About: Molecular detection of respiratory pathogens and typing of human rhinovirus of adults hospitalized for exacerbation of asthma and chronic obstructive pulmonary disease

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About: Molecular detection of respiratory pathogens and typing of human rhinovirus of adults hospitalized for exacerbation of asthma and chronic obstructive pulmonary disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular detection of respiratory pathogens and typing of human rhinovirus of adults hospitalized for exacerbation of asthma and chronic obstructive pulmonary disease
Creator	Chan, Ka-Pang Ip, April Kwok, Angela Ng, So-Shan Chan, Renee On, Chan Chun-Li Ngai, Jenny Kay-Sheung Chan, Paul Shu-Cheong Hui, David Wai-San Ko, Fanny
Source	Medline; PMC
abstract	BACKGROUND: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and asthma are associated with a variety of precipitating factors including infection. This study assessed the infective viral etiologies by real-time multiplex polymerase chain reaction of patients hospitalized with AECOPD and asthma exacerbations. In addition, infective etiologies were assessed for association with the clinical outcome of the patients. METHODS: Adults admitted with AECOPD and asthma exacerbations between August 2016 and July 2017 were recruited. Nasopharyngeal aspirate (NPA) samples were obtained from the patients within 1–2 days of admission and subjected to pathogen detection and human rhinovirus (HRV) typing. RESULTS: Altogether 402 patients with AECOPD, 80 stable COPD, 100 asthma exacerbation and 21 stable asthma subjects were recruited. Among those admitted for AECOPD and asthma exacerbations, 141(35.1%) and 45(45.0%) respectively had pathogens identified in the NPA specimens. The commonest virus identified was influenza A followed by HRV. HRV typing identified HRV-A and HRV-C as the more common HRV with a wide variety of genotypes. Identification of pathogens in NPA or HRV typing otherwise did not affect clinical outcomes including the hospital length of stay, readmission rates and mortality except that identification of pathogens in asthma exacerbation was associated with a lower rate of readmissions at 30 and 60 days. CONCLUSIONS: Many respiratory viruses were associated with AECOPD and asthma exacerbation. HRV-A and HRV-C were the more common HRV associated with exacerbations. Identification of pathogens in NPA was associated with less readmissions for asthma patients at 30 and 60 days. TRIAL REGISTRATION: ClinicalTrials.gov NCT02866357. SUPPLEMENTARY INFORMATION: Supplementary information accompanies this paper at10.1186/s12931-019-1181-0.
has issue date	2019-09-13(xsd:dateTime)
bibo:doi	10.1186/s12931-019-1181-0
bibo:pmid	31519188
has license	cc-by
sha1sum (hex)	26d8317a46bcbe3ec8ff5aa98de2a848fbd358ca
schema:url	https://doi.org/10.1186/s12931-019-1181-0
resource representing a document's title	Molecular detection of respiratory pathogens and typing of human rhinovirus of adults hospitalized for exacerbation of asthma and chronic obstructive pulmonary disease
has PubMed Central identifier	PMC6743175
has PubMed identifier	31519188
schema:publication	Respir Res
resource representing a document's body	covid:26d8317a46bcbe3ec8ff5aa98de2a848fbd358ca#body_text
is schema:about of	named entity 'MOLECULAR' named entity 'patients' named entity 'asthma' named entity 'hospitalized' named entity 'TYPING' named entity 'CHRONIC OBSTRUCTIVE PULMONARY DISEASE' named entity 'ACUTE EXACERBATIONS' named entity 'OUTCOME' named entity 'INCLUDING' named entity 'MULTIPLEX POLYMERASE CHAIN REACTION' named entity 'ETIOLOGIES' named entity 'VARIETY' named entity 'RESPIRATORY PATHOGENS' named entity 'ASTHMA' named entity 'PRECIPITATING FACTORS' named entity 'ASSOCIATION' named entity 'CLINICAL' named entity 'REALTIME' named entity 'HOSPITALIZED' covid:arg/26d8317a46bcbe3ec8ff5aa98de2a848fbd358ca named entity 'ADULTS' named entity 'PATIENTS' named entity 'HOSPITALIZED' named entity 'EXACERBATION OF ASTHMA' named entity 'ADDITION' named entity 'ASTHMA EXACERBATIONS' named entity 'ASSESSED' named entity 'INFECTION' named entity 'BACKGROUND' named entity 'STUDY' named entity 'HUMAN RHINOVIRUS' named entity 'VIRAL' named entity 'ASSOCIATED WITH' named entity 'CHRONIC OBSTRUCTIVE PULMONARY DISEASE' named entity 'DETECTION' named entity 'infective' named entity 'etiologies' named entity 'asthma' named entity 'polymerase chain reaction' named entity 'infection' named entity 'human rhinovirus' named entity 'asthma exacerbations' named entity 'asthma exacerbations' named entity 'asthma' named entity 'American Thoracic Society' named entity 'Hong Kong' named entity 'asthma exacerbations' named entity 'paediatric' named entity 'AECOPD' named entity 'asthma exacerbation' named entity 'respiratory viral infections' named entity 'HRV' named entity 'influenza' named entity 'Clinical outcomes' named entity 'OC43' named entity 'asthma' named entity 'HRV' named entity 'FEV' named entity 'nasopharyngeal aspirate' named entity 'human metapneumovirus' named entity 'influenza' named entity 'AECOPD' named entity 'HRV' named entity 'asthma' named entity 'asthma exacerbation' named entity 'seasonal variation' named entity 'melting curve analysis' named entity 'COPD' named entity 'COPD' named entity 'pathogens' named entity 'Clinical Research Ethics' named entity 'AECOPD'

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