About: A Case Report: Minimal Change Disease with Nephrotic Syndrome Associated with COVID-19 after APOL1 risk variant Kidney Transplantation

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About: A Case Report: Minimal Change Disease with Nephrotic Syndrome Associated with COVID-19 after APOL1 risk variant Kidney Transplantation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Case Report: Minimal Change Disease with Nephrotic Syndrome Associated with COVID-19 after APOL1 risk variant Kidney Transplantation
Creator	Smith, Richard Smith, H Corresponding, # Ince, Dilek Kuppachi, Sarat Mansilla, M Rastogi, Prerna Thayyil, Abdullah Thomas, Christie Yamada, Masaaki
Source	Elsevier; PMC
abstract	Abstract Kidney injury is a well-known complication in people with coronavirus disease 2019 (COVID-19). In kidney transplant recipients with COVID-19, presentation with nephrotic syndrome has not been well described. We report on a 49-year-old African American female kidney transplant recipient who presented 25 years after transplantation with clinical features of nephrotic syndrome following a diagnosis of COVID-19. Histological examination showed acute tubular injury with unremarkable glomeruli on light microscopy and diffuse foot process effacement of podocytes on electron microscopy, consistent with minimal change–like podocyte injury. Apolipoprotein L1 (APOL1) genetic testing confirmed two high-risk APOL1 alleles in the kidney donor. We speculate that COVID-19-induced systemic or local cytokine release could serve as a second hit in the presence of APOL1 risk alleles and mediate a podocytopathy manifesting as nephrotic syndrome. The presented case with minimal change like disease, occurring in the context of the donor high-risk APOL1 genotype, extends the spectrum of clinical manifestations in COVID-19-associated nephropathy.
has issue date	2020-08-20(xsd:dateTime)
bibo:doi	10.1016/j.transproceed.2020.08.012
has license	els-covid
sha1sum (hex)	319cc65987d303d39650e4755efc3fd278c64e9d
schema:url	https://doi.org/10.1016/j.transproceed.2020.08.012
resource representing a document's title	A Case Report: Minimal Change Disease with Nephrotic Syndrome Associated with COVID-19 after APOL1 risk variant Kidney Transplantation
has PubMed Central identifier	PMC7440148
schema:publication	Transplant Proc
resource representing a document's body	covid:319cc65987d303d39650e4755efc3fd278c64e9d#body_text
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