About: Exploratory cohort study to determine if dry cow vaccination with a Salmonella Newport bacterin can protect dairy calves against oral Salmonella challenge

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About: Exploratory cohort study to determine if dry cow vaccination with a Salmonella Newport bacterin can protect dairy calves against oral Salmonella challenge Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Exploratory cohort study to determine if dry cow vaccination with a Salmonella Newport bacterin can protect dairy calves against oral Salmonella challenge
Creator	Smith, Geof Foster, Derek Jacob, Megan Stowe, Devorah
Source	PMC
abstract	BACKGROUND: Salmonellosis is a major cause of morbidity and mortality in neonatal calves, often occurring before preventative vaccines can be administered. HYPOTHESIS/OBJECTIVE: To evaluate the protective effect on calves of colostrum from cows vaccinated with a commercially available Salmonella Newport bacterin against a Salmonella Typhimurium challenge. ANIMALS: Twenty Holstein bull calves from a university dairy farm. METHODS: Nonrandomized placebo‐controlled trial in which colostrum was harvested from 30 cows that received 2 doses of either Salmonella bacterin or saline before calving. Colostrum collected from each group was pooled and fed to 2 groups of 10 calves at birth. At approximately 2 weeks of age, calves were challenged with Salmonella Typhimurium. Clinical, hematologic, microbiological, and postmortem findings were compared between the 2 groups. RESULTS: No differences in mortality, clinical findings, hematology results, blood and fecal cultures, or necropsy findings between the 2 groups were observed. Vaccinated cows had higher colostral titers, and calves fed this colostrum had higher serum titers (mean difference, 0.429; mean [SE], 0.852 [0.02] for vaccinated versus 0.423 [0.02] for control calves). CONCLUSIONS AND CLINICAL IMPORTANCE: Transfer of colostral immunoglobulins from Salmonella enterica serotype Newport bacterin to neonatal calves was not sufficient to decrease mortality, clinical signs, sepsis, intestinal damage, or fecal shedding when exposed to a highly pathogenic Salmonella isolate. A large‐scale randomized controlled clinical trial is needed to evaluate the efficacy of this bacterin when administered in the dry period for prevention of salmonellosis in neonatal calves.
has issue date	2019-05-27(xsd:dateTime)
bibo:doi	10.1111/jvim.15529
bibo:pmid	31134697
has license	cc-by-nc
sha1sum (hex)	24bc853dce27cbe938ca42aefdaa4e788df30481
schema:url	https://doi.org/10.1111/jvim.15529
resource representing a document's title	Exploratory cohort study to determine if dry cow vaccination with a Salmonella Newport bacterin can protect dairy calves against oral Salmonella challenge
has PubMed Central identifier	PMC6639490
has PubMed identifier	31134697
schema:publication	J Vet Intern Med
resource representing a document's body	covid:24bc853dce27cbe938ca42aefdaa4e788df30481#body_text
is schema:about of	named entity 'DAIRY CALVES' named entity 'IS A' named entity 'MORBIDITY AND MORTALITY' named entity 'Background' named entity 'preventative' named entity 'Salmonella' named entity 'Exploratory' named entity 'SALMONELLA NEWPORT' named entity 'A MAJOR' named entity 'BACKGROUND' named entity 'CAUSE' named entity 'DETERMINE' named entity 'COHORT STUDY' named entity 'VACCINATION' named entity 'BACTERIN' named entity 'DRY' named entity 'COW' named entity 'ORAL' named entity 'NEONATAL' named entity 'VACCINES' named entity 'ADMINISTERED' named entity 'SALMONELLA' named entity 'CHALLENGE' named entity 'PREVENTATIVE' named entity 'SALMONELLOSIS' named entity 'CALVES' covid:arg/24bc853dce27cbe938ca42aefdaa4e788df30481 named entity 'mortality' named entity 'vaccines' named entity 'Salmonella' named entity 'severe depression' named entity 'formalin-fixed' named entity 'Salmonella' named entity 'VAX' named entity 'VAX' named entity 'VAX' named entity 'light microscopy' named entity 'colostrum' named entity '10.6' named entity 'ileal' named entity 'Salmonella infections' named entity 'colostrum' named entity 'CTL' named entity 'humoral immunity' named entity 'subunit vaccine' named entity 'electrical resistance' named entity 'magnesium hydroxide' named entity 'cell-mediated immunity' named entity 'cell-mediated immunity' named entity 'morbidity' named entity '36 hours' named entity 'Blood culture' named entity 'milk replacer' named entity 'colostrum' named entity 'long-term' named entity 'Diarrhea' named entity 'porin' named entity 'epithelial' named entity 'inoculated' named entity 'vaccination' named entity 'binary variable' named entity 'depression' named entity 'colostrum' named entity 'sample size' named entity 'white blood cell differential' named entity 'band neutrophil' named entity 'antibody' named entity 'total mixed ration' named entity 'lactation' named entity 'colony-forming units' named entity 'laboratory animal' named entity 'leukocytes' named entity 'Packed cell volume' named entity 'chlorinated water' named entity 'infection' named entity 'CTL' named entity 'chlorination' named entity 'subunit vaccine'

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