:319eb2b655887aed733233c6c7da197486ee920b#body_text
is schema:about of	named entity 'carried' named entity 'GAP' named entity 'cascades' named entity 'cytosolic' named entity 'function' named entity 'function' named entity 'plasma membrane' named entity 'catalyse' named entity 'membranes' named entity 'Trafficking' named entity 'membrane contact site' named entity 'Lipids' named entity 'CLASS I' named entity 'EUKARYOTIC CELLS' named entity 'MEDIATE' named entity 'COAT' named entity 'INTERACTIONS' named entity 'ASPECT' named entity 'INSIGHTS' named entity 'LOCATIONS' named entity 'HYDROLYSIS' named entity 'CELLULAR' named entity 'GTP BINDING' named entity 'SENSING' named entity 'RECENT' named entity 'membrane' named entity 'effectors' named entity 'function' named entity 'conjunction' named entity 'mechanisms' named entity 'contrast' named entity 'formation' named entity 'effector' named entity 'lipid' named entity 'Springer International Publishing' named entity 'traffic' named entity 'complexes' named entity 'loops' named entity 'activation' named entity 'The' named entity 'mechanisms' named entity 'guanine' named entity 'GTP binding and hydrolysis' named entity 'Arf' named entity 'GEF' named entity 'GTP binding and hydrolysis' named entity 'Arf' named entity 'plasma membrane' named entity 'positive feedback loops' named entity 'eukaryotic cells' named entity 'signalling pathways' named entity 'GEF' named entity 'MCS' named entity 'Arf' named entity 'coat protein' named entity 'guanine' named entity 'membrane contact site' named entity 'complex formation' named entity 'GEFs' named entity 'protein' named entity 'Shigella flexneri' named entity 'C-terminal' named entity 'vesicles' named entity 'closely resembles' named entity 'Arf protein' named entity 'plasma membrane' named entity 'Arf' named entity 'Arf' named entity 'Arf6' named entity 'Arf1' named entity 'parasite' named entity 'Koumandou' named entity 'cytohesin' named entity 'Arf' named entity 'Sec7' named entity 'GTP' named entity 'lipid transfer proteins' named entity 'protein' named entity 'phosphatidylcholine' named entity 'periventricular' named entity 'GBF1' named entity 'concentration gradient'

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