About: Isolation, Characterization, and Molecular Modeling of a Rheumatoid Factor from a Hepatitis C Virus Infected Patient with Sjögren's Syndrome

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About: Isolation, Characterization, and Molecular Modeling of a Rheumatoid Factor from a Hepatitis C Virus Infected Patient with Sjögren's Syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Isolation, Characterization, and Molecular Modeling of a Rheumatoid Factor from a Hepatitis C Virus Infected Patient with Sjögren's Syndrome
Creator	Lee, Yu-Ching Leu, Sy-Jye Liu, Chia-Yu Tsai, Keng-Chang Wang, Tuan-Jen Yang, Yi-Yuan Cava, La Muro, Y
Source	PMC
abstract	We have previously isolated several IgG rheumatoid factors (RFs) from patients with both rheumatoid arthritis and idiopathic thrombocytopenia purpura using phage display system. To study IgG RFs in patients with other autoimmune diseases, phage display antibody libraries from a hepatitis C virus infected patient with Sjögren's syndrome were constructed. After panning, a specific clone RFL11 was isolated for characterization in advance. The binding activity and specificity of RFL11 to IgG Fc fragment were comparable to those of RFs previously isolated. The analysis with existed RF-Fc complex structures indicated the homology model of RFL11 is similar to IgM RF61 complex with high binding affinity of about 6 × 10(−8) M. This effect resulted from longer complementarity-determining region (CDR) combining key somatic mutations. In the RFL11-Fc interfaces, the CDR-H3 loop forms a finger-like structure extending into the bottom of Fc pocket and resulting in strong ion and cation-pi interactions. Moreover, a process of antigen-driven maturation was proven by somatically mutated VH residues on H2 and H3 CDR loops in the interfaces. Taken together, these results suggested that high affinity IgG RFs can be generated in patients with Sjögren's syndrome and may play an important role in the pathogenesis of this autoimmune disease.
has issue date	2013-12-30(xsd:dateTime)
bibo:doi	10.1155/2013/516516
bibo:pmid	24489505
has license	cc-by
sha1sum (hex)	30556242d064131f0f2b645a727d42c55dc1c71e
schema:url	https://doi.org/10.1155/2013/516516
resource representing a document's title	Isolation, Characterization, and Molecular Modeling of a Rheumatoid Factor from a Hepatitis C Virus Infected Patient with Sjögren's Syndrome
has PubMed Central identifier	PMC3892945
has PubMed identifier	24489505
schema:publication	ScientificWorldJournal
resource representing a document's body	covid:30556242d064131f0f2b645a727d42c55dc1c71e#body_text
is schema:about of	named entity 'A HEPATITIS' named entity 'PATIENT' named entity 'USING' named entity 'STRUCTURE' named entity 'AFFINITY' named entity 'COMBINING' named entity 'PREVIOUSLY' named entity 'LIKE' named entity 'INTERACTIONS' named entity 'EFFECT' named entity 'PATIENTS' named entity 'ROLE' named entity 'FC FRAGMENT' named entity 'ANTIGEN' named entity 'IGG' named entity 'CLONE' named entity 'SPECIFICITY' named entity '27S' named entity 'CONSTRUCTED' named entity 'COMPLEX' named entity 'IMPORTANT' named entity 'MODEL OF' named entity 'THESE' named entity 'ADVANCE' named entity 'AUTOIMMUNE DISEASES' named entity 'HAVE' named entity 'MUTATED' named entity 'SPECIFIC' named entity 'ABOUT' named entity 'TAKEN' named entity 'PROVEN' named entity 'KEY' named entity 'SIMILAR' named entity 'BINDING ACTIVITY' named entity 'ANALYSIS' named entity 'ION' named entity 'A HEPATITIS' named entity 'SOMATIC MUTATIONS' named entity 'HEPATITIS C VIRUS' named entity 'RESULTING IN' named entity 'PROCESS' named entity 'RHEUMATOID FACTOR' named entity 'STUDY' named entity 'SYNDROME' named entity 'MATURATION' named entity 'HOMOLOGY MODEL' named entity 'PLAY' covid:arg/30556242d064131f0f2b645a727d42c55dc1c71e named entity 'STRONG' named entity 'RESULTS' named entity 'LOOPS' named entity 'INDICATED' named entity 'FORMS' named entity 'IGM' named entity 'CHARACTERIZATION' named entity 'ISOLATION' named entity 'HEPATITIS C VIRUS' named entity 'INFECTED' named entity 'MOLECULAR MODELING' named entity '27S' named entity 'SYNDROME' named entity 'AUTOIMMUNE DISEASE' named entity 'LIBRARIES' named entity 'THE BOTTOM' named entity 'CDR-H3' named entity 'ANTIBODY' named entity 'FINGER' named entity 'DRIVEN' named entity 'PANNING' named entity '928' named entity 'RHEUMATOID ARTHRITIS' named entity 'PATIENT' named entity 'RFS' named entity 'HIGH'

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