About: An Impaired Breeding Phenotype in Mice with a Genetic Deletion of Beta-2 Microglobulin and Diminished MHC Class I Expression: Role in Reproductive Fitness(1)

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About: An Impaired Breeding Phenotype in Mice with a Genetic Deletion of Beta-2 Microglobulin and Diminished MHC Class I Expression: Role in Reproductive Fitness(1) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	An Impaired Breeding Phenotype in Mice with a Genetic Deletion of Beta-2 Microglobulin and Diminished MHC Class I Expression: Role in Reproductive Fitness(1)
Creator	Arck, Petra Ahmed, Mohamed Blois, Sandra Cooper, Joanne Dealtry, Gillian Fernández, Nelson Klapp, Burghard
Source	PMC
abstract	Beta-2 microglobulin (B2M) plays a pivotal role in the biology of mammals, including its association with major histocompatibility complex (MHC) Class I gene products. The latter molecules have been shown to affect reproduction in both mice and humans, although the exact mechanism is still unknown. Here we report the results of a longitudinal study of the reproductive performance of a genetically modified B2m deficient mouse strain with low MHC Class I expression. Our data show that this mouse strain has an impaired reproductive performance. However, the mice superovulate well and show a normal estrous cycle. Breeding studies from crosses between the transgenic mice and the wild-type parental strain show that B2m deficient mice have a significantly lower frequency of mating than the control B2m(+/+) mice. In addition, the litter size and weaning success of B2m deficient mice were lower than the control. Perinatal lethality of the B2m deficient offspring was also inflicted by cannibalism of the young pups by the B2m deficient female. The impaired breeding phenotype (IBP) can be reversed by reintroducing the B2m gene in F1 heterozygous B2m(+/−) animals; thus the presence of B2M confers a normal breeding pattern. The acquisition of an impaired breeding phenotype (IBP) as a result of the knockout of B2m directly implicates B2M in the reproductive cycle of mice and raises the possibility of an effect of B2M on the reproduction of other mammals.
has issue date	2007-08-01(xsd:dateTime)
bibo:doi	10.1095/biolreprod.106.057125
bibo:pmid	17442853
has license	no-cc
sha1sum (hex)	308b29a1d34962e9f4188d69c42d5efa7626b4a4
schema:url	https://doi.org/10.1095/biolreprod.106.057125
resource representing a document's title	An Impaired Breeding Phenotype in Mice with a Genetic Deletion of Beta-2 Microglobulin and Diminished MHC Class I Expression: Role in Reproductive Fitness(1)
has PubMed Central identifier	PMC7110103
has PubMed identifier	17442853
schema:publication	Biol Reprod
resource representing a document's body	covid:308b29a1d34962e9f4188d69c42d5efa7626b4a4#body_text
is schema:about of	named entity 'IMPAIRED' named entity 'DIMINISHED' named entity 'Expression' named entity 'Breeding' named entity 'HAVE' named entity 'ASSOCIATION' named entity 'ROLE' named entity 'MICE' named entity 'GENE' named entity 'PRODUCTS' named entity 'MOLECULES' named entity 'ITS' covid:arg/308b29a1d34962e9f4188d69c42d5efa7626b4a4 named entity 'DELETION' named entity 'MAMMALS' named entity 'REPRODUCTIVE' named entity 'HUMANS' named entity 'MAJOR HISTOCOMPATIBILITY COMPLEX' named entity 'INCLUDING' named entity 'BIOLOGY' named entity 'BETA-2 MICROGLOBULIN' named entity 'MHC CLASS I' named entity 'BREEDING' named entity 'AFFECT' named entity 'PHENOTYPE' named entity 'ROLE' named entity 'GENETIC' named entity 'EXPRESSION' named entity 'FITNESS' named entity 'PLAYS' named entity 'MICE' named entity 'BETA-2 MICROGLOBULIN' named entity 'MECHANISM' named entity 'CLASS I' named entity 'UNKNOWN' named entity 'EXACT' named entity 'REPRODUCTION' named entity 'Beta-2 microglobulin' named entity 'Beta-2 Microglobulin' named entity 'Phenotype' named entity 'exact' named entity 'normal development' named entity 'mouse hepatitis virus' named entity 'B2m' named entity 'B2m' named entity 'B2m' named entity 'cannibalism' named entity 'early development' named entity 'fosB' named entity 'MHC' named entity 'homozygous' named entity 'serum' named entity 'exact mechanism' named entity 'death rate' named entity 'antigen' named entity 'mice' named entity 'C57BL/6' named entity 'Phenotype' named entity 'mice' named entity 'hCG' named entity 'Dalton' named entity 'mice' named entity 'MHC' named entity 'mucus' named entity 'mice' named entity 'mice' named entity 'B2M' named entity 'B2m' named entity 'wild-type' named entity 'B2m' named entity 'CD8' named entity 'postnatal mortality' named entity 'mice' named entity 'CD1' named entity '0.01'

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