About: Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection
Creator	Gouma, Sigrid Betts, Michael Meyer, Nuala Hensley, Scott Wherry, E Agyekum, Roseline Anderson, Elizabeth Apostolidis, Sokratis Arevalo, Claudia Baxter, Amy Bershaw, Luanne Bolton, Marcus Goodwin, Eileen Greenplate, Allison Han, Nicholas Ittner, Caroline Jones, Tiffanie Kim, Justin Kuri-Cervantes, Leticia Kuthuru, Oliva Mangalmurti, Nilam Mathew, Divij Meng, Wenzhao Pattekar, Ajinkya Rosenfeld, Aaron Vella, Laura Weirick, Madison Weisman, Ariel Betina Pampena, M Prak, Eline Dougherty, Jeannete
Source	BioRxiv; Medline
abstract	Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified broad changes in neutrophils, NK cells, and monocytes during severe COVID-19, suggesting excessive mobilization of innate lineages. We found marked activation within T and B cells, highly oligoclonal B cell populations, profound plasmablast expansion, and SARS-CoV-2-specific antibodies in many, but not all, severe COVID-19 cases. Despite this heterogeneity, we found selective clustering of severe COVID-19 cases through unbiased analysis of the aggregated immunological phenotypes. Our findings demonstrate broad immune perturbations spanning both innate and adaptive leukocytes that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation. One Sentence Summary Broad immune perturbations in severe COVID-19
has issue date	2020-05-18(xsd:dateTime)
bibo:doi	10.1101/2020.05.18.101717
bibo:pmid	32511394
has license	biorxiv
sha1sum (hex)	2ccf9cee81ab6b25002c6dfc392ea88276ce8225
schema:url	https://doi.org/10.1101/2020.05.18.101717
resource representing a document's title	Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection
has PubMed identifier	32511394
schema:publication	bioRxiv
resource representing a document's body	covid:2ccf9cee81ab6b25002c6dfc392ea88276ce8225#body_text
is schema:about of	named entity 'perturbations' named entity 'immune' named entity 'recovered' named entity 'immune' named entity 'COVID-19' named entity 'perturbations' named entity 'Title' named entity 'hyperinflammation' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'Immunologic' named entity 'clone' named entity 'IgM' named entity 'HCMV' named entity 'CD8+ T cells' named entity 'SARS-CoV-2' named entity 'logistic regression' named entity 'COVID-19' named entity 'immunopathology' named entity 'granulocytes' named entity 'COVID' named entity 'inflammatory' named entity 'IgG' named entity 'COVID' named entity 'plasmablast' named entity 'COVID' named entity 'CD8+ T cell' named entity 'multiple comparison' named entity 'NK cells' named entity 'COVID' named entity 'monocytes' named entity 'Thromboembolic complications' named entity 'D20' named entity 'heterogeneity' named entity 'COVID-19' named entity 'staining' named entity 'plasmablasts' named entity 'S4C' named entity 'p<0.05' named entity 'CD45+' named entity 'statistical significance' named entity 'SARS-CoV-2' named entity 'neutrophil' named entity 'lymphocyte' named entity 'asthma' named entity 'COVID' named entity 'moderate group' named entity 'immune responses' named entity 'CD8+ T cells' named entity 'SARS-CoV-2' named entity 'single case' named entity 'metabolic disorders'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software